Jeff Saucerman
@jsauce7.bsky.social
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. https://engineering.virginia.edu/faculty/jeffrey-saucerman
January 21, 2026 at 12:21 PM
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
January 2, 2026 at 1:36 PM
Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
Snowy hike to Hawksbill Summit, Shenandoah NP
December 14, 2025 at 3:32 AM
Snowy hike to Hawksbill Summit, Shenandoah NP
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
December 10, 2025 at 2:56 AM
The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
More snow hike pics, Percival's Island, #Lynchburg
December 6, 2025 at 7:35 PM
More snow hike pics, Percival's Island, #Lynchburg
Winter wonderland 🥾❄️
December 6, 2025 at 7:29 PM
Winter wonderland 🥾❄️
Here's the comparison of time-evolving phase portraits of cardiac differentiation in WT (2 saddlenode bifurcations: mono->bi->new monostable) vs. Brm-KO (reversal of 1 saddlenode bifurcation: mono->bi->old bistable)
December 5, 2025 at 6:32 PM
Here's the comparison of time-evolving phase portraits of cardiac differentiation in WT (2 saddlenode bifurcations: mono->bi->new monostable) vs. Brm-KO (reversal of 1 saddlenode bifurcation: mono->bi->old bistable)
In contrast, as @benoitbruneau.bsky.social noted the original Waddington diagram only shows pitchfork bifurcations (2 stable states split off from 1)
December 5, 2025 at 4:39 PM
In contrast, as @benoitbruneau.bsky.social noted the original Waddington diagram only shows pitchfork bifurcations (2 stable states split off from 1)
Great questions, agreed! There are a number of possible transition types. I think this demo by my daughter of how Brahma KO breaks the second saddle node bifurcation was surprisingly our most intuitive.
December 5, 2025 at 4:37 PM
Great questions, agreed! There are a number of possible transition types. I think this demo by my daughter of how Brahma KO breaks the second saddle node bifurcation was surprisingly our most intuitive.
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
November 15, 2025 at 2:10 PM
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
November 1, 2025 at 12:14 AM
Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
October 3, 2025 at 8:24 PM
How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
Spooky fall day in Shenandoah NP
October 1, 2025 at 1:35 AM
Spooky fall day in Shenandoah NP
Finally, check out the eye candy! Awesome multi-channel live-cell videos analyzed with machine learning segmentation and tracking. Shows the complex fates that cells commit to. 3/3
September 18, 2025 at 12:03 AM
Finally, check out the eye candy! Awesome multi-channel live-cell videos analyzed with machine learning segmentation and tracking. Shows the complex fates that cells commit to. 3/3
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 18, 2025 at 12:00 AM
Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 1, 2025 at 11:54 AM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
August 26, 2025 at 9:24 PM
Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
