Lightnews — Scholar-powered news

Reposted by Jan Hartmann, M.D.

NEJM.org @nejm.org · 7d

Monoclonal gammopathy of undetermined significance is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. Diagnosis warrants follow-up, but treatment is not required unless progression is confirmed. Learn more: nej.md/473uOsj

An illustrated diagram of the pathogenesis and progression of monoclonal gammopathy of undetermined significance (MGUS).

4 8

Reposted by Jan Hartmann, M.D.

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 24d

“For physician–scientists conducting early clinical trials, the results could best be described as miraculous.” 🧪
2025 #LaskerAward winners M. Welsh, J. González, & P. Negulescu developed life-saving #cysticfibrosis treatments. @nejm.org
#Lasker2025

Transformative Research in Cystic Fibrosis | NEJM

Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

www.nejm.org

8 15

Reposted by Jan Hartmann, M.D.

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 24d

“The insights of Görlich, McKnight, and their colleagues are being harnessed in medical research.” 🧪
Read how low-complexity domains of proteins impact human health in @nejm.org
#LaskerAward #Lasker2025 @mpi-nat.bsky.social
#phaseseparation #biophysics
www.nejm.org/doi/full/10....

Surprisingly Complex Assemblies from Low-Complexity Domains | NEJM

Drs. Görlich and McKnight have won the 2025 Albert Lasker Award for Basic Medical Research for showing that low-complexity domains of proteins lack structure on their own and yet can form assembled .....

www.nejm.org

3 5

Jan Hartmann, M.D. @janhartmannmd.bsky.social · 26d

www.nature.com/articles/s41...

Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis - Cell Research

Cell Research - Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis

www.nature.com

1

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Sep 8

"Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants"

ascpt.onlinelibrary.wiley.com/doi/abs/10.1...

Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel‐Treated Participants

Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial ...

ascpt.onlinelibrary.wiley.com

1 2

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Sep 8

"Long-Term Outcomes of the DanGer Shock Trial"

www.nejm.org/doi/full/10....

Long-Term Outcomes of the DanGer Shock Trial | NEJM

In patients with STEMI with cardiogenic shock, early mechanical support with a microaxial pump reduced the risk of death at 180 days, with the survival benefit persisting up to 10 years despite dev...

www.nejm.org

1

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Sep 8

"Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation"

jamanetwork.com/journals/jam...

Discontinuation of Anticoagulant Therapy After Catheter Ablation for Atrial Fibrillation

This randomized clinical trial compares discontinuing vs continuing oral anticoagulant therapy in patients without documented atrial arrhythmia recurrence after catheter ablation for atrial fibrillati...

jamanetwork.com

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Sep 8

"Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis" www.thelancet.com/journals/lan...

Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis

These findings add to the evidence that clopidogrel monotherapy is superior to aspirin monotherapy for MACCE prevention with no increase in the risk of bleeding, and support the preferential use of cl...

www.thelancet.com

1

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Sep 8

Good thing I don't drink coffee...
news.cuanschutz.edu/news-stories...

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

news.cuanschutz.edu

Reposted by Jan Hartmann, M.D.

NEJM.org @nejm.org · Sep 3

In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment. Full study results: nej.md/4pkaYAq

#MedSky #CardioSky

Figures showing the detection and function of anti–PF4–heparin antibodies from patients with heparin-induced thrombocytopenia.

5 15

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Aug 30

Rainbow over Sandy Bay – Rockport, MA 🌈

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Aug 6

Sex differences in dual antiplatelet therapy de-escalation strategies after percutaneous coronary intervention: a network meta-analysis url: academic.oup.com/eurheartj/ar...

Sex differences in dual antiplatelet therapy de-escalation strategies after percutaneous coronary intervention: a network meta-analysis

AbstractBackground and Aims. Dual antiplatelet therapy (DAPT) de-escalation strategies improve outcomes after percutaneous coronary intervention (PCI) comp

academic.oup.com

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Aug 1

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | New England Journal of Medicine www.nejm.org/doi/full/10....

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery | NEJM

Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilu...

www.nejm.org

Reposted by Jan Hartmann, M.D.

NEJM.org @nejm.org · Jul 13

In the BATURA phase 3b trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results and Research Summary: nej.md/43uVpwK

The New England Journal of Medicine
As-Needed Albuterol–Budesonide in Mild Asthma
A Research Summary based on LaForce C et al. | 10.1056/NEJMoa2504544 | Published on May 19, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

2 3 12

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jul 11

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | New England Journal of Medicine www.nejm.org/doi/abs/10.1...

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | NEJM

Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence t...

www.nejm.org

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jun 22

Last night at #ISTH2025, we honored a gentle giant—Dr. Hau Kwaan, Professor Emeritus at ⁦‪⁦‬⁩Northwestern. A true #Fibrinolysis pioneer with 400+ articles since the 1950s—still contributing posters in his 90s. Thanks, Mark Walsh, for a moving laudatio.
@isth.org
www.linkedin.com/posts/janhar...

Later last night at #ISTH2025, we had the privilege of honoring a gentle giant of the field—Dr. | Jan Hartmann, M.D.

Later last night at #ISTH2025, we had the privilege of honoring a gentle giant of the field—Dr. Hau Kwaan, MD, PhD, FRCP, FACP, Professor Emeritus at Northwestern University - The Feinberg School of M...

www.linkedin.com

1 8

Reposted by Jan Hartmann, M.D.

Michael Mina MD,PhD @michaelmina.bsky.social · Jun 11

It’s Code Red for Vaccines

The number of changes to vaccine policy is dizzying & RFK Jr is just getting started!

Dissolving the group of experts that drive policy is declaring war on “what was”

I write in @nytimes.com about what is and is not working

www.nytimes.com/2025/06/11/o...

Opinion | It’s Code Red for Vaccines in America (Gift Article)

How to make sense of all the vaccine policy changes.

www.nytimes.com

3 26 49

Reposted by Jan Hartmann, M.D.

Nature @nature.com · Jun 10

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

280 2K 9.2K

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jun 9

bbc.com/news/article...

NHS calls for 200,000 new blood donors as supplies run low

The health service issued an "amber alert" last year and stocks remain low ever since.

bbc.com

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jun 9

2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP url:https://academic.oup.com/ejcts/article/67/5/ezae352/7815985

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jun 8

Public radio in Boston… 📻 ⁦‪ ⁦‬⁩ #BumpaSticka @npr.org @wbur.org

1

Jan Hartmann, M.D. @janhartmannmd.bsky.social · Jun 5

🇺🇸 🇩🇪 www.espn.com/nhl/story/_/...

Bruins turn to ex-forward Sturm as head coach

The Boston Bruins hired Marco Sturm as coach on Thursday to help the Original Six franchise get back to the playoffs after missing them for the first time since 2016.

www.espn.com

Jan Hartmann, M.D. @janhartmannmd.bsky.social · May 29

jamanetwork.com/journals/jam...

Platelet Transfusion International Clinical Practice Guidelines

This Special Communication discusses the updated Association for the Advancement of Blood and Biotherapies and the International Collaboration for Transfusion Medicine Guidelines international clinica...

jamanetwork.com

1

Jan Hartmann, M.D. @janhartmannmd.bsky.social · May 8

If you read one thing today, make it this: an epochal speech by the German President on the occasion of the 80th anniversary of Germany's capitulation at the end of WW2.

www.bundespraesident.de/SharedDocs/R...

“We are all children of 8 May”

On the 80th anniversary of the end of the Second World War, Federal President Steinmeier has called for remembrance not to become routine. “Our history is a precious treasure trove of experience. Let us trust in our experience,” he said at a commemoration ceremony in the Bundestag.

www.bundespraesident.de

Reposted by Jan Hartmann, M.D.

NEJM.org @nejm.org · May 2

For a woman with device-detected atrial fibrillation, would you initiate anticoagulant therapy or recommend continuation of antiplatelet therapy? Read the case vignette and essays on both treatment options and cast your vote: nej.md/4lQzxTA

#MedSky #CardioSky #Afib

CLINICAL DECISIONS
Anticoagulation or Antiplatelet Therapy for Device-Detected Atrial Fibrillation

An illustration of a smartwatch monitoring ECG and two bottles, one containing an anticoagulant, and the other containing aspirin

3 6 9