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Kevin C Klatt, PhD, RD

@kcklatt.bsky.social

4.8K followers 620 following 490 posts

Incoming Assistant Prof, @uoftnutrisci.bsky.social . #Metabolism Researcher, #Dietitian. Associate Editor, American Journal of Clinical Nutrition. 🎙️Host, 'AJCN In Press' 🎙️ By way of: UC Berkeley, Baylor CoM, NIH, Cornell Kcklatt.substack.com

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · Aug 25

This year's Annual Review of Nutrition is out and full of really great reads.

My contribution details the broad history of nutritional guidance in America & covers the forces (science/politics/culture) that have driven the evolution of nutrition guidance.

www.annualreviews.org/content/jour...

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 7d

Peer Review reports went live on the 'Harvard' citation the administration is using to support the Tylenol-Autism/ADHD link. Pretty eyebrow raising

ehjournal.biomedcentral.com/articles/10....

Environmental Health

Established in 2002, Environmental Health has an international readership and is rated in the top 25% of journals in this field. It covers primarily original ...

ehjournal.biomedcentral.com

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 7d

Nancy Mace on Bill Maher telling pregnant women to take Ibuprofen instead of Tylenol is so emblematic of everything wrong with this administrations approach to health.

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Reposted by Kevin C Klatt, PhD, RD

Kevin Hall @kevinh-phd.bsky.social · 8d

It was a pleasure to chat with @drjessicaknurick.bsky.social about ultra-processed foods and other topics discussed in my new book Food Intelligence co-authored with @juliabelluz.bsky.social.

substack.com/home/post/p-...

Ultraprocessed Foods with Dr. Kevin Hall

Few scientists have shaped the way we understand nutrition and metabolism as much as Dr.

substack.com

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 10d

But Nope, just a silver bullet political win that's causing chaos over access to leucovorin & parents left to plan restrictive diets alone while getting mixed information online

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 10d

The admin didn't have to do any of this. This could've been a funding announcement for a well powered multi center trial of leucovorin that considered key covariates. They could've pushed Congress behind the scenes to expand access to dietitian coverage for individuals with autism.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 10d

Sad for parents desperate for help & being heard online now paying for genetic tests, designer vitamins, & bending over backwards to feed restrictive diets they've been told are toxic. Sad for the kids w autism being fed restrictive diets, some of which will inevitably be imbalanced & cause harm.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 10d

The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 10d

FYI Jenny McCarthy is now out here promoting the Tylenol - Autism link citing its impact on glutathione and promoting IV infusions of glutathione.

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 11d

and for folks who don't follow this, it is nearly all naturopaths, chiropractors and 'integrative' medicine folks who are pushing the glutathione rationale b/c they get to sell N-acetylcysteine & Vitamin C supplements (of which there are many poorly contextualized papers out there also hyping).

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 11d

So many papers are clearly written to sex up impact and claim translatability, at the expense of accuracy - that's a gift to pseudoscience. We need to be training the next generation of scientists to be honest and media literate.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 11d

Every basic scientist & PhD program director should be watching how cell culture and rodent models of Tylenol exposure are being used by motivated parties (e.g. it depletes your glutathione! Science proves it PMID...) to sell a narrative and sow confusion right now.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 13d

honored to be colleagues with so many greats like yourself! 🤗

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 14d

It is a great nutrition and metabolism community with folks like @danieljdrucker.bsky.social there! & That is high praise from Dave!!

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 14d

Really excited to announce that I've accepted an Assistant Professor position in the Department of Nutritional Sciences in the Faculty of Medicine at the University of Toronto! Looking forward to venturing north (🥶) & building out my own research group focused on human nutrition & metabolism 🥳

uoftnutrisci.bsky.social @uoftnutrisci.bsky.social · 14d

Big news! Thrilled to welcome Dr. Kevin Klatt as our newest Assistant Professor in Nutritional Sciences! From Cornell → NIH → Baylor → UC Berkeley, he brings expertise in maternal & infant nutrition + micronutrients! Join us in welcoming him! @kcklatt.bsky.social @uoftmedicine.bsky.social

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 14d

Excited to listen to the new nutrition science book from @kevinh-phd.bsky.social & @juliabelluz.bsky.social !

It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science.

amzn.to/42akyvM

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

How will this help ensure Medicaid coverage for general ASD?

Not just a flub of the white house comms - GSK is confirming the new indication for CFD and even highlights that it's rare
www.gsk.com/en-gb/media/...

GSK to submit label update for Wellcovorin (leucovorin) at US FDA’s request | GSK

GSK confirmed today that it will submit a supplemental New Drug Application (sNDA) for Wellcovorin (leucovorin)

www.gsk.com

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

It's very bizarre that the admin pursued a leucovorin indication for children with cerebral folate deficiency and autism symptoms, not for general autism. CFD is rare and the diagnosis is confirmed by measuring folate levels in cerebrospinal fluid, which most general cases of autism won't have.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

I will never disappoint when it comes to EXTREMELY niche nutrition content 😂

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

For an admin that loves to weaponize the quality of the science behind COVID pandemic public health restrictions and emphasizes needing gold standard science, it's interesting we are inflating the risks of Tylenol & benefits of Leucovorin based on pretty weak evidence

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

The hilariously butchered pronouncement of acetaminophen makes me really wish someone had tried to call leucovorin by its chemical name, 5-formyltetrahydrofolate

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

As the admin continues to purport to have found environmental causes of autism (& pretend to care about nutrition), I find myself thinking a lot the failed National Children's Study. There's a push to have answers w/o reckoning w the reality of the studies we haven't done
undark.org/2016/05/25/t...

The Death of the National Children's Study: What Went Wrong?

Over the course of 14 years, an ambitious study of childhood disease became what critics call a $1.3 billion "scientific humiliation" for the United States.

undark.org

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

Push back on leucovorin and folinic acid as a cure all. it is an early stage investigational therapy for a subset of children with autism. It is wild to me that the admin saying public health damaged itself during COVID is now set to overstate the efficacy of a treatment for autism.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

- Dosing will be a mess because folate is listed as micrograms and its in both the amount of the form used and dietary folate equivalents

-Folinic acid comes as isomers (D- and L-) with only the L- being biologically active. The pharma version are 1:1 D- and L-. Most supps don't even state the mix

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 15d

With the inevitable coming shortages of leuocovorin, there's going to be a huge push for influencers (& folks in our government) to profit off of folinic acid supplements. A few things:

-doses used in trials are pharmacological and the OTC supplemental versions will last a few days to maybe a week.

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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 16d

There's going to be a push to present this as a cure all when there are deep uncertainties and the preliminary evidence already only points to sunsets of pts that are likely to benefit