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JMCC Plus @jmccplus.bsky.social · 5d

Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

sciencedirect.com/science/arti...

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner

Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Sep 8

New work out in the from @ox.ac.uk looks into developing sex-specific human ventricular #electromechanical multiscale models. Given the importance of #biologicalsex in #CardiovascularHealth this could be a very important tool!

sciencedirect.com/science/arti...

#CardioSky

Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation

Women are under-represented in cardiovascular research, leading to poorer outcomes. Investigating sex-differences in electromechanical function is ess…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Aug 12

🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations.
Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models.
🔗 www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · Aug 8

12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs.
Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death.

www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · Aug 7

New paper out in our September issue from
Bass-Stringer and colleagues @bakerresearchau.bsky.social
looking at PI3K.

Exploring a new #genetherapy to improve heart function in mice and sheep.

sciencedirect.com/science/arti...

#CardioSky

Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart

Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Aug 6

Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research.

www.sciencedirect.com/science/arti...

JMCC Plus @jmccplus.bsky.social · Jul 31

📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy.
It outperformed conventional biomarkers like urinary ACR and NT-proBNP.
#CardioRenal #Biomarkers

www.sciencedirect.com/science/arti...

JMCC Plus @jmccplus.bsky.social · Jul 29

Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease.

Read more here! www.sciencedirect.com/science/arti...

JMCC Plus @jmccplus.bsky.social · Jun 29

New work just out from Fowler et al, invesigated the role of subthreshold #DADs on arrhythmia generation in #CPVT!

Congrats to the Authors!

sciencedirect.com/science/arti...

#CardioSky

Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associat…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Jun 26

NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research

www.sciencedirect.com/journal/jour...

JMCC Plus @jmccplus.bsky.social · Jun 23

New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles

Read more here! www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · Jun 20

Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus

JMCC Plus @jmccplus.bsky.social · Jun 16

Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types .
www.sciencedirect.com/science/arti...
‪@upenn.edu @temple.edu‬

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JMCC Plus @jmccplus.bsky.social · Jun 11

New #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors.

Want to know more?

www.sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · May 30

Looking for some weekend reading?

We recently published some work from Chambers et al. looking at the effect of an #SGLT2i on #mitochondrial function from non-diabetic mice with #Cardiomyopathy

Accompanied by a very nice editorial!

sciencedirect.com/science/arti...

SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice

Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. Alt…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · May 19

Are you looking for a new model of arrhythmia?
Maybe performance horses are the answer!
Great work just out from Avison et al!

www.sciencedirect.com/science/arti...

Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death

This paper reviews the myocardial substrate of horses relative to that of humans and discusses the utility of performance horses as a model of exercis…

www.sciencedirect.com

JMCC Plus @jmccplus.bsky.social · May 12

The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social

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JMCC Plus @jmccplus.bsky.social · May 12

The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees.
@ishr-aus.bsky.social

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JMCC Plus @jmccplus.bsky.social · May 9

Looking for some weekend reading or on your way to the
ISHR meeting in Japan?

Check out the recent work from Alican Guran,
@k8weeks.bsky.social et al. investigating the role of B56α as a mediator of cardiac responses to β-AR stimulation!

sciencedirect.com/science/arti...

PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling

B56α is a protein phosphatase 2 A (PP2A) regulatory subunit which modulates the heart's inotropic response to acute β-adrenergic receptor (β-AR) stimu…

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Mar 31

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model.

Read more: www.sciencedirect.com/science/arti...

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JMCC Plus @jmccplus.bsky.social · Mar 21

New Paper Alert!

New work just published investigated the differences in the #electrophysiology of the left and right stellate ganglia

What repercussions may this have for #Arrhythmia generation?

Congrats to the Authors and thanks to the Reviewers!

sciencedirect.com/science/arti...

#CardioSky

Electrophysiological comparison of left versus right stellate ganglia neurons

The stellate ganglia of the peripheral autonomic nervous system innervate the heart and continuously fine-tune cardiac function to meet physiological …

sciencedirect.com

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JMCC Plus @jmccplus.bsky.social · Feb 12

Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡
📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online

Hear from three leading experts as they dive into cutting-edge research & innovations.
🔗 Register now: https://buff.ly/4aWIbv1

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JMCC Plus @jmccplus.bsky.social · Feb 3

New research by Grazide and colleagues has revealed a novel biomarker for myocardial infarction risk. Rubicon, a negative regulator of autophagy, could aid in the early detection of individuals at high risk for MI
Read more here: https://buff.ly/3WyWO1i

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JMCC Plus @jmccplus.bsky.social · Jan 30

We are delighted to share that JMCC Plus is now officially indexed in PubMed Central (PMC)! Well done to all the editorial team, particularly our EiC @davorpavlovic.bsky.social and deputy @gundrylab.bsky.social 🎉

buff.ly

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JMCC Plus @jmccplus.bsky.social · Jan 20

Can we predict survival after #CardiogenicShock?

New research from researchers at Helsinki University and the Luxembourg Institute of Health show that a particular miRNA (miR-20b-5p) is associated with survival in cardiogenic shock!

#CardioSky

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock

Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adv…

sciencedirect.com

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