Huge thanks to our collaborators —
Britta Velten (@brittavelten.bsky.social)
, the Klingmüller lab at DKFZ (@klingmuelab.bsky.social), and the Winter team at Thoraxklink Heidelberg
— for their contributions 🙏
We invite you to try out msBayesImpute and welcome any feedback or suggestions! 💬

msBayesImpute works for both small and large datasets, requires no parameter tuning, and is available in R and Python. A Shiny app will be available soon!
👉 Python version: github.com/Lu-Group-UKH...
👉 R version: github.com/Lu-Group-UKH...

Across synthetic, semi-synthetic, and experimental serial dilution datasets, msBayesImpute consistently:
✅ Achieved the lowest imputation error
✅ Improved sample-wise normalization
✅ Delivered the highest accuracy in DE analysis across 9 methods

Missing values in proteomics are often not missing at random (MNAR). Existing methods either assume MAR or oversimplify MNAR.
💡 msBayesImpute learns protein-specific dropout curves directly from the data using Bayesian matrix factorization + probabilistic dropout models.

🚀 Excited to share our new preprint: msBayesImpute - A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data
👉 Improves imputation accuracy, normalization, and differential expression detection
📝https://www.biorxiv.org/content/10.1101/2025.10.02.679746v1

🚀 Postdoc / Bioinformatician in Computational Multi-Omics for Precision Oncology at Heidelberg University Hospital: karriere.klinikum.uni-heidelberg.de/index.php?ac...
A great short-term opportunity for anyone looking for a bridge position between PhD, postdoc, or the next career step.

We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare!

You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.

👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application

🔬 PhD Position in Bioinformatics!
Join my group at Heidelberg University (lu-group-ukhd.github.io) to study AML dormancy & therapy resistance using multi-omics & single-cell data.
👉Apply or share: www.jobvector.de/job/bioinfor...