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jonbrudvig.bsky.social
Jon Brudvig
@jonbrudvig.bsky.social
23K followers 620 following 310 posts
Translating the Science of Health & Longevity USD Bio Professor, Drug Developer 📖 Longer content on LinkedIn: linkedin.com/in/jon-brudvig-phd-9b1830134 📰Sign up for my monthly Substack newsletter, Translation: jonbrudvig.substack.com
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Jon Brudvig @jonbrudvig.bsky.social · Apr 7
I just launched my new Substack, Translation. I'll use this space to break down the latest longevity research, infer trends across disparate studies, and to share real-world protocols and applications.

Please subscribe and join the conversation!

jonbrudvig.substack.com

#longevity #healthspan
A colorful semicircle, with text reading "Welcome to Translation. Speaking the language of longevity. The promise of longevity research won't be realized with a bang. It's already unfolding, quietly and gradually, in mouse studies and human clinical trials, buried in dense research articles and preprints. Jonbrudvig.substack.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · 14d
Very excited for my next full length Substack post, which will be a deep dive into thymic regeneration, complete with history, risks & benefits, and pharma protocols. In the meantime, here’s a teaser on the topic, shared earlier this year 🧪:

#Longevity #Aging
jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Mar 3
Did you know that your thymus hasn’t been fully functional since you were an infant?

Since that time, it has progressively “involuted”—shrunk and been mostly replaced by fat. Without it, you can’t mature new naïve T-cells. Most of the naïve T-cells you have today were actually produced decades ago.
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Jon Brudvig @jonbrudvig.bsky.social · 23d
Paul is a wonderful host and really shaped a great conversation! Check it out here: 🧪

podcasts.apple.com/au/podcast/u...
Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part One
Podcast Episode · The Paul Taylor Podcast | Expert in Hardiness and Mental Fitness · 05/09/2025 · 41m
podcasts.apple.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · 23d
In Part 1, we explore: 🧪

Why lysosomes are the forgotten organelle for longevity

How longevity interventions are discovered and what this means for their applications in humans.

How promising interventions SGLT2 inhibitors are already showing longevity promise in humans.
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · 23d
Recently, I sat down with Paul Taylor to discuss the intimate links between lysosomal health and aging. We touched on so many important topics in this one, with an overarching focus on practical, science-backed strategies for living a healthier life. 🧪

#Longevity
Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part One
Podcast Episode · The Paul Taylor Podcast | Expert in Hardiness and Mental Fitness · 05/09/2025 · 41m
podcasts.apple.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · 28d
David is building a fascinating resource: a curated database of personal “longevity stacks” from scientists, physicians, and health optimizers with very diverse backgrounds. 🧪

Check it out at
wellstackedlife.com
Wellstackedlife
wellstackedlife.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · 28d
Last week, I sat down with David Blackmore to walk through my personal #longevity strategy. He did an excellent job distilling our conversation into key takeaways, focusing on diet, exercise, and drugs/supplement approaches. 🧪
Lysosomes, Wine, and a Real-World Longevity Stack – Wellstackedlife
wellstackedlife.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 27
I'm looking forward to joining David and John Gildea tomorrow to record a new episode of the Mara Labs podcast! Stay tuned.
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 27
David Roberts and Mara Labs just posted a nice, concise article on the #microplastics health problem and #sulforaphane as a potential tool for liberating the particles from cells. 🧪

Definitely worth a read if you are looking for a quick intro.

mara-labs.com/blogs/journa...

#Longevity
Microplastics: A Growing Threat + A Promising Solution
Most people have heard that plastic pollution is choking the oceans. Fewer realize that plastic has also invaded our bodies, even reaching our brains and blood. Startling new research reveals that the...
mara-labs.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
Key sources 2: 🧪
📰 Lithium stabilizes cognitive impairment in AD:
pubmed.ncbi.nlm.nih.gov/22746245/
📰 Mechanistic insights in mice and observational data in humans:
www.nature.com/articles/s41...
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
Key sources 1: 🧪

📰 AD incidence with and without APOE4:
www.nature.com/articles/s41...
📰 Lithium in drinking water and AD prevalence:
jamanetwork.com/journals/jam...
pmc.ncbi.nlm.nih.gov/articles/PMC...
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
Discussed in detail in my latest Substack post. 🧪

jonbrudvig.substack.com/p/lithium-pr...
Lithium Prevents Alzheimer’s—Here’s How to Use It
Even as evidence builds, most experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake.
jonbrudvig.substack.com
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Jon Brudvig @jonbrudvig.bsky.social · Aug 21
Observational and interventional studies tell us that microdoses in the range of 0.02–0.3 mg/day are protective. That’s thousands of times lower than psychiatric doses, with a nearly zero risk of toxicity or side effects, and very inexpensive.

This is easily achieved with lithium supplements. 🧪
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Jon Brudvig @jonbrudvig.bsky.social · Aug 21
So, why aren't we using it? Experts are hesitating to recommend lithium until optimal doses are confirmed in large, definitive trials.

But in high-stakes scenarios like this, waiting for confirmatory evidence could mean missing the window for prevention. Acting now is wise. 🧪
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
🧠 Mechanisms: blocks tau phosphorylation, shifts amyloid processing, clears plaques. 🧪
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Jon Brudvig @jonbrudvig.bsky.social · Aug 21
💊 Supplementing with 0.3 mg/day slows cognitive decline in Alzheimer's patients. 🧪
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Jon Brudvig @jonbrudvig.bsky.social · Aug 21
🫗 Natural lithium in drinking water → 20%+ reduction in Alzheimer’s rates. 🧪
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Jon Brudvig @jonbrudvig.bsky.social · Aug 21
This is supported by robust observational data from many thousands of individuals, small interventional studies in Alzheimer’s patients, and a relatively robust understanding of mechanism. 🧪
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
If you live to 95, your risk of developing dementia is 42%. For APOE4 carriers, it’s as high as 59%.

A trace mineral, lithium, can lower that risk at extremely low doses. So potently, that it could even counteract the impact of the worst genetic and environmental risk factors. 🧪
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 21
Lithium prevents Alzheimer’s. Here’s how to use it. 🧪

jonbrudvig.substack.com/p/lithium-pr...

#Alzheimer's #Longevity #Prevention
Lithium Prevents Alzheimer’s—Here’s How to Use It
Even as evidence builds, most experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake.
jonbrudvig.substack.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 16
Huge disappointment is an understatement.

We have massive incentives to prioritize the health of ourselves and the planet over economic growth, but again and again we fail to do so. Devastating.
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Jon Brudvig @jonbrudvig.bsky.social · Aug 14
Even as evidence builds, many experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake. 🧪

My latest post breaks down the science and gives practical recommendations for implementation.

jonbrudvig.substack.com/p/lithium-pr...

#Alzheimer's #Longevity #BrainHealth
Lithium Prevents Alzheimer’s—Here’s How to Use It
Even as evidence builds, most experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake.
jonbrudvig.substack.com
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 13
Key Sources 3: 🧪
📰 Metformin blunts exercise adaptations:
pmc.ncbi.nlm.nih.gov/articles/PMC...

📰 The case against metformin in healthy individuals:
drglorioso.substack.com/p/should-you...
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Jon Brudvig @jonbrudvig.bsky.social · Aug 13
Key Sources 2: 🧪

📰 Low dose metformin improves healthspan and lifespan in mice: pmc.ncbi.nlm.nih.gov/articles/PMC...

📰 Metformin decreases PD risk only when used at low doses: pmc.ncbi.nlm.nih.gov/articles/PMC...

📰 Metformin blunts exercise adaptations:
pubmed.ncbi.nlm.nih.gov/31557380/
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jonbrudvig.bsky.social
Jon Brudvig @jonbrudvig.bsky.social · Aug 13
Key Sources: 🧪
📰 Metformin MOA: www.nature.com/articles/s41...

📰 Metformin promotes metabolic health, prevents diabetes, and promotes modest, durable weight loss: pubmed.ncbi.nlm.nih.gov/11832527/

📰 Metformin reduces systemic inflammation: pubmed.ncbi.nlm.nih.gov/33412927/
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Jon Brudvig @jonbrudvig.bsky.social · Aug 13
We don’t yet have RCTs that can confirm the benefits in healthy individuals, and we likely won’t for quite some time. But with current evidence pointing towards benefits across many aging organs, one must also consider the risks of waiting for that evidence to exist.
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