Journal of Bone Marrow Transplantation and Cellular Therapy
@jbmtct.bsky.social
The Journal of Bone Marrow Transplantation and Cellular Therapy is the official vehicle for disseminating scientific information from the Brazilian Society of Bone Marrow Transplantation (SBTMO).
🩸This study shows that hematopoietic cell transplantation is curative for >150 inborn errors of immunity. In Wiskott–Aldrich syndrome, early transplant achieves ~91% 5-year survival, especially with robust donor myeloid chimerism.
doi.org/10.46765/267...
#HSCT #HemeOnc #HemeSky #MedSky #JBMTCT
doi.org/10.46765/267...
#HSCT #HemeOnc #HemeSky #MedSky #JBMTCT
December 24, 2025 at 1:20 PM
This study demonstrates that alterations in the RAS-MAPK pathway guide prognosis & treatment. PTPN11 & NF1 cases require early allogeneic HCT, the only curative option, while KRAS/NRAS allow individualized management.
Access the full free article at doi.org/10.46765/267...
#HemeOnc #HemeSky #MedSky
Access the full free article at doi.org/10.46765/267...
#HemeOnc #HemeSky #MedSky
December 22, 2025 at 2:15 PM
This study demonstrates that alterations in the RAS-MAPK pathway guide prognosis & treatment. PTPN11 & NF1 cases require early allogeneic HCT, the only curative option, while KRAS/NRAS allow individualized management.
Access the full free article at doi.org/10.46765/267...
#HemeOnc #HemeSky #MedSky
Access the full free article at doi.org/10.46765/267...
#HemeOnc #HemeSky #MedSky
Can less intensive therapy improve outcomes in older adults with AML? A Brazilian public hospital study found that low-intensity regimens with venetoclax achieved a median survival of ~11 months, vs ~1 month with intensive chemotherapy or supportive care alone. #Hematology
doi.org/10.46765/267...
doi.org/10.46765/267...
December 19, 2025 at 1:57 PM
Can less intensive therapy improve outcomes in older adults with AML? A Brazilian public hospital study found that low-intensity regimens with venetoclax achieved a median survival of ~11 months, vs ~1 month with intensive chemotherapy or supportive care alone. #Hematology
doi.org/10.46765/267...
doi.org/10.46765/267...
🩸Hematopoietic cell transplantation is the only curative therapy for selected pediatric inborn errors of metabolism & osteopetrosis. Early diagnosis and timely transplantation are essential to prevent irreversible neurological damage through sustained enzyme cross-correction.
doi.org/10.46765/267...
doi.org/10.46765/267...
December 17, 2025 at 1:37 PM
🩸Hematopoietic cell transplantation is the only curative therapy for selected pediatric inborn errors of metabolism & osteopetrosis. Early diagnosis and timely transplantation are essential to prevent irreversible neurological damage through sustained enzyme cross-correction.
doi.org/10.46765/267...
doi.org/10.46765/267...
⏳Why does timing matter in SCI?
Early HCT, performed before active infections, is associated with improved survival. Haploidentical transplants show higher toxicity, highlighting the need for early diagnosis and expert centers.
doi.org/10.46765/267...
#ImmunodeficiencyDiseases #Immunology #JBMTCT
Early HCT, performed before active infections, is associated with improved survival. Haploidentical transplants show higher toxicity, highlighting the need for early diagnosis and expert centers.
doi.org/10.46765/267...
#ImmunodeficiencyDiseases #Immunology #JBMTCT
December 15, 2025 at 1:47 PM
⏳Why does timing matter in SCI?
Early HCT, performed before active infections, is associated with improved survival. Haploidentical transplants show higher toxicity, highlighting the need for early diagnosis and expert centers.
doi.org/10.46765/267...
#ImmunodeficiencyDiseases #Immunology #JBMTCT
Early HCT, performed before active infections, is associated with improved survival. Haploidentical transplants show higher toxicity, highlighting the need for early diagnosis and expert centers.
doi.org/10.46765/267...
#ImmunodeficiencyDiseases #Immunology #JBMTCT
Children who reached complete or partial remission before HDCT/ASCT showed a 5-year overall survival of 62.5%, while those with progressive disease had 0% event-free survival. Pre-transplant response is a decisive prognostic factor.
👀Read the full free article at doi.org/10.46765/267...
#Pediatrics
👀Read the full free article at doi.org/10.46765/267...
#Pediatrics
December 12, 2025 at 2:31 PM
Children who reached complete or partial remission before HDCT/ASCT showed a 5-year overall survival of 62.5%, while those with progressive disease had 0% event-free survival. Pre-transplant response is a decisive prognostic factor.
👀Read the full free article at doi.org/10.46765/267...
#Pediatrics
👀Read the full free article at doi.org/10.46765/267...
#Pediatrics
Allogeneic hematopoietic stem cell transplantation🩸 is the only curative therapy for many children with Myelodysplastic Syndrome, especially MDS with excess blasts, achieving a 5-year overall survival of up to 63%.
🆓Read the free full article at
doi.org/10.46765/267...
#hematology #pedriatics
🆓Read the free full article at
doi.org/10.46765/267...
#hematology #pedriatics
December 10, 2025 at 5:26 PM
Allogeneic hematopoietic stem cell transplantation🩸 is the only curative therapy for many children with Myelodysplastic Syndrome, especially MDS with excess blasts, achieving a 5-year overall survival of up to 63%.
🆓Read the free full article at
doi.org/10.46765/267...
#hematology #pedriatics
🆓Read the free full article at
doi.org/10.46765/267...
#hematology #pedriatics
The Brazilian consensus reaffirms that HLA-matched sibling donor hematopoietic stem cell transplantation remains the first-line therapy for pediatric patients, offering a long-term survival rate of greater than 90%.
🔓Read more for free at
doi.org/10.46765/267...
#JBMTCT #SevereAplasticAnemia
🔓Read more for free at
doi.org/10.46765/267...
#JBMTCT #SevereAplasticAnemia
December 8, 2025 at 1:30 PM
The Brazilian consensus reaffirms that HLA-matched sibling donor hematopoietic stem cell transplantation remains the first-line therapy for pediatric patients, offering a long-term survival rate of greater than 90%.
🔓Read more for free at
doi.org/10.46765/267...
#JBMTCT #SevereAplasticAnemia
🔓Read more for free at
doi.org/10.46765/267...
#JBMTCT #SevereAplasticAnemia
Brazil developed a structured #HCT Data Manager Manual to standardize CIBMTR reporting. The tool received high approval (9.3/10) and is now available in print, digital, and Spanish, with an English version underway.
🔓https://doi.org/10.46765/2675-374X.2025v6n1e281
@cibmtr.bsky.social #hematology
🔓https://doi.org/10.46765/2675-374X.2025v6n1e281
@cibmtr.bsky.social #hematology
December 5, 2025 at 12:46 PM
Brazil developed a structured #HCT Data Manager Manual to standardize CIBMTR reporting. The tool received high approval (9.3/10) and is now available in print, digital, and Spanish, with an English version underway.
🔓https://doi.org/10.46765/2675-374X.2025v6n1e281
@cibmtr.bsky.social #hematology
🔓https://doi.org/10.46765/2675-374X.2025v6n1e281
@cibmtr.bsky.social #hematology
❓Is it possible to cure pediatric #thalassemia even w/o a fully matched family donor? This study shows that transplants from matched unrelated donors can achieve success rates approaching 90%, expanding access to curative therapy.
🆓https://doi.org/10.46765/2675-374X.2025v6n1e292
#Hematology #JBMTCT
🆓https://doi.org/10.46765/2675-374X.2025v6n1e292
#Hematology #JBMTCT
December 3, 2025 at 2:12 PM
❓Is it possible to cure pediatric #thalassemia even w/o a fully matched family donor? This study shows that transplants from matched unrelated donors can achieve success rates approaching 90%, expanding access to curative therapy.
🆓https://doi.org/10.46765/2675-374X.2025v6n1e292
#Hematology #JBMTCT
🆓https://doi.org/10.46765/2675-374X.2025v6n1e292
#Hematology #JBMTCT
The article highlights that up to 80% of children undergoing hematopoietic stem cell transplantation🩸develop painful lesions in the oral mucosa between 5 and 10 days after the start of the conditioning regimen, with a peak between days 12 and 14.
🆓https://doi.org/10.46765/2675-374X.2025v6n1e283
🆓https://doi.org/10.46765/2675-374X.2025v6n1e283
December 1, 2025 at 2:00 PM
The article highlights that up to 80% of children undergoing hematopoietic stem cell transplantation🩸develop painful lesions in the oral mucosa between 5 and 10 days after the start of the conditioning regimen, with a peak between days 12 and 14.
🆓https://doi.org/10.46765/2675-374X.2025v6n1e283
🆓https://doi.org/10.46765/2675-374X.2025v6n1e283
HDCT + Auto-HCT for pediatric CNS tumors? 🧠
👉Key finding ( <5 years, high-risk embryonal): Improves disease control while permitting RT reduction/delay.
👉Result: Minimizes neurocognitive toxicity without sacrificing efficacy.
Read the full free article at doi.org/10.46765/267...
#oncology #children
👉Key finding ( <5 years, high-risk embryonal): Improves disease control while permitting RT reduction/delay.
👉Result: Minimizes neurocognitive toxicity without sacrificing efficacy.
Read the full free article at doi.org/10.46765/267...
#oncology #children
November 28, 2025 at 1:16 PM
HDCT + Auto-HCT for pediatric CNS tumors? 🧠
👉Key finding ( <5 years, high-risk embryonal): Improves disease control while permitting RT reduction/delay.
👉Result: Minimizes neurocognitive toxicity without sacrificing efficacy.
Read the full free article at doi.org/10.46765/267...
#oncology #children
👉Key finding ( <5 years, high-risk embryonal): Improves disease control while permitting RT reduction/delay.
👉Result: Minimizes neurocognitive toxicity without sacrificing efficacy.
Read the full free article at doi.org/10.46765/267...
#oncology #children
The new Brazilian consensus outlines lifelong care for pediatric hematopoietic stem cell transplant survivors, prioritizing high-risk groups. It emphasizes GVHD surveillance, multisystem late-effect monitoring, & other aspects w/in a standardized, multidisciplinary framework.
doi.org/10.46765/267...
doi.org/10.46765/267...
November 26, 2025 at 5:44 PM
The new Brazilian consensus outlines lifelong care for pediatric hematopoietic stem cell transplant survivors, prioritizing high-risk groups. It emphasizes GVHD surveillance, multisystem late-effect monitoring, & other aspects w/in a standardized, multidisciplinary framework.
doi.org/10.46765/267...
doi.org/10.46765/267...
🩸This study shows that hematopoietic cell transplantation is the only curative option for blood complications, with better outcomes when done early and with reduced-toxicity regimens.
🔓https://doi.org/10.46765/2675-374X.2025v6n1e288
#FanconiAnemia #DyskeratosisCongenita #Anemia #Hematology #JBMTCT
🔓https://doi.org/10.46765/2675-374X.2025v6n1e288
#FanconiAnemia #DyskeratosisCongenita #Anemia #Hematology #JBMTCT
November 24, 2025 at 6:03 PM
🩸This study shows that hematopoietic cell transplantation is the only curative option for blood complications, with better outcomes when done early and with reduced-toxicity regimens.
🔓https://doi.org/10.46765/2675-374X.2025v6n1e288
#FanconiAnemia #DyskeratosisCongenita #Anemia #Hematology #JBMTCT
🔓https://doi.org/10.46765/2675-374X.2025v6n1e288
#FanconiAnemia #DyskeratosisCongenita #Anemia #Hematology #JBMTCT
Early monitoring of minimal residual disease and donor chimerism helps detect relapse risk sooner in children after stem cell transplant, enabling timely interventions that improve outcomes.
🆓Read the full article at doi.org/10.46765/267...
#leukemia #neoplasm #chimerism #pediatric #JBMTCT
🆓Read the full article at doi.org/10.46765/267...
#leukemia #neoplasm #chimerism #pediatric #JBMTCT
November 21, 2025 at 11:44 AM
Early monitoring of minimal residual disease and donor chimerism helps detect relapse risk sooner in children after stem cell transplant, enabling timely interventions that improve outcomes.
🆓Read the full article at doi.org/10.46765/267...
#leukemia #neoplasm #chimerism #pediatric #JBMTCT
🆓Read the full article at doi.org/10.46765/267...
#leukemia #neoplasm #chimerism #pediatric #JBMTCT
🩸 Allogeneic hematopoietic cell transplantation remains the only curative therapy for #sicklecelldisease. The new 2025 Brazilian consensus highlights advances in conditioning regimens & the use of haploidentical donors with post-transplant cyclophosphamide. #hematology
doi.org/10.46765/267...
doi.org/10.46765/267...
November 14, 2025 at 2:04 PM
🩸 Allogeneic hematopoietic cell transplantation remains the only curative therapy for #sicklecelldisease. The new 2025 Brazilian consensus highlights advances in conditioning regimens & the use of haploidentical donors with post-transplant cyclophosphamide. #hematology
doi.org/10.46765/267...
doi.org/10.46765/267...
💊New article highlights the crucial role of pharmacists in hematopoietic stem cell transplantation. They guide patients through all treatment phases, managing polypharmacy & high infection risks. Pharmacists are essential for medication safety and reducing errors.
doi.org/10.46765/267...
doi.org/10.46765/267...
November 12, 2025 at 6:50 PM
💊New article highlights the crucial role of pharmacists in hematopoietic stem cell transplantation. They guide patients through all treatment phases, managing polypharmacy & high infection risks. Pharmacists are essential for medication safety and reducing errors.
doi.org/10.46765/267...
doi.org/10.46765/267...
👩⚕️Occupational therapy in a #pediatric chronic cGVHD case led to the acquisition of ambulation and improved fine motor skills. Early intervention is crucial!
👀Read the free full article at doi.org/10.46765/267...
#ocupationaltherapy #rehabilitation #stemcelltransplant
👀Read the free full article at doi.org/10.46765/267...
#ocupationaltherapy #rehabilitation #stemcelltransplant
November 7, 2025 at 7:29 PM
👩⚕️Occupational therapy in a #pediatric chronic cGVHD case led to the acquisition of ambulation and improved fine motor skills. Early intervention is crucial!
👀Read the free full article at doi.org/10.46765/267...
#ocupationaltherapy #rehabilitation #stemcelltransplant
👀Read the free full article at doi.org/10.46765/267...
#ocupationaltherapy #rehabilitation #stemcelltransplant
🥶 #Cryopreservation of stem cells in #Brazil: study reveals significant heterogeneity in freezing practices among centers. Although 75% cryopreserve within 24h, the "recipes" (solutions and concentrations) are diverse. Standardization is key to greater safety and efficacy!
doi.org/10.46765/267...
doi.org/10.46765/267...
November 5, 2025 at 2:29 PM
🥶 #Cryopreservation of stem cells in #Brazil: study reveals significant heterogeneity in freezing practices among centers. Although 75% cryopreserve within 24h, the "recipes" (solutions and concentrations) are diverse. Standardization is key to greater safety and efficacy!
doi.org/10.46765/267...
doi.org/10.46765/267...
Is Loes Score the only rule for X-ALD transplant? 🤔
New case study: patient with a high score (12) but good neurological function had a successful Hematopoietic Stem Cell Transplantation (HSCT). The takeaway? Clinical status is paramount, not just the score on the scan.
🆓 doi.org/10.46765/267...
New case study: patient with a high score (12) but good neurological function had a successful Hematopoietic Stem Cell Transplantation (HSCT). The takeaway? Clinical status is paramount, not just the score on the scan.
🆓 doi.org/10.46765/267...
October 30, 2025 at 3:41 PM
Is Loes Score the only rule for X-ALD transplant? 🤔
New case study: patient with a high score (12) but good neurological function had a successful Hematopoietic Stem Cell Transplantation (HSCT). The takeaway? Clinical status is paramount, not just the score on the scan.
🆓 doi.org/10.46765/267...
New case study: patient with a high score (12) but good neurological function had a successful Hematopoietic Stem Cell Transplantation (HSCT). The takeaway? Clinical status is paramount, not just the score on the scan.
🆓 doi.org/10.46765/267...
Study highlights the incorporation of Eculizumab into the Brazilian public health system (SUS) in 2018 for Paroxysmal Nocturnal Hemoglobinuria (PNH)🩸.
Access requires strict criteria (e.g., LDH ≥ 1.5x UL). A crucial advance for patients!
🔓Full article at doi.org/10.46765/267...
#SUS #Brazil
Access requires strict criteria (e.g., LDH ≥ 1.5x UL). A crucial advance for patients!
🔓Full article at doi.org/10.46765/267...
#SUS #Brazil
October 28, 2025 at 1:27 PM
Study highlights the incorporation of Eculizumab into the Brazilian public health system (SUS) in 2018 for Paroxysmal Nocturnal Hemoglobinuria (PNH)🩸.
Access requires strict criteria (e.g., LDH ≥ 1.5x UL). A crucial advance for patients!
🔓Full article at doi.org/10.46765/267...
#SUS #Brazil
Access requires strict criteria (e.g., LDH ≥ 1.5x UL). A crucial advance for patients!
🔓Full article at doi.org/10.46765/267...
#SUS #Brazil
Brazil is the largest bone marrow transplant provider in Latin America. But is access to this vital treatment equal for everyone? In this study, the authors analyzed the current scenario of hematopoietic stem cell transplantation in the country & presented the challenges.
doi.org/10.46765/267...
doi.org/10.46765/267...
October 23, 2025 at 2:36 PM
Brazil is the largest bone marrow transplant provider in Latin America. But is access to this vital treatment equal for everyone? In this study, the authors analyzed the current scenario of hematopoietic stem cell transplantation in the country & presented the challenges.
doi.org/10.46765/267...
doi.org/10.46765/267...
Reposted by Journal of Bone Marrow Transplantation and Cellular Therapy
Sharpen your diagnostic accuracy and personalize therapy decisions for your patients with acute lymphoblastic leukemia and lineage ambiguous leukemia.
ASH connects you with experts in precision hematology. Don't miss it! https://ow.ly/uqyX50Xf4NZ
#Hemesky #Medsky #Leusm #PrecisionHeme #Lymsm
ASH connects you with experts in precision hematology. Don't miss it! https://ow.ly/uqyX50Xf4NZ
#Hemesky #Medsky #Leusm #PrecisionHeme #Lymsm
October 23, 2025 at 11:55 AM
Sharpen your diagnostic accuracy and personalize therapy decisions for your patients with acute lymphoblastic leukemia and lineage ambiguous leukemia.
ASH connects you with experts in precision hematology. Don't miss it! https://ow.ly/uqyX50Xf4NZ
#Hemesky #Medsky #Leusm #PrecisionHeme #Lymsm
ASH connects you with experts in precision hematology. Don't miss it! https://ow.ly/uqyX50Xf4NZ
#Hemesky #Medsky #Leusm #PrecisionHeme #Lymsm
🚀CAR-T cell therapy is showing promising results in #Brazil for lymphoma and leukemia patients, with survival rates of 73% and 79%. This advanced treatment offers new hope where other options have failed.
🔓https://doi.org/10.46765/2675-374X.2025v6n1p271
#CARTCells #CellTherapy #CancerTreatment
🔓https://doi.org/10.46765/2675-374X.2025v6n1p271
#CARTCells #CellTherapy #CancerTreatment
October 15, 2025 at 11:20 PM
🚀CAR-T cell therapy is showing promising results in #Brazil for lymphoma and leukemia patients, with survival rates of 73% and 79%. This advanced treatment offers new hope where other options have failed.
🔓https://doi.org/10.46765/2675-374X.2025v6n1p271
#CARTCells #CellTherapy #CancerTreatment
🔓https://doi.org/10.46765/2675-374X.2025v6n1p271
#CARTCells #CellTherapy #CancerTreatment
Are Brazilian HCT outcomes on par with global standards? Yes! A new study of 11,210 transplants (2012-2023) shows 2-year overall survival rates of 82.0% (autologous) and 59.8% (allogeneic), matching international benchmarks. Quality care in Brazil! #bonemarrowtransplant
doi.org/10.46765/267...
doi.org/10.46765/267...
October 8, 2025 at 10:35 PM
Are Brazilian HCT outcomes on par with global standards? Yes! A new study of 11,210 transplants (2012-2023) shows 2-year overall survival rates of 82.0% (autologous) and 59.8% (allogeneic), matching international benchmarks. Quality care in Brazil! #bonemarrowtransplant
doi.org/10.46765/267...
doi.org/10.46765/267...