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Journal of Neuroimmunology

@jnijournal.bsky.social

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Official Journal of Neuroimmunology News Twitter. Latest articles on Immune & Brain interface research. Fellow @JNI_Journal for latest research news

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Journal of Neuroimmunology @jnijournal.bsky.social · 1d

Hypoglycorrhachia shapes the landscape of encephalitis. Low CSF/serum glucose flags infectious causes, while its absence points to autoimmune disease with higher ICU burden. #NeuroID #Encephalitis #Neuroimmunology

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www.jni-journal.com/article/S016...

The role of hypoglycorrhachia as a cerebrospinal fluid to serum glucose ratio in adults with encephalitis

We aimed to determine the clinical and prognostic significance of hypoglycorrhachia in adults with encephalitis.

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Journal of Neuroimmunology @jnijournal.bsky.social · 9d

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS

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www.jni-journal.com/article/S016...

Neurotoxicity associated with chimeric antigen receptor T-cell therapy

Chimeric antigen receptor T cell (CAR-T) therapy involves reengineering patient-derived or donor-derived T cells to express a synthetic CAR that can recognise specific cell-surface antigens, independe...

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Reposted by Journal of Neuroimmunology

SfN Journals @sfnjournals.bsky.social · 14d

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Journal of Neuroimmunology @jnijournal.bsky.social · 15d

Join us at #ISNI international congress 5-8 October in Chiba, Japan.
We are supporting the young investigator session.

Journal of Neuroimmunology @jnijournal.bsky.social · Sep 7

Beyond the brain: Our review explores how peripheral monocyte-derived macrophages (MDMs) shape Alzheimer’s disease pathogenesis—revealing new therapeutic opportunities outside the blood-brain barrier. 🧠🧬 #Alzheimers #Neuroimmunology

Check out the review below 👇

www.jni-journal.com/article/S016...

The immune response within Alzheimer's disease: from the lense of peripheral monocyte-derived macrophages

Alzheimer's disease (AD) is the most significant form of dementia characterized by neurodegeneration and higher-order cognitive decline affecting over 6.9 million Americans age 65 and older. Emerging ...

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Journal of Neuroimmunology @jnijournal.bsky.social · Sep 2

First reported case of AQP4+ NMOSD after golimumab for ulcerative colitis, presenting with intractable hiccups (Area Postrema Syndrome). Managed with plasmapheresis + rituximab, partial improvement.

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www.jni-journal.com/article/S016...

When gut and nerves collide: A case of Neuromyelitis Optica Spectrum disorder after golimumab for ulcerative colitis

Anti-TNF alpha agents, such as golimumab, are effective treatment options for moderate to severe inflammatory bowel disease. However, demyelinating syndromes have been reported as rare adverse events....

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Journal of Neuroimmunology @jnijournal.bsky.social · Aug 31

CAR-T therapy is eevolutionizing cancer care, but ICANS & new neurotoxicities remain major hurdles—biomarkers & targeted treatments are urgently needed. #CART #Oncology #Neurotoxicity #ICANS

Check out the paper 👇

www.jni-journal.com/article/S016...

Neurotoxicity associated with chimeric antigen receptor T-cell therapy

Chimeric antigen receptor T cell (CAR-T) therapy involves reengineering patient-derived or donor-derived T cells to express a synthetic CAR that can recognise specific cell-surface antigens, independe...

www.jni-journal.com

Journal of Neuroimmunology @jnijournal.bsky.social · Aug 15

Autoimmune nodopathies mimic seronegative GBS or CIDP but have distinct biology and treatment response — often failing IVIg or steroids, yet improving with anti-CD20 therapy.
Early recognition can be life-changing.
#Neurology #RareDisease

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www.jni-journal.com/article/S016...

The immunology and neuropathology of the autoimmune nodopathies

The autoimmune nodopthies have recently emerged as a discrete subtype of inflammatory neuropathy. They are characterised by the presence of IgG class autoantibodies directed against structural compone...

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Journal of Neuroimmunology @jnijournal.bsky.social · Aug 4

We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized.
#CallForPaper

Journal of Neuroimmunology | Early career investigators in Neuroimmunology | ScienceDirect.com by Elsevier

Historically, many established investigators in the field of neuroimmunology published early work from their laboratories in the Journal of Neuroimmunology. Our mission is to bring important work in t...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jul 17

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling

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www.jni-journal.com/article/S016...

Rapid one-step protocol for exploring immune cells in cerebrospinal fluid

Flow cytometry analysis of the cerebrospinal fluid's immune cell subset profiles can be used to help in the diagnosis and prognosis of nervous system pathologies. However, the cells need to be analyze...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jul 6

Thinking about how seasons and environment affect myasthenia gravis. UV rays, humidity, and summer activity might play bigger roles than we know. More research ahead! #MyastheniaGravis #Science

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www.jni-journal.com/article/S016...

Reflections on the influence of seasonal and environmental factors in myasthenia gravis

After carefully reading the short communication titled “Seasonal variation in myasthenia gravis incidence (Falso et al., 2025)” by Falso et al., published in the Journal of Neuroimmunology, I was intr...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 18

Inflammation meets depression: Blocking hippocampal necroptosis eases depressive-like behavior in mice. Targeting RIPK3–MLKL could be a game-changer in depression. #Neuroscience #MentalHealth #DepressionResearch

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www.jni-journal.com/article/S016...

RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation

Neuroinflammation is a critical pathophysiological mechanism of depression. But the sources and processes involved remain unclear. Recent reports suggest that necroptosis with pro-inflammatory propert...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 16

TGFB1 is elevated in MS and correlates with IFNB1, which varies by disease phase but not IFN-β therapy.

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www.jni-journal.com/article/S016...

Association of TGFB1 and IFNB1 expression levels in peripheral blood mononuclear cells with multiple sclerosis with respect to proximal rs1800469 and rs2275888 eQTLs

Multiple sclerosis (MS) is a central nervous system inflammatory disorder with evidence of peripheral immune system dysregulation. Complex signaling interaction of immune cytokines transforming growth...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 12

Stiff Person Syndrome Spectrum Disorders are under-recognized, immune-mediated conditions with diverse presentations—advances in treatment and understanding offer new hope!

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www.jni-journal.com/article/S016...

Stiff person syndrome spectrum disorders; more than meets the eye

Stiff person syndrome spectrum disorders (SPSD) are a group of rare neuroimmunological disorders that often include painful spasms and rigidity. However, patients have highly heterogeneous signs and s...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 12

Don't miss this new case report on Neuro-Behçet's disease featured below 👇

www.jni-journal.com/article/S016...

Inflammatory cerebral pseudotumour as a rare manifestation of neuro-Behçet's disease: A case report and literature review

Neurological involvement in Behçet's syndrome is rare but is associated with significant morbidity and mortality. Two subtypes of neuro-Behçet's disease (NBD) are typically described: parenchymal and ...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 2

High IL-10 and IL-12 serum levels in serum of Myasthenia Gravis patients could be used as potential biomarkers.

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www.jni-journal.com/article/S016...

Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis

IL-10 and IL-12 family cytokines play important roles in various immunological diseases. This study identified a relationship between IL-10 and IL-12 family cytokines and the pathogenesis of myastheni...

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Journal of Neuroimmunology @jnijournal.bsky.social · Jun 2

CD4+ CD25+ T regs activated with MBP and rIL-2 ameliorate EAE and may serve as therapeutic agent for autoimmunity.

Check out the paper below 👇:

www.jni-journal.com/article/S016...

Autoantigen and IL-2 activated CD4+CD25+T regulatory cells are induced to express CD8 and are autoantigen specific in inhibiting experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin basic protein (MBP) is a self-limiting disease model of multiple sclerosis. CD4+CD25+Foxp3+T cells play a role in li...

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Journal of Neuroimmunology @jnijournal.bsky.social · May 14

Brucella neurotype induces CNS damage via the QUIN/NMDAR/Ca²⁺/CaMKII/ROS pathway, highlighting a promising therapeutic target
Check the paper below ⬇️

www.jni-journal.com/article/S016...

Activation of NMDAR/Ca2+/CaKMII/ROS pathway by Brucella induced neuronal cell apoptosis

Neurobrucellosis is an inflammatory disease of the central nervous system caused by brucellosis and is the most serious form of brucellosis. However, the pathogenesis of this disease is not well under...

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Journal of Neuroimmunology @jnijournal.bsky.social · Apr 16

C-hype lectin protein derived from Toxocara canis larvae decreases disability scores in EAE, potentially through CD4+CD25+Foxp3+ Tregs

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www.jni-journal.com/article/S016...

Toxocara canis-originated recombinant C-type lectin improves the disability scores of experimental autoimmune encephalomyelitis in murine in vivo models

The recombinant C-type lectin protein (r-CTL) derived from Toxocara canis larvae is thought to play a role in promoting regulatory T cell-dominant immune responses in toxocariasis. This study aimed to...

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Journal of Neuroimmunology @jnijournal.bsky.social · Apr 7

A case report study: Thalidomide treatment is associated with RRMS

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www.jni-journal.com/article/S016...

Relapsing-remitting multiple sclerosis as a potential consequence of thalidomide treatment: A case report

We present the first reported case of central nervous system (CNS) demyelination associated with thalidomide. A 29-year-old female with a history of prurigo nodularis was prescribed thalidomide after ...

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Journal of Neuroimmunology @jnijournal.bsky.social · Apr 4

The interplay between Rasmussen Encephalitis (RE) and localized Scleroderma (LS), a case report and literature review .

Check out this newly published paper 👇

www.jni-journal.com/article/S016...

Rasmussen encephalitis and localized scleroderma of the lower limb: Another piece of the puzzle. A case-report and literature review with individual participant data

The co-occurrence of Rasmussen encephalitis (RE) and localized scleroderma (LS) is rare and poorly known. We describe the unique case of a 23-year-old patient with late-onset RE of the right hemispher...

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Journal of Neuroimmunology @jnijournal.bsky.social · Mar 22

Interplay between peripheral & central nervous system inflammatory processes during major depressive disorder (MDD)

Check out this new review 👇

www.jni-journal.com/article/S016...

Peripheral and central inflammation in depression: How large is the gap and can we bridge it with PET neuroimaging and neural-derived extracellular vesicles?

Major depressive disorder (MDD) presents as a multifaceted syndrome with complex pathophysiology and variable treatment responses, posing significant challenges in clinical management. Neuroinflammati...

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Journal of Neuroimmunology @jnijournal.bsky.social · Mar 19

Toxoplasma Gondii infection is linked with Astrocytic distinction, which could be linked to the progression of Schizophrenia

Check this paper released today 👇 www.jni-journal.com/article/S016...

Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction

Obligate intracellular pathogens such as the protozoan Toxoplasma gondii exploit host cell mechanisms to facilitate their survival and replication. While T. gondii can infect any nucleated mammalian c...

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Journal of Neuroimmunology @jnijournal.bsky.social · Mar 8

Resistance and endurance training differentially influence neuroinflammation during progressive vascular cognitive impairment.

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www.jni-journal.com/article/S016...

Scientific status analysis of exercise benefits for vascular cognitive impairment: Evidence of neuroinflammation

Vascular cognitive impairment (VCI) is a syndrome characterized by cognitive decline resulting from insufficient perfusion to the entire brain or specific brain regions. The lack of a clear understand...

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Journal of Neuroimmunology @jnijournal.bsky.social · Feb 27

Remission from methamphetamine dependence is characterized by neuropsychiatric impairments, fatigue, sleep and memory perturbations as well as CD4+ and B cell losses.

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www.jni-journal.com/article/S016...

Fatigue, disturbed sleep, persistent memory problems, and reduced CD4+ T cell and B cell percentages in adults with a history of methamphetamine dependence

Methamphetamine (MA) dependence is associated with immunotoxicity and high rates of neuropsychiatric impairments that persist into remission. Although there are currently no FDA-approved pharmacothera...

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