Jordi Xiol
@jordixiol.bsky.social
Science, history, and drug development | https://vineyardbooks.substack.com/
You are not rewriting the genetic code, John Evans, you are rewriting the genetic sequence. The genetic code has been the same since life can call itself life
$BEAM
$BEAM
March 10, 2025 at 11:54 AM
You are not rewriting the genetic code, John Evans, you are rewriting the genetic sequence. The genetic code has been the same since life can call itself life
$BEAM
$BEAM
An overwhelming majority are listed in the US. The time is right for Europe to move towards a common listing
February 19, 2025 at 11:12 AM
An overwhelming majority are listed in the US. The time is right for Europe to move towards a common listing
$AZN key 2025 catalysts. AVANZAR trial (Dato-Dxd + durvalumab + chemo) in first-line lung cancer one to watch
The combo of ADC + checkpoint inhibitor worked remarkably well in bladder cancer, will this become a broader concept in oncology treatment?
The combo of ADC + checkpoint inhibitor worked remarkably well in bladder cancer, will this become a broader concept in oncology treatment?
February 6, 2025 at 12:09 PM
$AZN key 2025 catalysts. AVANZAR trial (Dato-Dxd + durvalumab + chemo) in first-line lung cancer one to watch
The combo of ADC + checkpoint inhibitor worked remarkably well in bladder cancer, will this become a broader concept in oncology treatment?
The combo of ADC + checkpoint inhibitor worked remarkably well in bladder cancer, will this become a broader concept in oncology treatment?
$NVS cardiovascular franchise showing its muscle: Both Entresto and Leqvio were characterized as very poor launches, now they are both major growth drivers
www.novartis.com/sites/novart...
www.novartis.com/sites/novart...
January 31, 2025 at 2:09 PM
$NVS cardiovascular franchise showing its muscle: Both Entresto and Leqvio were characterized as very poor launches, now they are both major growth drivers
www.novartis.com/sites/novart...
www.novartis.com/sites/novart...
Daraxonrasib looks a bit more efficacious but zoldonrasib's safety profile is remarkable. MTD wasn't reached but it seems to be maxing out on exposure
#ASCOGI
#ASCOGI
January 26, 2025 at 2:33 PM
Daraxonrasib looks a bit more efficacious but zoldonrasib's safety profile is remarkable. MTD wasn't reached but it seems to be maxing out on exposure
#ASCOGI
#ASCOGI
Efficacy of pan-RAS and KRAS G12D inhibitors from $RVMD in 2L PDAC: 36% and 30% ORR for daraxonrasib and zoldonrasib, respectively
#ASCOGI
#ASCOGI
January 26, 2025 at 2:27 PM
Efficacy of pan-RAS and KRAS G12D inhibitors from $RVMD in 2L PDAC: 36% and 30% ORR for daraxonrasib and zoldonrasib, respectively
#ASCOGI
#ASCOGI
The founder of Christianity, a distinct religion from Judaism centered around the divinity of Jesus, was Paul the Apostle, not Jesus himself.
Hyam Maccoby is the author that best encapsulates this notion
Hyam Maccoby is the author that best encapsulates this notion
December 29, 2024 at 9:10 PM
The founder of Christianity, a distinct religion from Judaism centered around the divinity of Jesus, was Paul the Apostle, not Jesus himself.
Hyam Maccoby is the author that best encapsulates this notion
Hyam Maccoby is the author that best encapsulates this notion
The Krebs cycle is not the most important metabolic pathway in biology. The Krebs cycle IS biology
December 15, 2024 at 3:28 PM
The Krebs cycle is not the most important metabolic pathway in biology. The Krebs cycle IS biology
Gukesh Dommaraju just became the youngest ever world chess champion!
December 12, 2024 at 1:19 PM
Gukesh Dommaraju just became the youngest ever world chess champion!
Split intein technology for gene therapy is entering the clinic. An exciting milestone for the company!
#portfolio
splice.bio/splicebio-an...
#portfolio
splice.bio/splicebio-an...
December 12, 2024 at 9:58 AM
Split intein technology for gene therapy is entering the clinic. An exciting milestone for the company!
#portfolio
splice.bio/splicebio-an...
#portfolio
splice.bio/splicebio-an...
The benchmark for $JANX's prostate cancer data release tomorrow is the STEAP1xCD3 results that $AMGN presented at #ESMO24
In summary:
- 53% PSA50, with 59% DOR at 3mo and 6% at 6mo
- 34% PSA90, 29% ORR, mRPFS 7.8mo
- 72% Gr3 AEs, 76% CRS, 69% musculoskeletal events
In summary:
- 53% PSA50, with 59% DOR at 3mo and 6% at 6mo
- 34% PSA90, 29% ORR, mRPFS 7.8mo
- 72% Gr3 AEs, 76% CRS, 69% musculoskeletal events
December 1, 2024 at 3:03 PM
The benchmark for $JANX's prostate cancer data release tomorrow is the STEAP1xCD3 results that $AMGN presented at #ESMO24
In summary:
- 53% PSA50, with 59% DOR at 3mo and 6% at 6mo
- 34% PSA90, 29% ORR, mRPFS 7.8mo
- 72% Gr3 AEs, 76% CRS, 69% musculoskeletal events
In summary:
- 53% PSA50, with 59% DOR at 3mo and 6% at 6mo
- 34% PSA90, 29% ORR, mRPFS 7.8mo
- 72% Gr3 AEs, 76% CRS, 69% musculoskeletal events
November 25, 2024 at 10:26 AM
We ran an analysis of biotech M&A: we found that a disproportionate share of the proceeds goes to public companies listed in the US. Even when excluding megamergers!
$XBI $IBB
$XBI $IBB
November 18, 2024 at 8:28 AM
We ran an analysis of biotech M&A: we found that a disproportionate share of the proceeds goes to public companies listed in the US. Even when excluding megamergers!
$XBI $IBB
$XBI $IBB
Meanwhile, over at X...
November 14, 2024 at 4:08 PM
Meanwhile, over at X...
Some competition for $RVMD at #ESMO24. Astellas' KRAS G12D degrader shows 33% ORR at the highest dose (n=12), with 42% in PDAC (n=7). Still low n, but as a reference $RVMD had a 27% ORR in Ras-mutant PDAC
September 9, 2024 at 8:49 AM
Some competition for $RVMD at #ESMO24. Astellas' KRAS G12D degrader shows 33% ORR at the highest dose (n=12), with 42% in PDAC (n=7). Still low n, but as a reference $RVMD had a 27% ORR in Ras-mutant PDAC
Midjourney always made better images than DALL-E. With its new version 6, it also gained that fine understanding of language. AGI may be coming, but at the moment AI is still highly specialized
December 21, 2023 at 9:27 PM
Midjourney always made better images than DALL-E. With its new version 6, it also gained that fine understanding of language. AGI may be coming, but at the moment AI is still highly specialized
Darwin to Margulis
December 18, 2023 at 7:23 PM
Darwin to Margulis
Some of my favorite quotes from Darwin's "On the Origin of Species":
The universal laws of life
“It is generally acknowledged that all organic beings have been formed on two great laws – Unity of Type, and the Conditions of Existence”
/1
The universal laws of life
“It is generally acknowledged that all organic beings have been formed on two great laws – Unity of Type, and the Conditions of Existence”
/1
November 27, 2023 at 12:16 PM
Some of my favorite quotes from Darwin's "On the Origin of Species":
The universal laws of life
“It is generally acknowledged that all organic beings have been formed on two great laws – Unity of Type, and the Conditions of Existence”
/1
The universal laws of life
“It is generally acknowledged that all organic beings have been formed on two great laws – Unity of Type, and the Conditions of Existence”
/1