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Reposted by Jarcy Zee

International Society of Glomerular Disease @isgd.bsky.social · 6d

PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social

PARASOL Project Expands Focus to APOL1, Membranous Nephropathy

PARASOL Project expands to focus on APOL1 kidney disease and primary membranous nephropathy, aiming to improve clinical trial endpoints for these conditions.

eu1.hubs.ly

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Jarcy Zee @jarcyzphd.bsky.social · 7d

🚨NEW paper alert🚨 co-led by Fan Fan, Jane (Qian) Liu (from the zeelab.org), and an interdisciplinary, multi-institutional team using computational image analysis and machine learning methods to identify novel tubular features associated with clinical outcomes above and beyond known risk factors👇

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Jarcy Zee @jarcyzphd.bsky.social · Sep 8

See our paper on the unfortunately popular "time-averaged" method in nephrology literature: doi.org/10.2215/CJN....

Methods for Assessing Longitudinal Biomarkers of... : Clinical Journal of the American Society of Nephrology

assessed accuracy of methods using computer simulations and compared biomarker association estimates in the NEPhrotic syndrome sTUdy NEtwork (NEPTUNE), a prospective cohort study of patients with glom...

doi.org

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Jarcy Zee @jarcyzphd.bsky.social · Sep 8

"Kidney survival times were calculated from baseline...Change in proteinuria was calculated from baseline value to either lowest proteinuria value or time-averaged proteinuria in the 6–12 and 6–24 months periods after baseline." Ie uses future to predict future which can greatly exaggerate effects 😩

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Jarcy Zee @jarcyzphd.bsky.social · Jul 23

Why not?🤔 Seems like an efficient use of resources to answer multiple questions. I don't see a problem

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Jarcy Zee @jarcyzphd.bsky.social · Jun 30

Want to become a pro in statistical analysis? Know someone who might be interested in Biostatistics graduate programs? 📈🧮🖥️🎓 Share and come to the @upenn.edu @dbei-upenn.bsky.social Open House on 9/12/25. Registration is *free* and you could even win some swag! www.med.upenn.edu/ggeb/biostat...

Flyer from the University of Pennsylvania Perelman School of Medicine Graduate Group in Epidemiology and Biostatistics advertising a Virtual Open House on Graduate Programs in Biostatistics. Date: September 12, 2025, Time: 11am-3pm ET. Learn about MD and PhD Biostatistics programs, hear research talks by faculty and students, chat with current students, ask questions, and win prizes! Find more information at https://www.med.upenn.edu/ggeb/biostatisticsopenhouse2025.html and register for free.

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Jarcy Zee @jarcyzphd.bsky.social · Jun 24

❤️

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Jarcy Zee @jarcyzphd.bsky.social · Jun 23

Morning or mid to late afternoon timing rather than mid-day (lunch time/nap time) 😅

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Jarcy Zee @jarcyzphd.bsky.social · Jun 23

Great you feel supported and kids enjoy participating! And perhaps encouraging for some parents on the fence. For others who don't feel that same support in their cities, with kids afraid of crowds or loud noises, or those just too exhausted, there has to be space for *guilt-free* virtual activism

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Jarcy Zee @jarcyzphd.bsky.social · Jun 11

Hi! 👋 I'm Jarcy Zee, only a pretend adult and pediatric nephrologist, but actually a biostatistician doing lots of GN and other kidney research. Hoping I'm still allowed to hang 😅. First time on #NephJC!

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Reposted by Jarcy Zee

Stand Up for Science! @standupforscience.bsky.social · Jun 9

“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.”

www.science.org/content/arti...

#StandUpForScience
#BethesdaDeclaration

NIH staff and biomedical community sound alarm about agency politicization, funding slowdown

In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes

www.science.org

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Jarcy Zee @jarcyzphd.bsky.social · May 29

"Robustness of results to assumptions" 😅

(but also the standard error matters too!!)

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Reposted by Jarcy Zee

Jeremy Berg @jeremymberg.bsky.social · May 26

Proud to sign on this this open letter.

Join me....

www.standupforscience.net/open-letter-...

Open Letter in Support of Science — STAND UP FOR SCIENCE

www.standupforscience.net

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Jarcy Zee @jarcyzphd.bsky.social · May 24

A 10 mg/kg/day increase in cr generation could lead to a 36 ml/min/1.73m2 decrease in eGFR in a 35yo male or 18 ml/min/1.73m2 decrease in a 8yo female with NO actual change in kidney function! 😳

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Jarcy Zee @jarcyzphd.bsky.social · May 24

"Besides age, sex, and weight, important factors that can impact creatinine generation include urine protein in children and kidney function, disease diagnosis, steroid use, and nonsteroid immunosuppressant use in adults."

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Jarcy Zee @jarcyzphd.bsky.social · May 24

🚨New paper alert🚨 from the zeelab.org. @dbei-upenn.bsky.social PhD biostats candidate Shalini Ramachandra found high variability in creatinine generation among GN pts over time, yet we usually assume it's stable to calculate sCr-based eGFR 😩. Check it out 👇 www.sciencedirect.com/science/arti...

Variations in Creatinine Generation Among Patients With Glomerular Disease: Evidence From the NEPTUNE and CureGN Studies

Estimation of glomerular filtration rate (GFR) assumes that creatinine generation (crG) is relatively stable. This study identified factors associated…

www.sciencedirect.com

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Jarcy Zee @jarcyzphd.bsky.social · May 20

Yes exactly, the latter was my concern. Didn't see the part about autism but would agree 🙄

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Jarcy Zee @jarcyzphd.bsky.social · May 19

Can you clarify? When I first saw the CNN article and started looking into Healthy Babies, Bright Futures, I was skeptical (eg, the report is not written how one would expect scientific research to be written), but could not find much info about them

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Jarcy Zee @jarcyzphd.bsky.social · May 14

A call to action for researchers to advocate not only for funding but to put pressure on universities, professional societies, and government representatives to protect academic freedom, international scholars, and science as a whole: rdcu.be/elOdv

US researchers must stand up to protect freedoms, not just funding | Nature

Curtailment of freedoms and disregard for the rule of law in the United States is destroying the ability of science to serve the nation’s, and the world’s, interests. Researchers can take action. Curtailment of freedoms and disregard for the rule of law in the United States is destroying the ability of science to serve the nation’s, and the world’s, interests. Researchers can take action.

rdcu.be

Jarcy Zee @jarcyzphd.bsky.social · May 12

@super-jrub.bsky.social

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Jarcy Zee @jarcyzphd.bsky.social · May 12

Came across this list of free datasets: hbiostat.org/data/#vanderbilt-biostatustics-datasets -- great resource for teaching (and maybe research too)!

Datasets

hbiostat.org

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Jarcy Zee @jarcyzphd.bsky.social · May 1

Some movement toward NIH support at the congressional hearing on biomedical research today: www.politico.com/live-updates...

Collins says Trump’s research cuts ‘must be reversed’

The Maine Republican could use her chair at Senate Appropriations to push back.

www.politico.com

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Jarcy Zee @jarcyzphd.bsky.social · Apr 25

Great idea! Reposting with Alt Text.

This order states Schedule Policy/Career employees:

"are required to faithfully implement administration policies to the best of their ability, consistent with their constitutional oath and the vesting of executive authority solely in the President. Failure to do so is grounds for dismissal."

It also states that:

"the President will make the final decision about which positions go into Schedule Policy/Career."

And "guidance about positions agencies should consider in their Schedule Policy/Career positions" includes those with:

"Substantive participation and discretionary authority in agency grantmaking, such as the substantive exercise of discretion in the drafting of funding opportunity announcements, evaluation of grant applications, or recommending or selecting grant recipients. Grantmaking is an important form of policymaking, so employees with a substantive discretionary role in how federal funding gets allocated may occupy policymaking positions."

This indicates that all involved in all grantmaking are considered policymaking positions and that the President can dictate whether those individuals' actions are aligned with their policies -- no matter who the President is or their party affiliation. Those involved in grantmaking should be nonpartisan career civil servants with appropriate expertise and experience to write funding announcements, evaluate grant applications, and recommend grant funding to achieve the missions of their agencies. They should not have to live in fear that their positions would be at risk if their expert-driven, rigorous decision-making is not consistent with one person's opinions. Adoption of this Proposed Rule will have dire consequences on our country's ability to conduct the best research, educate the best trainees, build the best infrastructure, and provide the best services.

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Jarcy Zee @jarcyzphd.bsky.social · Apr 24

Borrowed from @sciencelizard.bsky.social so figured I'd also share for others wanting ideas. Here's mine.

Several paragraphs of text quoting from the Office of Personnel Management's Proposed Rule on Improving Performance, Accountability, and Responsiveness in the Civil Service and expressing criticisms specifically about the dangers of considering all involved with grantmaking as policymakers beholden to the President.

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Jarcy Zee @jarcyzphd.bsky.social · Apr 24

Hey I know these people! Check out this paper👇

American Journal of Kidney Diseases @ajkd.bsky.social · Apr 23

Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study

bit.ly/3DHbXai (FREE)

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