American Journal of Kidney Diseases
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American Journal of Kidney Diseases
@ajkd.bsky.social
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AJKD, official journal of @kidney.org, is the leading source of information devoted to clinical nephrology research and practice. AJKD.org | AJKDblog.org | Organizer of #NephMadness @nephmadness.bsky.social
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American Journal of Kidney Diseases @ajkd.bsky.social · 26d
The January 2026 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4q2QuMj
ajkd.bsky.social
Health-Related Quality of Life After Living Kidney Donation: A Systematic Review and Meta-Analysis

bit.ly/47SMtCh #OpenAccess
January 31, 2026 at 11:00 PM
ajkd.bsky.social
NEW on #AJKDBlog: AJKD invites applications for its Editorial Internship Program, which will provide editorial experience to early career researchers interested in education, teaching, or medical editing/writing.

bit.ly/3Z64pFG
January 31, 2026 at 5:01 PM
ajkd.bsky.social
A 24-year-old female with history of epilepsy, depression, and CKD presented to the ED for suicidal ideation and was found to have a creatinine of 6.24 mg/dL

How can skin lesions guide the differential diagnosis for the CKD etiology in this patient?

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Raised bumpy skin.
January 31, 2026 at 11:00 AM
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In A Few Words essay by Christina Fang, MD: Physician as Patient

bit.ly/3Xm1I1U (FREE)
January 30, 2026 at 11:00 PM
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Navigating Anemia Therapy in CKD: The Role of Hypoxia-Inducible Factor Activators

bit.ly/3NOciNx (OPEN ACCESS)
Reversible HIF activation by pharmacological HIF-prolyl-hydroxylase inhibition. Schematic overview of hypoxia-inducible factor (HIF) regulation. The oxygen-sensitive HIF-α subunit is continuously synthesized and rapidly degraded under normoxic conditions. Proteasomal degradation of HIF-α is initiated by prolyl hydroxylase domain (PHD) dioxygenases and mediated by the von Hippel-Lindau (VHL)-E3-ubiquitin ligase complex. PHD dioxygenases, PHD1, PHD2 and PHD3 utilize molecular oxygen and 2-oxoglutarate (2OG) as substrates to hydroxylate the oxygen-sensitive HIF-α subunit at specific proline residues (Pro), with PHD2 being the main regulator of HIF activity in most cells.
January 30, 2026 at 5:03 PM
ajkd.bsky.social
Urine Oxalate Excretion and CKD Stage in Patients With Primary Hyperoxaluria Type 1

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Primary hyperoxaluria type 1 (PH1) patient trajectory plots of estimated glomerular filtration rate (eGFR) versus urinary oxalate (UOx). All available laboratory measures for each PH1 patient are depicted as separate lines, with a bold solid line overlaid for the estimated average UOx across eGFR levels modeled via a piecewise regression linear mixed modeling approach and a spline knot of eGFR = 25 mL/min/1.73 m2. Dotted lines indicate the 95% confidence intervals of the fixed effects. To increase readability, a random sample of one-third of the cohort has within-patient trajectories represented by nontransparent lines, and the remaining two-thirds of the cohort has within-patient trajectories represented by semi-transparent lines.
January 30, 2026 at 11:00 AM
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In this Brief Guide, Insa Schmidt and Eugene Rhee summarize key principles and provide practical insights into the interpretation of metabolomics and proteomics studies, with a focus on blood-based analyses in human cohorts.

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General workflow and considerations for interpreting metabolomics and proteomics studies in kidney disease research.
January 29, 2026 at 11:02 PM
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Collagenofibrotic Glomerulopathy Associated With Homozygous STAB2 and Heterozygous STAB1 Variants: A Case Report

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(A) Light microscopic observation with periodic acid–Schiff staining revealed glomeruli with thickened capillary walls and subendothelial accumulation of pale, homogeneous material, which was also present throughout the mesangial regions. (B) Periodic acid-methenamine-silver staining highlighted a double-contour appearance. (C) Congo red staining for amyloid was negative. (D) Immunohistochemical staining demonstrated positivity for type III collagen in the mesangium and subendothelial space. Scale bar, 50 μm.
January 29, 2026 at 5:01 PM
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Feb 2026 issue featuring #NephMadness on the cover: bit.ly/4t6uTof

Highlights:
- KDOQI Commentary on Management of Nephrotic Syndrome in Children
- Chronic Pain in Adults on Hemodialysis
- Access to Kidney Transplant in Severe Obesity
- Exercise & Kidney Health
Current Issue Table of Contents: American Journal of Kidney Diseases
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January 29, 2026 at 2:02 PM
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Association of Fatty Liver Disease and the Risk of Nephrolithiasis: Findings From Two Prospective Cohort Studies

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January 29, 2026 at 11:02 AM
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NEW on #AJKDBlog: AJKD invites applications for its Editorial Internship Program, which will provide editorial experience to early career researchers interested in education, teaching, or medical editing/writing.

bit.ly/3Z64pFG
January 29, 2026 at 11:00 AM
ajkd.bsky.social
IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency

bit.ly/3Le1OFK
January 28, 2026 at 11:00 PM
ajkd.bsky.social
Associations of Skeletal Muscle Mass and Body Mass Index With Clinical Outcomes in Autosomal-Dominant Polycystic Kidney Disease: An Observational Study

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January 28, 2026 at 5:01 PM
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Impact of Smartphone-Enabled Home Urinary Albumin-to-Creatinine Ratio Testing on Albuminuria Screening and Management

bit.ly/4pMQekv (OPEN ACCESS)

@alexchangmd.bsky.social
January 28, 2026 at 11:06 AM
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Pharmaceutical Practice Considerations Regarding Adoption of the Race-Free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 Equations

bit.ly/4rtzHTK (OPEN ACCESS)
Time line for the development of different eGFR equations(adapted from Gansevoort et al, 2023). ∗Refers to eGFRcr formulae excepting where cystatin is shown. eGFRcr overestimates and underestimates are median values versus mGFR. Abbreviations: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; CKD-EPI 2009 NB, CKD-EPI 2009 equation without race coefficient; eGFR, estimated glomerular filtration rate; eGFRcr, estimated glomerular filtration rate creatinine-based formulae; EKFC, European Kidney Function Consortium; MDRD-4, 4-variable Modification of Diet in Renal Disease equation; mGFR, measured glomerular filtration rate.
January 28, 2026 at 11:00 AM
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Hematologic Considerations in Kidney Transplantation: Core Curriculum 2025

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Typical patterns of drug-induced neutropenia.
January 27, 2026 at 11:02 PM
Reposted by American Journal of Kidney Diseases
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Enjoyed working on this manuscript with several amazing pharmacist leaders! As nephrology continues its renaissance, pharmacists are key members of the care team. Pharmacist integration continues to evolve with many unique models and collaboration.
ajkd.bsky.social American Journal of Kidney Diseases @ajkd.bsky.social · 11d
Optimizing Comprehensive Medication Management in CKD: An Opportunity to Integrate Pharmacists in the Kidney Care Team

bit.ly/3NrkpiZ
January 27, 2026 at 5:22 PM
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Free to Be in Peritoneal Dialysis: Without Kt/V?

bit.ly/49Wyf4t (OPEN ACCESS)
Limitations of Kt/V in PD There are several limitations to use of Kt/V in PD including: (1) urea as an inappropriate surrogate for clearance of all uremic toxins, (2) physiologic differences between HD and PD, (3) no difference in mortality based on Kt/V targets, (4) peritoneal Kt/V is not equivale to residual kidney Kt/V, (5) inaccuracies in measurement of “V”, (6) increased time and resources for health care teams.
January 27, 2026 at 5:03 PM
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What's New in Membranous Nephropathy and How to Incorporate New Antigen Discoveries into Clinical Practice?

REVIEW by Ladan Zand, Fernando C. Fervenza, and Sanjeev Sethi

bit.ly/3J9d1qO
January 27, 2026 at 11:00 AM
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KDOQI US Commentary on the @kdigo.org 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children

bit.ly/KDOQI25NS (FREE)

@kidney.org @nkf-professionals.bsky.social #KDOQI
January 27, 2026 at 10:02 AM
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#NephMadness 2026: Blue Ribbon Panel

bit.ly/45sGUdu

@therealdrdub.bsky.social @roy-chaudhury.bsky.social @maximalchange.bsky.social
January 26, 2026 at 11:00 PM
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Expanding Our Understanding of Genetic Variations That Impact Post-Transplant Outcomes

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(A) Decreased donor kidney transplant rates among adult waitlist candidates by race and ethnicity. Adapted from the 2023 SRTR annual data report figure KI 16. (B). Percentage of African American deceased donor kidneys that are transplanted into African American recipients.
January 26, 2026 at 5:02 PM
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Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation

bit.ly/47wHN6h #OpenAccess
January 26, 2026 at 11:02 AM
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Mini-Review:

Metabolic Bariatric Surgery in Kidney Transplant Candidates

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Suggested weight loss treatment pathways to achieve eligibility for kidney transplantation for patients with advanced kidney disease. aGLP1/GIP RA should be considered in all kidney transplant candidates as either a bridge to MBS, an alternative to MBS, or to enhance the weight loss effect of MBS. bNo rigid upper age limit for bariatric surgery. Frailty, not chronological age, should guide decision making. Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; GIP, glucose-dependent insulinotropic polypeptide; GLP1 RA, glucagon-like peptide-1 receptor agonist; MBS, metabolic bariatric surgery; T1D, type 1 diabetes; T2D, type 2 diabetes; SPK, simultaneous pancreas and kidney transplant.
January 26, 2026 at 11:02 AM
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Mini Review by Kristen L. Nowak and Michel Chonchol:

Targeting Inflammation in CKD

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Inflammatory Signaling and Potential Therapeutic Targets in CKD. Sterile inflammation triggered by innate immune system activation is a key driver of both chronic kidney disease (CKD) and associated atherosclerosis and cardiovascular disease (CVD), in part via activation of the NLRP3 inflammasome. Recent and ongoing clinical trials are testing therapeutics targeting the NLRP3 inflammasome, interleukin-1 (IL-1) and its receptor (IL-1R), interleukin-6 (IL-6) and its receptor (IL6R), as represented in this schematic.
January 25, 2026 at 11:00 PM