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Joshua Mcbee

@jkmcbee.bsky.social

470 followers 950 following 100 posts

LCMS weirdo. Pretend expert in all things charged or separated. Biking aficionado, coffee enthusiast, destroyer of mass spectrometers.

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Joshua Mcbee @jkmcbee.bsky.social · 28d

I think they just created a big box o’ ions that they can eject when they are ready.

Joshua Mcbee @jkmcbee.bsky.social · Sep 4

Perhaps it’s time we hold the stir bar stationary and rotate the reaction flask instead?

Joshua Mcbee @jkmcbee.bsky.social · Aug 15

We don’t know what the risk of this modification is but we tested Ozempic as well and it was well within the guidelines of manufacturing peptide drugs.

Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what
You are going to get.

www.linkedin.com/posts/joshua...

If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks. | Josh McBee, M.S., Ph.D.

If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks. Recently we demonstrated a rapid LCMS assay using ...

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Joshua Mcbee @jkmcbee.bsky.social · Aug 15

Semaglutide as well. With the explosion of compounding GLP-1s we wanted to see if improper handling would create this modification. We “obtained” a syringe of compounded Semaglutide and sure enough the modification shows up at about 1.5% relative to the FLP which exceeds FDA guidelines.

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Joshua Mcbee @jkmcbee.bsky.social · Aug 15

Was sensitive to formaldehyde and could cyclize and this was noticed with interaction to certain excipients. We developed a quick assay for monitoring this modification. But we wanted to see if Semaglutide was sensitive to this modification too. Sure enough, exposure to formaldehyde modified

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Joshua Mcbee @jkmcbee.bsky.social · Aug 15

Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..

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Joshua Mcbee @jkmcbee.bsky.social · Jul 14

Is the report $2500?

Joshua Mcbee @jkmcbee.bsky.social · Jul 9

Perhaps a bit too obscure…

The Dune

“Oh hai Duncan!”

Joshua Mcbee @jkmcbee.bsky.social · Jun 20

Delaware pickleball is vicious man.

Joshua Mcbee @jkmcbee.bsky.social · Jun 6

That’s a big field.

Joshua Mcbee @jkmcbee.bsky.social · Jun 1

Dinner at Locust Point Steamers in Baltimore prior to #ASMS2025. Highly recommended for any seafood lovers coming to the conference!

Joshua Mcbee @jkmcbee.bsky.social · May 28

“The gorillas will freeze to death in the winter!”

Joshua Mcbee @jkmcbee.bsky.social · May 27

I feel like time of flight is a valid approach here. Maybe a bunch of trampolines for multi reflectron.

Joshua Mcbee @jkmcbee.bsky.social · May 21

The progress in drugs for treating cardiovascular disease over the last 5 years alone is remarkable. Drugs like Repatha and Leqvio virtually halt plaque deposition. The current guidelines for someone with CVD are to have your LDL-C below your HDL.