Justin Rudd
@jrudd35.bsky.social
MD/PhD Student. CUSOM. Skin Biology
This was an exciting detour into an unexpected area of keratinocyte biology for our group! Stay tuned for implications in cutaneous SCC!
July 28, 2025 at 1:19 AM
This was an exciting detour into an unexpected area of keratinocyte biology for our group! Stay tuned for implications in cutaneous SCC!
With much help from wonderful collaborators in @simpsonlabuw.bsky.social
and Johann Gudjonsson labs, we found that dysregulation of Flower expression and subcellular localization typifies Grover and Darier disease, diseases of cornification driven by abnormal cytosolic calcium handling.
and Johann Gudjonsson labs, we found that dysregulation of Flower expression and subcellular localization typifies Grover and Darier disease, diseases of cornification driven by abnormal cytosolic calcium handling.
July 28, 2025 at 1:19 AM
With much help from wonderful collaborators in @simpsonlabuw.bsky.social
and Johann Gudjonsson labs, we found that dysregulation of Flower expression and subcellular localization typifies Grover and Darier disease, diseases of cornification driven by abnormal cytosolic calcium handling.
and Johann Gudjonsson labs, we found that dysregulation of Flower expression and subcellular localization typifies Grover and Darier disease, diseases of cornification driven by abnormal cytosolic calcium handling.
Using a combination of imaging and proteomic approaches we defined the composition of Flower-positive vesicles and showed that Flower potentiates release of intracellular calcium stores to drive surface trafficking of cargo molecules in differentiated keratinocytes.
July 28, 2025 at 1:19 AM
Using a combination of imaging and proteomic approaches we defined the composition of Flower-positive vesicles and showed that Flower potentiates release of intracellular calcium stores to drive surface trafficking of cargo molecules in differentiated keratinocytes.
With the help of Jos Smits and Ellen van den Bogaard, we found that loss of Flower significantly perturbs barrier function in organotypic epidermis and impairs delivery of LB contents to the stratum corneum.
July 28, 2025 at 1:19 AM
With the help of Jos Smits and Ellen van den Bogaard, we found that loss of Flower significantly perturbs barrier function in organotypic epidermis and impairs delivery of LB contents to the stratum corneum.
We built upon our previous work describing basic structural properties and subcellular localization of Flower isoforms to show that Flower populates LBs in the upper epidermis. www.jbc.org/article/S002...
Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4
Human Flower (hFWE) isoforms hFWE1-4 are putative transmembrane (TM) proteins that
reportedly mediate fitness comparisons during cell competition through extracellular
display of their C-terminal tail...
www.jbc.org
July 28, 2025 at 1:19 AM
We built upon our previous work describing basic structural properties and subcellular localization of Flower isoforms to show that Flower populates LBs in the upper epidermis. www.jbc.org/article/S002...