Jérôme Salignon
@jeromesalignon.bsky.social
Pinned
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵👇
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh
bsky.app/profile/jero...
bsky.app/profile/jero...
doi.org
June 9, 2025 at 2:01 PM
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh
bsky.app/profile/jero...
bsky.app/profile/jero...
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
June 9, 2025 at 1:36 PM
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
Pasta, an age-shift transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation
As the prevalence of age-related diseases rises, understanding and modulating the aging process is becoming a priority. Transcriptomic aging clocks (TACs) hold great promise for this endeavor, yet mos...
doi.org
June 9, 2025 at 1:33 PM
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵 bsky.app/profile/jero...
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵👇
June 5, 2025 at 10:03 AM
Can we measure & shift a cell’s age? Meet Pasta, a plug-and-play transcriptomic clock that flags perturbations that ↑ (cancer therapy) or ↓ (regenerative medicine) biological age. doi.org/pqhh #aging #AI 🧵👇
Reposted by Jérôme Salignon
🚨 Pre-print alert! 🚨
We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90.
These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬
🧵👇
We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90.
These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬
🧵👇
April 16, 2025 at 6:05 PM
🚨 Pre-print alert! 🚨
We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90.
These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬
🧵👇
We generated chromosome-scale diploid genome assemblies for the widely used fibroblast lines BJ and IMR-90.
These models of replicative senescence and telomere shortening now have fully resolved telomeres, subtelomeres, and centromeres. 🧬
🧵👇
Reposted by Jérôme Salignon
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩🔬🧪🔬🥼👨🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent
Full details 👇 ✨️
www.nature.com/articles/s41...
Full details 👇 ✨️
www.nature.com/articles/s41...
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations - npj Aging
npj Aging - Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
www.nature.com
November 23, 2024 at 11:02 PM
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩🔬🧪🔬🥼👨🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent
Full details 👇 ✨️
www.nature.com/articles/s41...
Full details 👇 ✨️
www.nature.com/articles/s41...