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karlgademann.bsky.social
Karl Gademann
@karlgademann.bsky.social
670 followers 530 following 11 posts
Organiker. Synthetiker.
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Karl Gademann @karlgademann.bsky.social · Dec 19
Unusual heterocycles and biosynthesis of natural products, published today in Communications Chemistry 🧵
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Reposted by Karl Gademann
orgbiomolchem.rsc.org
Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · May 26
🔓Take a look at this #OpenAccess research in our latest issue from @karlgademann.bsky.social & co on the synthesis of 2-acetylnoviosamine derivatives by hydrogenolytic cleavage of a spirocyclopropane #orgchem

📍‪‪ @chem-uzh-ch.bsky.social
pubs.rsc.org/en/content/a...
Synthesis of 2-acetylnoviosamine derivatives by hydrogenolytic cleavage of a spirocyclopropane
The preparation of a 2-acetamido derivative of the rare 5,5-gem-dimethyl-deoxy carbohydrate noviose is reported in this study. The synthesis starts from readily available N-acetyl-d-mannosamine and…
pubs.rsc.org
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Karl Gademann @karlgademann.bsky.social · May 8
Final presentation at the Bürgenstock conference: Todd Hyster from Princeton #bc_scs25
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Karl Gademann @karlgademann.bsky.social · Feb 19
Start of the 2025 Irsee conference by @HartungIngo , Looking forward to three exciting days of natural product chemistry!
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Karl Gademann @karlgademann.bsky.social · Jan 9
We are hiring! Exciting project on the performance enhancement of peptides. Check out and share: jobs.uzh.ch/job-vacancie...
UZH: PhD Student Position in Peptide Chemistry
A PhD Student position is available in the group of Prof. Dr. Karl Gademann, located in the Department of Chemistry at the University of Zurich (Switzerland). Our group combines the synthesis of natur...
jobs.uzh.ch
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
And congratulations to the whole team involved! /fin
karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
Read more in our study published at www.nature.com/articles/s42...
Functional biosynthetic stereodivergence in a gene cluster via a dihydrosydnone N-oxide - Communications Chemistry
The ham gene cluster in Burkholderia cenocepacia H111 produces two compounds: the signalling molecule valdiazen as racemate and the antifungal fragin in enantiopure form. Here, the authors demonstrate...
www.nature.com
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
I always wanted to work with sydnones, and now these are competent biosynthetic intermediates! And we have an X-ray crystal structure
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
Now comes the unusual finding ... an unusual heterocycle is involved in both biosyntheses in a stereodivergent fashion
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
On top of this, highly unusual that both a racemic compound and an enantiomerically pure compound are derived from the same biosynthetic gene cluster.
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
The biosynthesis of diazeniumdiolates (yes this strange functional group) remains enigmatic
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 19
Unusual heterocycles and biosynthesis of natural products, published today in Communications Chemistry 🧵
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karlgademann.bsky.social
Karl Gademann @karlgademann.bsky.social · Dec 17
The great chemistry bake off at UZH, congrats to Ana and Erik for the most artistic cake!
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