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jonathanbohlen.bsky.social
Jonathan Bohlen
@jonathanbohlen.bsky.social
320 followers 460 following 46 posts
Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students! Dad in Science, He/His
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Nov 13
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc
@casanova_lab, published in @jclinical-invest.bsky.social
If you’re interested in the causes of autoinflammation, then this one is for you: t.co/uhVDdzqyx2
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Reposted by Jonathan Bohlen
rupress.org
Rockefeller University Press @rupress.org · 8d
New in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/...

#Staphylococcus #Ubiquitin
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · 13d
It was a great pleasure to join the symposium, meet with great scientists and learn new things! Congrats again for the award!
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Reposted by Jonathan Bohlen
deevybee.bsky.social
Dorothy Bishop @deevybee.bsky.social · Aug 24
Huge variability documented in how publishers respond when informed about a problematic body of work by a research group. www.jclinepi.com/article/S089...
#publishers #retractions
Bar chart showing % of articles retracted, with expression of concern, or no action from different publishers. 100% no action from Elsevier and Wolters Kluwer; 100% retraction from Taylor and Francis.
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Reposted by Jonathan Bohlen
casanovalab.bsky.social
Casanova Lab @casanovalab.bsky.social · Aug 19
A MUST-READ Review on Penetrance of Human Monogenic Inborn Errors (of Immunity, or not):

Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel | Journal of Human Immunity | Rockefeller University Press
Incomplete penetrance in genetic disorders can be influenced by genetic variant quality, genetic and epigenetic modification, environment, and mosaicism.
rupress.org
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Reposted by Jonathan Bohlen
bogunoviclab.bsky.social
Bogunovic Lab @bogunoviclab.bsky.social · Aug 13
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo
A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.
www.science.org
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jul 26
Excited to participate in this symposium!
casanovalab.bsky.social
Casanova Lab @casanovalab.bsky.social · Jul 25
1/ Join us on 24 Sept 2025 at the @institutimagine.bsky.social in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at:
my.weezevent.com/novo-nordisk...
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jul 4
Very nice review on genetic insights to B cell development: rupress.org/jhi/article/... by @alneehus.bsky.social and @bloodgenes.bsky.social
Human genetic influences on early B cell development | Journal of Human Immunity | Rockefeller University Press
This review explores how genetic variation impacts early B cell development, highlighting key genes and pathways involved in lineage commitment, V(D)J reco
rupress.org
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Reposted by Jonathan Bohlen
genecenter-lmu.bsky.social
Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · Jul 1
🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex...
@v-hornung.bsky.social @m-berouti.bsky.social
Innate immune system: How modified RNA tricks the immune system
Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.
www.lmu.de
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jun 28
Whaaaat!=!=!=
Reposted by Jonathan Bohlen
rando.insalubrio.us
Brandon Moore, PhD @rando.insalubrio.us · Jun 27
@nbellono.bsky.social and colleagues observed that Elysia sea slugs steal chloroplasts from algae and store them in specialized organelles called kleptosomes. During times of starvation, this allows them to photosynthesize in support of their energy needs! 🧪

www.cell.com/cell/abstrac...
Graphical abstract of the linked paper. Sea slugs retain and store foreign chloroplasts in kleptosome organelles (top). Kleptosomes use luminal ATP-sensing ion channels to support photosynthesis (bottom left). Kleptosomes digest chloroplasts during prolonged starvation (bottom center). Slugs and corals use convergent mechanisms of endosymbiosis (bottom right).
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Reposted by Jonathan Bohlen
petterbrodin.bsky.social
Petter Brodin @petterbrodin.bsky.social · Jun 25
No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases
Click on the article title to read more.
onlinelibrary.wiley.com
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jun 17
We are looking for motivated Master Students who are interested to start an internship or thesis in the fall. The project will focus on molecular biology of mRNA translation and is a great opportunity to master some staple methods. Please get in touch @genecenter-lmu.bsky.social tinyurl.com/3f3kwmja
Bohlen Lab - mRNA Translation in Human Immunity - Gene Center Munich - LMU Munich
www.genzentrum.uni-muenchen.de
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jun 13
Outstanding poster!!
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · Jun 2
Congrats to the authors! Amazing method!
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 30
Congrats! This is super cool.
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 23
Congrats!! Well deserved!
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 21
Yes, totally agree! What's your favorite? I'd probably say Tbet :)
jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 21
Comprehensive and convincing report of a new IEI, with just a single patient! Congrats Stuart and the team. Stellar!
turveylab.bsky.social
Turvey Lab @turveylab.bsky.social · May 20
📢📢Published today in @jem.org 📢📢
New human inborn error of immunity.

We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.

rupress.org/jem/article/...

@ubcmedicine.bsky.social @bcchresearch.bsky.social
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 17
Wow, very cool and unexpected findings!
kurianlab.bsky.social
Kurianlab @kurianlab.bsky.social · May 17
www.cell.com/molecular-ce...
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency
Prkra serves as a primary dsRNA sensor in pluripotent cells, restricting RNA virus replication. By dimerizing through dsRBD3, it sequesters eIF2 complexes from the translation machinery and compensate...
www.cell.com
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 17
Thank you, that's very clear! Congrats again :)
jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 16
Fascinating!
rupress.org
Rockefeller University Press @rupress.org · May 16
New in @jem.org - Antunes et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. They show that mice with this mutation are hyposensitive to acute and chronic pain, and uncover the underlying mechanism. rupress.org/jem/article/...
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 16
And of course congrats for the terrific work!!
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 16
Hi Huiqing,
as an occasional sequencer of tRNAs I would be really grateful for a short thread on this paper! I'd be especially curious about where you see the advantages / disadvantages of this compared to other state-of-the-art methods like mim-tRNA-seq, which also identifies many modifications THX
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Reposted by Jonathan Bohlen
cjcarnie.bsky.social
Chris Carnie @cjcarnie.bsky.social · May 14
A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!

karriere.klinikum.uni-heidelberg.de/index.php?ac...
PhD position in the biology and treatment of Osteosarcoma (m/f/d)
Pflichtfelder sind mit einem (*) markiert.
karriere.klinikum.uni-heidelberg.de
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jonathanbohlen.bsky.social
Jonathan Bohlen @jonathanbohlen.bsky.social · May 8
Excited to welcome Evan and exchange ideas!
genecenter-lmu.bsky.social
Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · May 8
We're happy to welcome Evangelos Karousis next Monday! 🎉
He’ll be talking about “Decoding viral secrets using cell-free translation” 🧬
📅 May 12 🕐 1:15 PM ➡️Lynen Lecture Hall
Don’t miss it! 🤗✨
@karousislab.bsky.social @jonathanbohlen.bsky.social
@unibe.ch
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