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kathleen-leeper.bsky.social
kathleen leeper
@kathleen-leeper.bsky.social
26 followers 30 following 4 posts
barcoding (and reading out) the mouse connectome @ e11.bio. I play with DNA and I help build teams. prev: kalhor lab @ JHU, church lab @ harvard
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kathleen-leeper.bsky.social
kathleen leeper @kathleen-leeper.bsky.social · 7d
paired with our preprint -- the PRISM collection on Addgene! This also includes unpublished Cre-dependent vectors to label your favorite circuits -- big shoutout here to Michelle Wu for cloning, design work, and coordination (and a joy to work with in general)
addgene.bsky.social
Addgene @addgene.bsky.social · 8d
New AAV tools from @e11bio.bsky.social! PRISM uses protein-tag barcodes for high-throughput reconstruction of neurons and other cell-labeling applications. https://twp.ai/4iruEB
A 3D rendering of a network of neurons from a rectangular volume. Each neuron is filled with a slightly different color, making each cell body and its projections distinct from its neighbors.
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kathleen-leeper.bsky.social
kathleen leeper @kathleen-leeper.bsky.social · 7d
if you are a personal friend i will be taking champagne in support of this work
kathleen-leeper.bsky.social
kathleen leeper @kathleen-leeper.bsky.social · 7d
hello, we are working on brain mapping and now you can read about it! it has beautiful neurons (shout out to cell 1492), cool multiplexing tricks, and cell barcodes. there are live data links, my first addgene collection and much much more
andrewcpayne.bsky.social
Andrew Payne @andrewcpayne.bsky.social · 8d
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism
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kathleen-leeper.bsky.social
kathleen leeper @kathleen-leeper.bsky.social · Dec 3
inaugural post for an inaugural demonstration of our work! extremely proud of this and what we have for the future of #neuroscience & ai

briefly: we (e11) make brains super colorful 🌈and super big 🧠, and then we build a map of how every neuron talks to every other neuron
andrewcpayne.bsky.social
Andrew Payne @andrewcpayne.bsky.social · Dec 3
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.

Read more: e11.bio/news/roadmap
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