With the support of: @canceropolesud.bsky.social, Labex Signalife, @ihu-respirera.bsky.social, Institut national du cancer, CNRS Innovation and Région Sud - Provence-Alpes-Côte d'Azur !

This study carried out at @univcotedazur.bsky.social, IPMC CNRS - University Nice Sophia Antipolis, Centre Inria d'Université Côte d'Azur, @cnrsbiologie.bsky.social, @cnrscotedazur.bsky.social, @cnrs.fr.

Big thanks to Ludovic Peyre, Marielle Péré, Mickael Meyer, Benjamin Bian, Marina Moureau-Barbato, Walid Djema, @bernard-mari.bsky.social and Georges Vassaux !

Cells continuously switch between states of sensitivity: cell-states of drug-sensitivity coexist in a clonal population. The sub-population that resists apoptotic treatments will transiently exhibit features of sensitivity to necroptotic treatments, suggesting an optimal treatment sequence.

Our latest paper just came out in Molecular Systems Biology !

Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org

www.embopress.org/doi/full/10....