Kurianlab
@kurianlab.bsky.social
RNA biology of embryonic development and disease #heart #ribosome #translational_control #RBP #splicing @UK_Frankfurt Alum:@salkinstitute @UcSandiego
https://kurianlab.com/
https://kurianlab.com/
Pinned
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RBP2GO - Version 2.0
rbp2gov2.dkfz.de
November 27, 2025 at 4:49 AM
Reposted by Kurianlab
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
November 26, 2025 at 4:00 PM
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Reposted by Kurianlab
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Postdoc (m/f/d) in Endosymbiosis Research
karriere.hhu.de
November 25, 2025 at 11:21 AM
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
MERFISH+ by Quan Zhu and colleagues
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
MERFISH+, a large-scale, multi-omics spatial technology resolves the molecular holograms of the 3D human developing heart
Hybridization-based spatial transcriptomics technologies have advanced our ability to map cellular and subcellular organization in complex tissues. However, existing methods remain constrained in gene...
www.biorxiv.org
November 25, 2025 at 5:47 PM
MERFISH+ by Quan Zhu and colleagues
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
November 24, 2025 at 1:15 PM
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
GENOMIC IMPRINTING | Edge.org
www.edge.org
November 25, 2025 at 5:37 AM
www.biorxiv.org/content/10.1...
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
www.biorxiv.org
November 24, 2025 at 7:55 AM
www.biorxiv.org/content/10.1...
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Reposted by Kurianlab
Nice piece highlighting the innovative science at Firefly Bio, making ADCs with PROTAC-like drugs: degrader-antibody conjugates, or “DACs”, with better precision and tolerability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Editor’s pick: Firefly Bio - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Firefly Bio seeks to improve on antibody–drug conjugates and proteolysis-targeting...
www.nature.com
November 21, 2025 at 4:52 PM
Nice piece highlighting the innovative science at Firefly Bio, making ADCs with PROTAC-like drugs: degrader-antibody conjugates, or “DACs”, with better precision and tolerability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kurianlab
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
November 21, 2025 at 8:20 AM
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
Reposted by Kurianlab
Dear reviewer its not really helpful if you list all the good things about us but you still reject the grant because you don't like the workplan
November 20, 2025 at 11:43 AM
Dear reviewer its not really helpful if you list all the good things about us but you still reject the grant because you don't like the workplan
Reposted by Kurianlab
Wild to think that just a few months ago this administration was cracking down on universities for not doing enough to root out antisemitism www.washingtonpost.com/national-sec...
U.S. Coast Guard will no longer classify swastikas, nooses as hate symbols
The military service, which falls under the Department of Homeland Security, has drafted a new policy that classifies such items “potentially divisive.”
www.washingtonpost.com
November 20, 2025 at 7:41 PM
Wild to think that just a few months ago this administration was cracking down on universities for not doing enough to root out antisemitism www.washingtonpost.com/national-sec...
Reposted by Kurianlab
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
November 20, 2025 at 3:08 AM
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
Reposted by Kurianlab
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
www.biorxiv.org
November 20, 2025 at 7:08 AM
Aguably the most important work by my fav Pathology Professor: @akispapantonis.bsky.social
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Neue Methoden am Übergang von der Forschung in die Routinediagnostik - Die Pathologie
Background Pathology, traditionally focused on classification and diagnosis, is continuously evolving through new technologies. Advances in proteomics, epigenetics, tissue staining, and 3D imaging exp...
link.springer.com
November 19, 2025 at 4:12 PM
Aguably the most important work by my fav Pathology Professor: @akispapantonis.bsky.social
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Kurianlab
As the DEI Crackdown Escalates, Faculty Choose Between Silence and Resistance
While one professor says faculty are “pre-emptively censoring themselves” in response, others are defiant—while another is asking himself, “What would I be willing to lose my job for?” #HigherEd #EDUSky bit.ly/413XhLP
While one professor says faculty are “pre-emptively censoring themselves” in response, others are defiant—while another is asking himself, “What would I be willing to lose my job for?” #HigherEd #EDUSky bit.ly/413XhLP
Trump attacks DEI; faculty pick between silence, resistance
While one professor says faculty are “pre-emptively censoring themselves” in response, others are defiant—while another is asking himself, “What would I be willing to lose my job for?”
bit.ly
February 6, 2025 at 3:39 PM
As the DEI Crackdown Escalates, Faculty Choose Between Silence and Resistance
While one professor says faculty are “pre-emptively censoring themselves” in response, others are defiant—while another is asking himself, “What would I be willing to lose my job for?” #HigherEd #EDUSky bit.ly/413XhLP
While one professor says faculty are “pre-emptively censoring themselves” in response, others are defiant—while another is asking himself, “What would I be willing to lose my job for?” #HigherEd #EDUSky bit.ly/413XhLP
Reposted by Kurianlab
@psomagen, not here, on Ultima Genomics pricing for Short Read NGS sequencing on the UG100 instrument. Specs at bit.ly/ngsspecs
November 18, 2025 at 6:34 AM
@psomagen, not here, on Ultima Genomics pricing for Short Read NGS sequencing on the UG100 instrument. Specs at bit.ly/ngsspecs
Reposted by Kurianlab
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
November 17, 2025 at 11:28 AM
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
Reposted by Kurianlab
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by Kurianlab
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
bit.ly/4oHxUZp
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
bit.ly
November 15, 2025 at 8:17 PM
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
bit.ly/4oHxUZp