Journal of Human Immunity
@jhumimmunity.org
Journal of Human Immunity (JHI) is the official open access journal of the International Alliance for Primary Immunodeficiency Societies (IAPIDS). Published by @rupress.org 🌐 jhumimmunity.org
Markers of immune dysregulation in pediatric patients with severe #bronchiolitis. New report from Katherine Hickey, Dusan Bogunovic @bogunoviclab.bsky.social and colleagues: rupress.org/jhi/article/...
January 13, 2026 at 9:15 PM
Markers of immune dysregulation in pediatric patients with severe #bronchiolitis. New report from Katherine Hickey, Dusan Bogunovic @bogunoviclab.bsky.social and colleagues: rupress.org/jhi/article/...
Viral infection and brain #inflammation with seizures in PARK7 deficiency. New study from Jonas Lønskov, Annika Sünderhauf, Sisse Andersen, Trine H. Mogensen @au.dk and colleagues: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #SevereImmunodeficiencies
#InbornErrorsOfImmunity #SevereImmunodeficiencies
January 13, 2026 at 8:15 PM
Viral infection and brain #inflammation with seizures in PARK7 deficiency. New study from Jonas Lønskov, Annika Sünderhauf, Sisse Andersen, Trine H. Mogensen @au.dk and colleagues: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #SevereImmunodeficiencies
#InbornErrorsOfImmunity #SevereImmunodeficiencies
Immune dysregulation from a novel CTLA-4 haploinsufficiency variant. New study from Nina N. Brodsky, Saquib A. Lakhani and colleagues @yaleschoolofmed.bsky.social: rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
January 13, 2026 at 8:03 PM
Immune dysregulation from a novel CTLA-4 haploinsufficiency variant. New study from Nina N. Brodsky, Saquib A. Lakhani and colleagues @yaleschoolofmed.bsky.social: rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
Good? A very long #COVID19. A new case report from Quentin Philippot and colleagues @upcite.bsky.social: rupress.org/jhi/article/...
#SARSCoV2
#SARSCoV2
January 13, 2026 at 7:30 PM
Good? A very long #COVID19. A new case report from Quentin Philippot and colleagues @upcite.bsky.social: rupress.org/jhi/article/...
#SARSCoV2
#SARSCoV2
Ho, Cunningham-Rundles et al. show that bacterial transcytosis in common variable immune deficiency leads to the production of IFN-gamma and other inflammatory signals in subjects who develop the non-infectious complications found in this immune defect. rupress.org/jhi/article/...
#CVID
#CVID
January 13, 2026 at 5:30 PM
Ho, Cunningham-Rundles et al. show that bacterial transcytosis in common variable immune deficiency leads to the production of IFN-gamma and other inflammatory signals in subjects who develop the non-infectious complications found in this immune defect. rupress.org/jhi/article/...
#CVID
#CVID
In Memoriam: Richard A. Gatti, MD (1937–2025). Alessandro Aiuti and Luigi D. Notarangelo commemorate the passing of Dr. Richard Gatti, who was a visionary in #immunology and #genetics whose work reshaped the understanding and treatment of inherited immune diseases. rupress.org/jhi/article/...
January 13, 2026 at 3:15 PM
In Memoriam: Richard A. Gatti, MD (1937–2025). Alessandro Aiuti and Luigi D. Notarangelo commemorate the passing of Dr. Richard Gatti, who was a visionary in #immunology and #genetics whose work reshaped the understanding and treatment of inherited immune diseases. rupress.org/jhi/article/...
New from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...
#InnateImmunity
#InnateImmunity
January 12, 2026 at 5:45 PM
New from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...
#InnateImmunity
#InnateImmunity
Groen, @benhale.bsky.social et al. @virology.uzh.ch identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
January 12, 2026 at 5:01 PM
Groen, @benhale.bsky.social et al. @virology.uzh.ch identify interferon-λ #autoantibodies in 11.8% of those with #CysticFibrosis, a prevalence >10-fold higher than expected. In vitro & clinical analyses suggest the antibodies may impact mucosal pathology. rupress.org/jhi/article/...
Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two conditions. rupress.org/jhi/article/...
January 8, 2026 at 5:00 PM
Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two conditions. rupress.org/jhi/article/...
Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...
#Autoimmunity #InbornErrorsOfImmunity
#Autoimmunity #InbornErrorsOfImmunity
January 7, 2026 at 4:00 PM
Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...
#Autoimmunity #InbornErrorsOfImmunity
#Autoimmunity #InbornErrorsOfImmunity
#InMemoriam Remembering Richard A. Gatti, MD, a pioneer of clinical immunology and hematopoietic stem cell transplantation, whose landmark contributions transformed the diagnosis and treatment of rare immune and DNA repair disorders. By Aiuti and Notarangelo: rupress.org/jhi/article/...
January 6, 2026 at 6:01 PM
#InMemoriam Remembering Richard A. Gatti, MD, a pioneer of clinical immunology and hematopoietic stem cell transplantation, whose landmark contributions transformed the diagnosis and treatment of rare immune and DNA repair disorders. By Aiuti and Notarangelo: rupress.org/jhi/article/...
Children w/ #bronchiolitis exhibit a unique immunophenotype. Hickey, @bogunoviclab.bsky.social et al identify a significant difference in plasmacytoid #DendriticCells & #eosinophils in hospitalized patients, plus differences in cytokines involved in airway #inflammation rupress.org/jhi/article/...
January 6, 2026 at 3:45 PM
Children w/ #bronchiolitis exhibit a unique immunophenotype. Hickey, @bogunoviclab.bsky.social et al identify a significant difference in plasmacytoid #DendriticCells & #eosinophils in hospitalized patients, plus differences in cytokines involved in airway #inflammation rupress.org/jhi/article/...
Lønskov, Sünderhauf, Andersen, Mogensen et al. describe a child homozygous for a deleterious variant in PARK7/DJ-1 presenting with #RSV infection, brain #inflammation, and seizures and explore the pathophysiology of PARK7 deficiency. rupress.org/jhi/article/...
#InbornErrorsofImmunity
#InbornErrorsofImmunity
January 6, 2026 at 3:15 PM
Lønskov, Sünderhauf, Andersen, Mogensen et al. describe a child homozygous for a deleterious variant in PARK7/DJ-1 presenting with #RSV infection, brain #inflammation, and seizures and explore the pathophysiology of PARK7 deficiency. rupress.org/jhi/article/...
#InbornErrorsofImmunity
#InbornErrorsofImmunity
Brodsky, Lakhani et al. @yaleschoolofmed.bsky.social describe immune dysregulation from a novel C-terminal cytoplasmic CTLA-4 haploinsufficiency variant. rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
January 6, 2026 at 2:45 PM
Brodsky, Lakhani et al. @yaleschoolofmed.bsky.social describe immune dysregulation from a novel C-terminal cytoplasmic CTLA-4 haploinsufficiency variant. rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
Philippot et al. report a case of chronic pulmonary #SARSCoV2 infection caused by impaired B cell–mediated immunity to SARS-CoV-2 in a patient with Good syndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical and radiological resolution. rupress.org/jhi/article/...
January 6, 2026 at 2:30 PM
Philippot et al. report a case of chronic pulmonary #SARSCoV2 infection caused by impaired B cell–mediated immunity to SARS-CoV-2 in a patient with Good syndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical and radiological resolution. rupress.org/jhi/article/...
JHI’s January Issue is here! rupress.org/jhi/issue/2/1
The cover image shows DNA methylation alterations in B cells in ICF syndrome and other primary #immunodeficiencies. From Martins-Ferreira and @eballestar.bsky.social: doi.org/10.70962/jhi...
The cover image shows DNA methylation alterations in B cells in ICF syndrome and other primary #immunodeficiencies. From Martins-Ferreira and @eballestar.bsky.social: doi.org/10.70962/jhi...
January 5, 2026 at 4:30 PM
JHI’s January Issue is here! rupress.org/jhi/issue/2/1
The cover image shows DNA methylation alterations in B cells in ICF syndrome and other primary #immunodeficiencies. From Martins-Ferreira and @eballestar.bsky.social: doi.org/10.70962/jhi...
The cover image shows DNA methylation alterations in B cells in ICF syndrome and other primary #immunodeficiencies. From Martins-Ferreira and @eballestar.bsky.social: doi.org/10.70962/jhi...
Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India. New study from Aparna Dalvi, Manisha Madkaikar (Indian Council of Medical Research National Institute of Immunohaematology) and colleagues: rupress.org/jhi/article/...
#Infections #Autoantibodies
#Infections #Autoantibodies
December 25, 2025 at 2:30 PM
Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India. New study from Aparna Dalvi, Manisha Madkaikar (Indian Council of Medical Research National Institute of Immunohaematology) and colleagues: rupress.org/jhi/article/...
#Infections #Autoantibodies
#Infections #Autoantibodies
Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency: A PIDTC study. From Virdette L. Brumm @ucsfchildrens.bsky.social, Ami J. Shah @stanfordmedicine.bsky.social and colleagues: rupress.org/jhi/article/...
#SCID
#SCID
December 24, 2025 at 7:30 PM
Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency: A PIDTC study. From Virdette L. Brumm @ucsfchildrens.bsky.social, Ami J. Shah @stanfordmedicine.bsky.social and colleagues: rupress.org/jhi/article/...
#SCID
#SCID
#HowITreat: Infections and #InbornErrorsOfImmunity—Prevention, diagnosis, and treatment. New practical advice from Alexandra Freeman @niaidnews.bsky.social, Beth Thielen @thie0149.bsky.social, and Tamara Pozos @childrensminnesota.bsky.social: rupress.org/jhi/article/...
@clinimmsoc.bsky.social
@clinimmsoc.bsky.social
December 23, 2025 at 4:30 PM
#HowITreat: Infections and #InbornErrorsOfImmunity—Prevention, diagnosis, and treatment. New practical advice from Alexandra Freeman @niaidnews.bsky.social, Beth Thielen @thie0149.bsky.social, and Tamara Pozos @childrensminnesota.bsky.social: rupress.org/jhi/article/...
@clinimmsoc.bsky.social
@clinimmsoc.bsky.social
🔔 We're pleased to share the abstracts from the Latin American Society for Immunodeficiencies Meeting 2025 @lasidofficial.bsky.social, which took place October 15–18, in Buenos Aires. Explore the latest advancements and insights in immunodeficiencies 👉 rupress.org/jhi/issue/1/...
December 23, 2025 at 3:15 PM
🔔 We're pleased to share the abstracts from the Latin American Society for Immunodeficiencies Meeting 2025 @lasidofficial.bsky.social, which took place October 15–18, in Buenos Aires. Explore the latest advancements and insights in immunodeficiencies 👉 rupress.org/jhi/issue/1/...
Brumm, Shah et al. evaluated 69 subjects with #SCID to assess the neurodevelopmental outcomes following HCT. Compared with the normative population, our subjects performed in the average range. There was no impact of newborn screening, conditioning, or genotype. rupress.org/jhi/article/...
December 18, 2025 at 5:02 PM
Brumm, Shah et al. evaluated 69 subjects with #SCID to assess the neurodevelopmental outcomes following HCT. Compared with the normative population, our subjects performed in the average range. There was no impact of newborn screening, conditioning, or genotype. rupress.org/jhi/article/...
Dalvi, Madkaikar et al. describe 50 Indian patients w/ Mendelian susceptibility to #mycobacterial disease, highlighting its clinical diversity & genetic heterogeneity. Immunological assays, flow cytometry & genetic testing aid diagnosis & targeted clinical management rupress.org/jhi/article/...
December 18, 2025 at 5:01 PM
Dalvi, Madkaikar et al. describe 50 Indian patients w/ Mendelian susceptibility to #mycobacterial disease, highlighting its clinical diversity & genetic heterogeneity. Immunological assays, flow cytometry & genetic testing aid diagnosis & targeted clinical management rupress.org/jhi/article/...
Clinical experience with #emapalumab treatment in a group of children with primary hemophagocytic lymphohistiocytosis. A new study from Yulia Rodina et al.: rupress.org/jhi/article/...
#Therapeutics #Hemophagocytosis
#Therapeutics #Hemophagocytosis
December 18, 2025 at 2:52 PM
Clinical experience with #emapalumab treatment in a group of children with primary hemophagocytic lymphohistiocytosis. A new study from Yulia Rodina et al.: rupress.org/jhi/article/...
#Therapeutics #Hemophagocytosis
#Therapeutics #Hemophagocytosis
Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...
#HowITreat
@clinimmsoc.bsky.social
#HowITreat
@clinimmsoc.bsky.social
December 16, 2025 at 7:58 PM
Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...
#HowITreat
@clinimmsoc.bsky.social
#HowITreat
@clinimmsoc.bsky.social
ICF syndrome: An epigenetic paradigm of primary immunodeficiencies. New review from Ricardo Martins-Ferreira and Esteban Ballestar @eballestar.bsky.social @carrerasijc.bsky.social: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology
#InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology
December 12, 2025 at 2:45 PM
ICF syndrome: An epigenetic paradigm of primary immunodeficiencies. New review from Ricardo Martins-Ferreira and Esteban Ballestar @eballestar.bsky.social @carrerasijc.bsky.social: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology
#InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology