Kaleb Negussie
@kaleb-negussie.bsky.social
BrownU Neuroscience undergrad | Biotech investment analyst
Reposted by Kaleb Negussie
Almost every review I've ever read about myeloma #MMsm starts with something (true) like, "Recent advances in myeloma have led to significant improvements in..."
Quite a jolt to see how different the prognosis was for myeloma 60 years ago... and how these papers used to begin!
Quite a jolt to see how different the prognosis was for myeloma 60 years ago... and how these papers used to begin!
November 30, 2024 at 5:03 AM
Almost every review I've ever read about myeloma #MMsm starts with something (true) like, "Recent advances in myeloma have led to significant improvements in..."
Quite a jolt to see how different the prognosis was for myeloma 60 years ago... and how these papers used to begin!
Quite a jolt to see how different the prognosis was for myeloma 60 years ago... and how these papers used to begin!
Reposted by Kaleb Negussie
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kaleb Negussie
So thrilled to have this out! This was a really fun collaboration with Hanna Ollila that we chipped away at together over the last several years with lots of help from both our groups.
An innate immune checkpoint involved in platelet level maintenance - important to consider with CD47 blockade.
An innate immune checkpoint involved in platelet level maintenance - important to consider with CD47 blockade.
SIRPα controls CD47-dependent platelet clearance in mice and humans https://www.biorxiv.org/content/10.1101/2023.12.09.570874v1
SIRPα controls CD47-dependent platelet clearance in mice and humans https://www.biorxiv.org/content/10.1101/2023.12.09.570874v1
Over the last decade, more data has revealed that increased surface expression of the "don't eat me"
www.biorxiv.org
December 11, 2023 at 2:31 PM
So thrilled to have this out! This was a really fun collaboration with Hanna Ollila that we chipped away at together over the last several years with lots of help from both our groups.
An innate immune checkpoint involved in platelet level maintenance - important to consider with CD47 blockade.
An innate immune checkpoint involved in platelet level maintenance - important to consider with CD47 blockade.