Jialin Liu
@jialinliu.bsky.social
PostDoc
@schierlab.bsky.social, @biozentrum.unibas.ch
Single cell genomics, Deep learning, Gene Regulation, Embryonic Development
@schierlab.bsky.social, @biozentrum.unibas.ch
Single cell genomics, Deep learning, Gene Regulation, Embryonic Development
very cool method to detect positive selection on regulatory sequences!
I'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making!
Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃
https://doi.org/10.1101/2025.11.26.690685 #bioinformatics #MolecularEvolution
Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃
https://doi.org/10.1101/2025.11.26.690685 #bioinformatics #MolecularEvolution
December 3, 2025 at 6:31 PM
very cool method to detect positive selection on regulatory sequences!
Reposted by Jialin Liu
🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.
October 7, 2025 at 11:57 AM
🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.
Reposted by Jialin Liu
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 7:15 AM
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
Reposted by Jialin Liu
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos
Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...
www.biorxiv.org
June 2, 2025 at 4:13 PM
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
Reposted by Jialin Liu
Using a newly developed AI model, the research group @schierlab.bsky.social @biozentrum.unibas.ch @unibasel.ch has discovered in #zebrafish that certain sections of #mRNA control the extent of protein synthesis during early embryonic development. ow.ly/4zyU50V7v1c @cellpress.bsky.social
February 27, 2025 at 11:39 AM
Using a newly developed AI model, the research group @schierlab.bsky.social @biozentrum.unibas.ch @unibasel.ch has discovered in #zebrafish that certain sections of #mRNA control the extent of protein synthesis during early embryonic development. ow.ly/4zyU50V7v1c @cellpress.bsky.social
Reposted by Jialin Liu
The Genomic Code: the genome instantiates a generative model of the organism https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00008-3
February 12, 2025 at 7:30 PM
The Genomic Code: the genome instantiates a generative model of the organism https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00008-3
Reposted by Jialin Liu
Please spread the word: we have @snf-ch.bsky.social -funded #Postdoc and #PhD positions in our lab, to investigate the gene regulatory dynamics during vertebrate skeletogenesis in a comparative setting (see doi.org/10.1101/2024... doi.org/10.1101/2024... ) apply by 31.12.24, start date by 1.2.25!
December 3, 2024 at 12:26 PM
Please spread the word: we have @snf-ch.bsky.social -funded #Postdoc and #PhD positions in our lab, to investigate the gene regulatory dynamics during vertebrate skeletogenesis in a comparative setting (see doi.org/10.1101/2024... doi.org/10.1101/2024... ) apply by 31.12.24, start date by 1.2.25!
Reposted by Jialin Liu
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
November 26, 2024 at 3:49 PM
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)