Congrats to #ListerFellow @jamesnathanlab.bsky.social and team on this tremendous paper in Science Advances exploring iron flux and metabolism. "Potentially explaining how some tumors evade antitumoral immunity."

Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.

"The Lister... spans an incredible breadth of science, giving access to world-leading experts in fields far from my own." @jamesnathanlab.bsky.social

James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize

👉 lister-institute.org.uk/curiosity-at...

Thanks Pari!

🧬 New in @natchembio.nature.com :

Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe

@hudsonwilco.bsky.social @jamesnathanlab.bsky.social

Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

www.nature.com/articles/s41...

🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social

Thanks to all members of the Nathan lab and our wonderful collaborators. #hypoxia #metabolism.

Third - our work examining synthetic lethality with VHL in renal cancer, uncovering a role for CBFB as a suppressor of Type I interferon signalling. www.biorxiv.org/content/10.1...

Second - our work with Randall Johnson's group uncovering a novel role for how ABHD11 controls #lipoylation by acting as a lipoyl deglutarylating enzyme to regulate the TCA cycle. www.biorxiv.org/content/10.1...

Having just joined bsky, thought it would be good to share our latest review and a couple of recent preprints from the group. First our review on the roles of deubiquitinating enzymes in hypoxia responses. portlandpress.com/biochemsoctr...

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.