Karthik's Host-patho lab, India
@karthiks-lab.bsky.social
Bacterial pathogenesis and Host- pathogen interaction laboratory led by Dr. Karthik Subramanian, BRIC-RGCB, India. We study extracellular vesicles, bacterial persistence and novel antimicrobials in the context of pneumococcal infections.
Pinned
🚨New Preprint! Excited to share our latest work on tackling Streptococcus pneumoniae, a major cause of pneumonia and meningitis worldwide - a WHO priority pathogen.
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
Our lab 🧫 turns 5! 🎉
Our mission: investigating pneumococcal infections via 3 strategic ways: Extracellular Vesicles, AMR drug repurposing, immune profiling.
✅ 4 Projects
✅ 3+ Publications
✅ Training 4 PhD students, 20+ MSc Trainees
Thanks to my brilliant team-past & present for the dedication!
Our mission: investigating pneumococcal infections via 3 strategic ways: Extracellular Vesicles, AMR drug repurposing, immune profiling.
✅ 4 Projects
✅ 3+ Publications
✅ Training 4 PhD students, 20+ MSc Trainees
Thanks to my brilliant team-past & present for the dedication!
December 11, 2025 at 5:55 PM
Our lab 🧫 turns 5! 🎉
Our mission: investigating pneumococcal infections via 3 strategic ways: Extracellular Vesicles, AMR drug repurposing, immune profiling.
✅ 4 Projects
✅ 3+ Publications
✅ Training 4 PhD students, 20+ MSc Trainees
Thanks to my brilliant team-past & present for the dedication!
Our mission: investigating pneumococcal infections via 3 strategic ways: Extracellular Vesicles, AMR drug repurposing, immune profiling.
✅ 4 Projects
✅ 3+ Publications
✅ Training 4 PhD students, 20+ MSc Trainees
Thanks to my brilliant team-past & present for the dedication!
Excited to talk about the lab's latest research on extracellular vesicles in @isev.org EVs in Immunity, Athens next week.
https://www.isev.org/evs-in-immunity
#EVsInImmunity #ISEV
https://www.isev.org/evs-in-immunity
#EVsInImmunity #ISEV
November 2, 2025 at 4:24 AM
Excited to talk about the lab's latest research on extracellular vesicles in @isev.org EVs in Immunity, Athens next week.
https://www.isev.org/evs-in-immunity
#EVsInImmunity #ISEV
https://www.isev.org/evs-in-immunity
#EVsInImmunity #ISEV
I’m pleased to share that I’ve been inducted into the Editorial Board of Microbiology Spectrum, American Society for Microbiology. Looking fwd to work with journal to advancing excellence in microbiological research and publishing.
journals.asm.org/journal/spec...
#Microbiology #ASM #Science
journals.asm.org/journal/spec...
#Microbiology #ASM #Science
Microbiology Spectrum Reviewing Editors
Current Microbiology Spectrum Reviewing Editors
journals.asm.org
October 7, 2025 at 4:03 PM
I’m pleased to share that I’ve been inducted into the Editorial Board of Microbiology Spectrum, American Society for Microbiology. Looking fwd to work with journal to advancing excellence in microbiological research and publishing.
journals.asm.org/journal/spec...
#Microbiology #ASM #Science
journals.asm.org/journal/spec...
#Microbiology #ASM #Science
Had an incredibly enriching four days at the RGCB Research Conference in beautiful Munnar!
The scientific sessions were cutting-edge and a true honor to hear from Nobel laurate, Prof. Morten Meldal. It was also great to catch up with Dhiraj Kumar from ICGEB and Puran Sijwali from CCMB Hyderabad.
The scientific sessions were cutting-edge and a true honor to hear from Nobel laurate, Prof. Morten Meldal. It was also great to catch up with Dhiraj Kumar from ICGEB and Puran Sijwali from CCMB Hyderabad.
September 2, 2025 at 3:05 PM
Had an incredibly enriching four days at the RGCB Research Conference in beautiful Munnar!
The scientific sessions were cutting-edge and a true honor to hear from Nobel laurate, Prof. Morten Meldal. It was also great to catch up with Dhiraj Kumar from ICGEB and Puran Sijwali from CCMB Hyderabad.
The scientific sessions were cutting-edge and a true honor to hear from Nobel laurate, Prof. Morten Meldal. It was also great to catch up with Dhiraj Kumar from ICGEB and Puran Sijwali from CCMB Hyderabad.
🚨New Preprint! Excited to share our latest work on tackling Streptococcus pneumoniae, a major cause of pneumonia and meningitis worldwide - a WHO priority pathogen.
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
August 15, 2025 at 11:28 AM
🚨New Preprint! Excited to share our latest work on tackling Streptococcus pneumoniae, a major cause of pneumonia and meningitis worldwide - a WHO priority pathogen.
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
📄 Read doi.org/10.1101/2025...
#AntibioticResistance #DrugRepurposing #PneumoniaResearch #StreptococcusPneumoniae #Antivirulence
Very cool indeed! The mechanism of NET-thrombin binding and the potential for antisense LNA therapy opens up exciting avenues for treating dangerous clots. Great work highlighted here!
Very cool
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis | PNAS
Neutrophils release neutrophil extracellular traps (NETs) to neutralize infections,
a process that also contributes to immunothrombosis. While bene...
www.pnas.org
July 7, 2025 at 5:51 PM
Very cool indeed! The mechanism of NET-thrombin binding and the potential for antisense LNA therapy opens up exciting avenues for treating dangerous clots. Great work highlighted here!
Celebrating graduation of two MSc thesis students, Sudarshan and Sreerenjini from the lab. Sudarshan worked on screening virulence inhibitors while Sreerenjini worked on Extracellular vesicles Humbled to receive the "Best Guru" memento from these amazing young scientists. Go conquer the world!
June 22, 2025 at 1:53 PM
Celebrating graduation of two MSc thesis students, Sudarshan and Sreerenjini from the lab. Sudarshan worked on screening virulence inhibitors while Sreerenjini worked on Extracellular vesicles Humbled to receive the "Best Guru" memento from these amazing young scientists. Go conquer the world!
A national symposium was organized to honor superannuating scientists, Dr. Moinak and Dr. Soniya from Rajiv Gandhi Centre for Biotechnology. They described their journey inspirations followed by scientific poster sessions. Aswathy presented her existing findings in her poster gathering wide interest
May 17, 2025 at 5:04 AM
A national symposium was organized to honor superannuating scientists, Dr. Moinak and Dr. Soniya from Rajiv Gandhi Centre for Biotechnology. They described their journey inspirations followed by scientific poster sessions. Aswathy presented her existing findings in her poster gathering wide interest
Lithocolic acid identified as key metabolite promoting longevity during CR.
Holy Ponce de Leon!
New in Nature: Administration of a single molecule, the calorie restriction-upregulated metabolite LITHOCHOLIC ACID, confers anti-ageing benefits to mice, Drosophila, and C. elegans in an AMPK-dependent manner
www.nature.com/articles/s41...
Do you really want to live forever?
New in Nature: Administration of a single molecule, the calorie restriction-upregulated metabolite LITHOCHOLIC ACID, confers anti-ageing benefits to mice, Drosophila, and C. elegans in an AMPK-dependent manner
www.nature.com/articles/s41...
Do you really want to live forever?
December 25, 2024 at 2:01 AM
Lithocolic acid identified as key metabolite promoting longevity during CR.
Pleasure to share our latest story from my laboratory on bacterial virulence inhibitors at the International AMR symposium #ALARM2024 at Amrita School of Biotechnology. Special thanks Dr. Bipin and @Geetha Kumar.
Congrats to my student, Joel for winning the best poster award 👏
@nizet.bsky.social
Congrats to my student, Joel for winning the best poster award 👏
@nizet.bsky.social
November 24, 2024 at 4:30 PM
Pleasure to share our latest story from my laboratory on bacterial virulence inhibitors at the International AMR symposium #ALARM2024 at Amrita School of Biotechnology. Special thanks Dr. Bipin and @Geetha Kumar.
Congrats to my student, Joel for winning the best poster award 👏
@nizet.bsky.social
Congrats to my student, Joel for winning the best poster award 👏
@nizet.bsky.social
Hello bluesky! Thus is our first tweet here. We are a curious bunch of scientists working on infection biology at Rajiv Gandhi Centre for Biotechnology, India. Look forward to connecting with fellow scientists. Please like and message so I can connect.
November 20, 2024 at 5:18 PM
Hello bluesky! Thus is our first tweet here. We are a curious bunch of scientists working on infection biology at Rajiv Gandhi Centre for Biotechnology, India. Look forward to connecting with fellow scientists. Please like and message so I can connect.