Key finding 5: Sensory-association imbalance is a promising cognitive biomarker for prognosis/monitoring because 1) higher imbalance at baseline predicts accelerated cognitive decline and 2) functional biomarkers will likely show more dynamic response to treatment.

Key finding 4: Structure and function biomarker scores both contribute to cognitive impairment.

Key finding 3: Eigenmode analysis reveals reductions in gradient amplitude and phase, which we call collapse. Those disruptions that add up to observed FC differences.

Key finding 2: Hypo and hyperconnectivity appear as two sides of the same coin. Different atrophy patterns perturb specific functional gradients, in which anticorrelated network pairs are embedded.

Key finding 1: Sensory-association functional connectivity imbalance (SAI) appears in all syndromes. As atrophy increases, sensory connectivity weakens and association connectivity gets stronger. Did not expect this.

We mapped structure-function relationships in Alzheimer’s disease and frontotemporal dementia. This was a good cohort because the atrophy patterns collectively cover almost the entire brain.

Stimulating the LGN with ultrasound and real-time fMRI, this is cool.

Ultrasound system for precise neuromodulation of human deep brain circuits.
www.nature.com/articles/s41...

Enjoying this, giving me 1996 feels and hope for the next wave.