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Kaessmann Lab

@kaessmannlab.bsky.social

590 followers 180 following 99 posts

Our research group is interested in the molecular and cellular origins and evolution of vertebrate organs. Tweets by Henrik, usually in the name of our group. home.kaessmannlab.org

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

www.nature.com

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Kaessmann Lab @kaessmannlab.bsky.social · 27d

👇 !!!

Louis-Jeantet Foundation @louisjeantetfdn.bsky.social · 29d

Register to attend the #LouisJeantetSymposium on vertebrate genome #evolution. Organised by Svante Pääbo and
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/

📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social

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Reposted by Kaessmann Lab

Fernando Garcia-Moreno @phylobrain.bsky.social · Aug 26

🚨 PhD opportunity!
Join our group at @AchucarroNeuro (Bilbao, Spain) for a 4-year bioinformatics PhD on brain evolution 🧠🧬
Work with scRNA-seq & spatial transcriptomics to uncover how the THALAMUS diversified across amniotes!

📩 Apply: [email protected]

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Reposted by Kaessmann Lab

Idoia Quintana-Urzainqui @idoiaeu.bsky.social · Sep 2

🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 27

Congrats Gray and all!! So cool to see that this fantastic work is out now!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 19

…and yes, they do - your miR-17~92 story is also very cool..

Kaessmann Lab @kaessmannlab.bsky.social · Jul 19

…and congrats to you, Magdalena and Fany et al. on the wonderful bat study, which I saw is out in NEE now!!

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 19

Many thanks Dario!! Hope all is well!

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 19

Thanks so much Leo! All the best

Kaessmann Lab @kaessmannlab.bsky.social · Jul 19

Thank you!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 18

Thank you!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 18

Many thanks Arnau!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 17

Many thanks Sergio!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 17

Thanks a lot Arnaud!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 17

Many thanks Axel!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 17

Thank you very much!!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 17

Many thanks Uri!

Reposted by Kaessmann Lab

ZMBH @zmbh.uni-heidelberg.de · Jul 17

@kaessmannlab.bsky.social has for the first time shown in an international collaboration, that survival of male birds crucially depends on a micro RNA for sex chromosome dosage compensation. The paper just has been published by Nature.
www.nature.com/articles/s41...

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature

www.nature.com

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

Thanks so much Margarida for your (as usual) invaluable contributions!!

Reposted by Kaessmann Lab

Universität Heidelberg @uniheidelberg.bsky.social · Jul 16

How a Tiny Gene Ensures the Survival of Male Birds – Researchers from Heidelberg and Edinburgh identify a mechanism that balances the genetic disparity between sex chromosomes
www.uni-heidelberg.de/en/newsroom/...

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

Many thanks Fillip!!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

Thanks so much Edda!! Many thanks also for your comment in the Research Briefing and the invaluable comments (we assume ;-)) on the paths to publication... Best!

Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

While the silencing mechanism in mammals involves a transcriptional shutdown of most of the X chromosome, birds evolved a highly targeted post-transcriptional mechanism that specifically silences upregulated dosage sensitive Z-linked genes.

Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

These mechanisms, however, show striking differences, although they all involve noncoding RNAs as key mediators (miR-2954 in birds; the long noncoding RNAs XIST and RSX in placentals and marsupials, respectively) and are essential for the viability of the homogametic sex.

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Kaessmann Lab @kaessmannlab.bsky.social · Jul 16

That is, the decay of the sex chromosome specific to the heterogametic sex (the W or Y) triggered upregulation of the sex chromosome common to both sexes (the Z or X), necessitating the evolution of secondary silencing mechanisms in male (ZZ) birds and female (XX) mammals.