jimlovesdystrophin.bsky.social
@jimlovesdystrophin.bsky.social
Reposted
I wanted to highlight our lab's recent #CommsBiology
manuscript: Conditional Dmd ablation in muscle and brain causes profound effects on muscle function and neurobehavior. Credit to Muthukumar Karuppasamy & all collaborators, and team. #Myoblue tinyurl.com/2f4s2ar7
Conditional Dmd ablation in muscle and brain causes profound effects on muscle function and neurobehavior - Communications Biology
Generation and characterization of a conditional dystrophin (Dmd) knockout mouse reveals myofiber-specific requirements for muscle homeostasis, and an essential role for Purkinje neuron Dmd in neurobe...
tinyurl.com
December 2, 2025 at 6:05 PM
Reposted
Mdx mice can produce dystrophin after treatments which target the DNA or RNA transcript like gene therapy and exon skipping. However, not after an anti-inflammatory treatment is given. This makes no sense and the fact that the authors do not realize this and the reviewers do not realize this is bad.
March 26, 2025 at 8:42 AM