Stop and Think
@johnmandrola.skystack.xyz
A skeptical but not cynical view of scientific evidence
This is an automated Substack Account of https://johnmandrola.substack.com
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This is an automated Substack Account of https://johnmandrola.substack.com
Discover more/Create at: @skystack.xyz
Some Year End Things and A Pro-Tip
Some Year End Things and A Pro-Tip
johnmandrola.substack.com
January 2, 2026 at 7:47 PM
Some Year End Things and A Pro-Tip
Do Pictures Change Patient Behaviors? • The Limits of Fear in Medicine
Do Pictures Change Patient Behaviors?
The Limits of Fear in Medicine
jamesstein18.substack.com
December 11, 2025 at 4:47 PM
Do Pictures Change Patient Behaviors? • The Limits of Fear in Medicine
What I believe in Medicine
What I believe in Medicine
johnmandrola.substack.com
December 11, 2025 at 4:47 PM
What I believe in Medicine
A Fall Update of My Work Outside of the EP Lab
A Fall Update of My Work Outside of the EP Lab
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
A Fall Update of My Work Outside of the EP Lab
Medical evidence should not be too technical for doctors
Medical evidence should not be too technical for doctors
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Medical evidence should not be too technical for doctors
Prasad Being Forced Out of FDA is a Sad Day for Evidence-Based Medicine
Prasad Being Forced Out of FDA is a Sad Day for Evidence-Based Medicine
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Prasad Being Forced Out of FDA is a Sad Day for Evidence-Based Medicine
This Week in Cardiology Podcast is Fixed • I did a deep dive into cardiac imaging, focusing on the use of CTA for the diagnosis of coronary artery disease. I think the anatomic imaging test is leading us astray.
This Week in Cardiology Podcast is Fixed
I did a deep dive into cardiac imaging, focusing on the use of CTA for the diagnosis of coronary artery disease. I think the anatomic imaging test is leading us astray.
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
This Week in Cardiology Podcast is Fixed • I did a deep dive into cardiac imaging, focusing on the use of CTA for the diagnosis of coronary artery disease. I think the anatomic imaging test is leading us astray.
Restoring Gold Standard Science is Far More than Stopping Fraud • Some brief thoughts on the call for Gold Standard Science
Restoring Gold Standard Science is Far More than Stopping Fraud
Some brief thoughts on the call for Gold Standard Science
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Restoring Gold Standard Science is Far More than Stopping Fraud • Some brief thoughts on the call for Gold Standard Science
Things I have worked on in the last month
Things I have worked on in the last month
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Things I have worked on in the last month
Trials That Attempt to Expand Treatment Indications but Do Not Increase Knowledge • My latest column is up over at theheart.org | Medscape Cardiology
Trials That Attempt to Expand Treatment Indications but Do Not Increase Knowledge
My latest column is up over at theheart.org | Medscape Cardiology
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Trials That Attempt to Expand Treatment Indications but Do Not Increase Knowledge • My latest column is up over at theheart.org | Medscape Cardiology
Big Weekend Coming Up in Cardiology
Big Weekend Coming Up in Cardiology
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Big Weekend Coming Up in Cardiology
A New Proposal for AF studies: Jettison the "Blanking Period" • Since the beginning of AF ablation 20 years ago, studies have used a 90-day blanking period after the procedure where AF episodes do not count. It is not right.
A New Proposal for AF studies: Jettison the "Blanking Period"
Since the beginning of AF ablation 20 years ago, studies have used a 90-day blanking period after the procedure where AF episodes do not count. It is not right.
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
A New Proposal for AF studies: Jettison the "Blanking Period" • Since the beginning of AF ablation 20 years ago, studies have used a 90-day blanking period after the procedure where AF episodes do not count. It is not right.
Thoughts on the MAHA Movement
Thoughts on the MAHA Movement
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Thoughts on the MAHA Movement
Electrophysiology is on the brink of a possible disaster • A flawed study with positive results has sparked enthusiasm for implantation of left atrial appendage devices during AF ablation. it is a potential disaster.
Electrophysiology is on the brink of a possible disaster
A flawed study with positive results has sparked enthusiasm for implantation of left atrial appendage devices during AF ablation. it is a potential disaster.
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Electrophysiology is on the brink of a possible disaster • A flawed study with positive results has sparked enthusiasm for implantation of left atrial appendage devices during AF ablation. it is a potential disaster.
Links to My Recent Writing and Speaking • I have been busy writing. Here is a summary and links.
Links to My Recent Writing and Speaking
I have been busy writing. Here is a summary and links.
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
Links to My Recent Writing and Speaking • I have been busy writing. Here is a summary and links.
I Might Have Been Wrong About Pulsed Field Ablation for Atrial Fibrillation • Emphasis on "might"
I Might Have Been Wrong About Pulsed Field Ablation for Atrial Fibrillation
Emphasis on "might"
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
I Might Have Been Wrong About Pulsed Field Ablation for Atrial Fibrillation • Emphasis on "might"
How do Dubious Norms Get Established? • A look at an old trial might explain how the norms of cardiology came to be despite a dubious evidence base
How do Dubious Norms Get Established?
A look at an old trial might explain how the norms of cardiology came to be despite a dubious evidence base
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
How do Dubious Norms Get Established? • A look at an old trial might explain how the norms of cardiology came to be despite a dubious evidence base
The Cardiology Seminal Trial's series is well underway • Please do read the seminal trials. You will learn stuff that you likely did not know. Stuff that does not make the colored boxes in guidelines.
The Cardiology Seminal Trial's series is well underway
Please do read the seminal trials. You will learn stuff that you likely did not know. Stuff that does not make the colored boxes in guidelines.
johnmandrola.substack.com
November 24, 2025 at 12:50 PM
The Cardiology Seminal Trial's series is well underway • Please do read the seminal trials. You will learn stuff that you likely did not know. Stuff that does not make the colored boxes in guidelines.