Alexander Karollus
@karollus.bsky.social
There was also a paper suggesting a (maybe similar?) mechanism involving ALU repeats. I sometimes wonder whether enhancer-promoter is a lot more hodge-podge than very fancy 3D folding theories suggest. www.nature.com/articles/s41...
Complementary Alu sequences mediate enhancer–promoter selectivity - Nature
Using RNA in situ conformation sequencing technology, the role of Alu elements in mediating the interaction between enhancers and promoters is shown.
www.nature.com
January 10, 2025 at 10:31 AM
There was also a paper suggesting a (maybe similar?) mechanism involving ALU repeats. I sometimes wonder whether enhancer-promoter is a lot more hodge-podge than very fancy 3D folding theories suggest. www.nature.com/articles/s41...
Sorry if I am misunderstanding, but is this not what we would expect? By design PIP lower than 0.x should mean > x% false positives, so false positives with PIP < 0.9 is normal, no?
November 21, 2024 at 11:08 PM
Sorry if I am misunderstanding, but is this not what we would expect? By design PIP lower than 0.x should mean > x% false positives, so false positives with PIP < 0.9 is normal, no?