Greg Jefferis
@jefferis.bsky.social
780 followers 450 following 22 posts
Neural Circuits and Behaviour in Drosophila @ MRC LMB. PI @ flyconnectome @ CamZoology and @ virtualflybrain. Cambridge, UK. Previously @gsxej.
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jefferis.bsky.social
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
jefferis.bsky.social
Wow congratulations @jkohl.bsky.social! Proud scientific parent :)
fens.org
The #HertieFoundation and #FENS are excited to announce the winner of the Eric Kandel Young Neuroscientists Prize 2025: Johannes Kohl!

He will be awarded EUR 100,000 and will deliver the Eric Kandel Prize Lecture at #FENS2026 in Barcelona! 🇪🇸

👉 https://loom.ly/xsDFNzo
jefferis.bsky.social
And here's the official announcement from our Janelia collaborators with a fantastic visualisation from @philiphubbard.bsky.social. See more at male-cns.janelia.org/media. Downloads are humming and we have solved the first data access queries. Happy exploring! #drosophila #connectomics #malecns.
Reposted by Greg Jefferis
janelia-flyem.bsky.social
We're very proud to be releasing the complete male fly CNS connectome!

It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators.

More soon...
www.janelia.org/project-team...
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
jefferis.bsky.social
Comparison with previous female connectomes reveals sex differences across the adult brain at synaptic resolution for the first time. Full news story and preprint describing this massive team effort coming soon!
jefferis.bsky.social
This dataset provides two major advances. It is the first fully proofread and annotated brain and nerve cord connectome with 166,696 proofread neurons annotated with 11,691 cell types. It is also the first connectome of a male brain.
jefferis.bsky.social
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
Reposted by Greg Jefferis
djabaudon.bsky.social
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT

neuro-unige.ch/news/csf-mee...
jefferis.bsky.social
Congratulations. Sorry that I won’t have the chance to bump into you at Bob’s anymore but hope the move goes really well!
jefferis.bsky.social
Those darned Europeans …
jefferis.bsky.social
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
Reposted by Greg Jefferis
tobiasuhauser.bsky.social
📢 We are hiring! 📢
For our @wellcometrust.bsky.social grant on information gathering biases in #OCD and #Schizophrenia, we are looking for a Postdoc in Computational Modelling, supervised by Peter Dayan and myself.
Interested? See all the details in the job advert here: devcompsy.org/wp-content/u...
a penguin is sticking his head out of a hole next to a job application
ALT: a penguin is sticking his head out of a hole next to a job application
media.tenor.com
Reposted by Greg Jefferis
dddavi.bsky.social
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)

thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
Reposted by Greg Jefferis
hansonmark.bsky.social
"The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades."

4000 labs is a severe understatement, likely off by an order of magnitude. Even non-fly people use and benefit from FlyBase. It is one of the cornerstones of the genome era.
Reposted by Greg Jefferis
darbly.bsky.social
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.

Preprint: doi.org/10.1101/2025...

#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Diagrams (top-left) of an adult female Ae. aegypti head and (bottom) a basiconic sensillum on maxillary palp (gray) which contain dendritic processes of olfactory sensory neurons (OSNs), including CO2-sensitive Gr3-expressing OSNs. OSN axons project centrally to the antennal lobes in the brain. On the right is a volumetric rendering of the mosquito brain neuropils including the antennal lobes (light blue) (Heinze et al., 2021; Matthews et al., 2019). Scale bar 100 μm.
Reposted by Greg Jefferis
claudiomics.bsky.social
We are looking for 2 postdocs to join my lab at Sussex University in Brighton, UK (South of London, on the sea). One position is for a molecular/cell biologist, the other, for a neurobiologist/behavioural person. Drosophila experience desirable. Flyer w/more info below. Please repost. Thank you!
Reposted by Greg Jefferis
philholliger.bsky.social
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
Reposted by Greg Jefferis
resprofnews.bsky.social
Big story breaking this evening.

Alan Turing Institute told to focus on defence or lose funding.

The science secretary Peter Kyle has threatened to pull defence R&D funds, while reforms could see EPSRC grant revisited.

Free to read.

www.researchprofessionalnews.com/rr-news-uk-p...
Alan Turing Institute told to focus on defence or lose funding - Research Professional News
Science secretary threatens to pull defence R&D funds, while reforms could see EPSRC grant revisited
www.researchprofessionalnews.com
Reposted by Greg Jefferis
jekely.biologists.social.ap.brid.gy
In our new preprint we describe the synaptic #connectome of the nerve net in the ctenophore gravisensory organ. https://www.biorxiv.org/content/10.1101/2025.06.26.661250v1 #biology #neuroscience #ctenophore #vem
Volume rendering of the ctenophore aboral organ reconstructed by volume EM, showing the gravisensory balancers and the four quadrants.
Reposted by Greg Jefferis
camzoology.bsky.social
🎉We are delighted to announce that Professor Stephen Montgomery @ebablab.bsky.social‬ will be the 3rd Prince Philip Professor of Ecology and Evolution.

We look forward to welcoming him next year!
Reposted by Greg Jefferis
Great job opportunity at The Center for Integrative Genomics, Lausanne University, Switzerland unil.ch/cig/en/home....
For a tenure-track Assistant Professor position. More details for how to apply are here nature.com/naturecareer...
Reposted by Greg Jefferis
ebablab.bsky.social
🚨Anyone want a job?🚨
We have two #postdocs up for grabs! 🧪
- cell developmental biology/#evodevo/#neuroevodevo
- bioinformatics and molecular biology
Both working on brain evolution in Heliconiini butterflies
Details below! Please repost 🙏 1/n