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Reposted by Kevin Monahan

ralucagordan.bsky.social @ralucagordan.bsky.social · 6d

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

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Reposted by Kevin Monahan

St Mark’s Hospital and Academic Institute @stmarkshospital.bsky.social · 5d

Can we prevent IBD?

We are delighted to have Prof. Johan Burisch as one of our visiting professors for this years Frontiers congress 🙌🏻

Hear more about Prof. Burisch in the video below ⬇️

Register now - bit.ly/4ktsvDc

@lnwh.bsky.social
@kevinmonahan.bsky.social

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 8d

Final Call for Abstracts – Deadline Today!⏳

Don't miss your chance to be part of the #InSiGHT2026 Biennial Meeting in #Singapore! 🌏

🗓️ Submission Deadline: 30 September 2025
⏰ Time: Midnight (Singapore Time) / 6pm CET

Submit your abstract now! insight2026.org/abstract-sub...

#Genetics #GIcancer

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 9d

🚨 Final Call: Abstract submissions for #InSiGHT2026 close TOMORROW – Sept 30!

Join the global conversation on hereditary GI tumours.
Submit now 👉 insight2026.org

Let your research drive progress.

#MedicalResearch #Genetics #GIcancer #AbstractSubmission

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Kevin Monahan @kevinmonahan.bsky.social · 11d

Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history

onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com

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Kevin Monahan @kevinmonahan.bsky.social · 11d

Genetic testing appears to have limited utility in SPS patients and may primarily identify those with an incidental diagnosis of Lynch syndrome

pubmed.ncbi.nlm.nih.gov/41002021/

Low Yield of Genetic Testing in Serrated Polyposis Syndrome - PubMed

Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing appears to have...

pubmed.ncbi.nlm.nih.gov

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Reposted by Kevin Monahan

Calum Gabbutt @calumgabbutt.bsky.social · 28d

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc

Fluctuating DNA methylation tracks cancer evolution at clinical scale

Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

rdcu.be

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Reposted by Kevin Monahan

Vaughn Cooper @vscooper.micropopbio.org · 17d

Lineage tracking using methylation states from longitudinal bulk sampling. Sounds 🆒 and given recent work by @trevorgraham.bsky.social and colleagues, looks real.

Wondering about other applications like 🦠🧫

👉🏻News and views: www.nature.com/articles/d41...
👉🏻Paper
www.nature.com/articles/s41...

Epigenetic clues from cancer’s past foretell its future

An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

www.nature.com

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 19d

🚨 It’s here!
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines

#InSiGHT2026 #HereditaryCancer #GICancerResearch

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · 27d

🚀 Exciting news! We’re launching Young-Insight for InSiGHT members under 40.
Join our first meeting to share ideas & shape the future of our community. Email [email protected] with subject “Young Insight” to get involved! 🌍✨ #InSiGHT

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Kevin Monahan @kevinmonahan.bsky.social · Sep 6

The registries’ combined experiences underscore the critical need for integrated, culturally sensitive strategies combining genetic testing, enhanced surveillance, and family-based management to improve outcomes #Polyposis #LynchSyndrome

link.springer.com/article/10.1...

Comparative insight: hereditary colorectal cancer registries in Iran, Singapore, and South Africa - Familial Cancer

This study compares three hereditary colorectal cancer (CRC) registries—the Iranian Hereditary Colorectal Cancer Registry (IHCCR), the Singapore Polyposis Registry (SPR), and the University of Cape To...

link.springer.com

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · Aug 8

📢 Join us in Singapore for the InSiGHT Biennial Meeting,
4–7 March 2026!

🔹 Abstract Deadline: 20 Sept 2025
🔹 Early Bird: 10 Jan 2026

Link ➡️ insight2026.org

Let’s advance hereditary GI cancer research together!
#InSiGHT2026 #MedicalResearch #GItumours

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Kevin Monahan @kevinmonahan.bsky.social · Aug 11

Come and work with us!
We are seeking a Regional #LynchSyndrome Nursing Lead band 8 for 12 months to provide teaching and training across North London #Genomics apps.trac.jobs/job-advert/7...

Regional Lynch Syndrome Nursing Lead | Job advert | Trac

apps.trac.jobs

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Reposted by Kevin Monahan

Kevin Monahan @kevinmonahan.bsky.social · Jul 21

Please follow @insight-org.bsky.social on BlueSky and join us for insight2026.org in Singapore, abstract submission now live!

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Kevin Monahan @kevinmonahan.bsky.social · Jul 21

Please follow @insight-org.bsky.social on BlueSky and join us for insight2026.org in Singapore, abstract submission now live!

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Reposted by Kevin Monahan

International Society for Gastrointestinal Hereditary Tumours @insight-org.bsky.social · Jul 21

👋 Welcome to InSiGHT on BlueSky!

We are a global community of researchers, clinicians, and scientists dedicated to advancing the understanding, diagnosis, and management of hereditary GI cancers. Follow us for updates on scientific advances, clinical guidelines, and upcoming events. #InSiGHT

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Kevin Monahan @kevinmonahan.bsky.social · Jul 13

Abstract submission is now open for #Insight2026 ! Deadline 7th September #LynchSyndrome #Polyposis #EOCRC @soniakupfer.bsky.social @swatipatelmd.bsky.social @cgaigc.com @stmarksgenomics.bsky.social @plsdatabase.bsky.social

insight2026.org

InSIGHT 2026

REGISTRATION NOW OPEN Register NowCall for Abstracts Now Open! Submit Your AbstractWelcome MessageWelcome to Singapore, Selamat Datang, 欢迎, வருக வருக. On behalf of InSiGHT, we are delighted to invite....

insight2026.org

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Kevin Monahan @kevinmonahan.bsky.social · Jul 7

Mainstreaming clinicians in colorectal and Gynae teams… think about this study!

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Reposted by Kevin Monahan

Kevin Monahan @kevinmonahan.bsky.social · Jul 1

Join us 19-21 November for a bigger and better St Mark's Frontiers in Colorectal Disease Meeting, in a beautiful venue in King's Cross London!
Extremely good value, with hybrid options @stmarkshospital.bsky.social

sayso.health/events/front...

St Mark's Frontiers 2025

Register now for our Annual Frontiers in Colorectal and Intestinal Disease Congress, from the 19th–21st November 2025.

sayso.health

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Kevin Monahan @kevinmonahan.bsky.social · Jul 1

Join us 19-21 November for a bigger and better St Mark's Frontiers in Colorectal Disease Meeting, in a beautiful venue in King's Cross London!
Extremely good value, with hybrid options @stmarkshospital.bsky.social

sayso.health/events/front...

St Mark's Frontiers 2025

Register now for our Annual Frontiers in Colorectal and Intestinal Disease Congress, from the 19th–21st November 2025.

sayso.health

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Kevin Monahan @kevinmonahan.bsky.social · Jun 26

Missed opportunities: Germline testing following tumor sequencing

pubmed.ncbi.nlm.nih.gov/40554180/

Missed opportunities: Germline testing following tumor sequencing - PubMed

In this cohort, 60 % of the eligible population by ESMO criteria did not receive GT, most commonly due to lack of referral (over 2/3 of patients). Further, 50 % of patients not referred for GT had mut...

pubmed.ncbi.nlm.nih.gov

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Kevin Monahan @kevinmonahan.bsky.social · Jun 24

Great to meet up with Pam from Lynch Syndrome UK at BSG Live 2025 in Glasgow today! @thepoodoctor.bsky.social @lynchsyndromeuk.bsky.social @stmarksgenomics.bsky.social

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Reposted by Kevin Monahan

Kevin Monahan @kevinmonahan.bsky.social · Jun 10

On behalf of InSiGHT, we are delighted to welcome you to the #InSiGHT2026 meeting in Singapore, taking place from 4 – 7 March 2026 #LynchSyndrome #Polyposis @cgaigc.com @stmarksgenomics.bsky.social

insight2026.org

InSIGHT 2026

REGISTRATION NOW OPEN Register NowCall for Abstracts Now Open! Submit Your AbstractWelcome MessageWelcome to Singapore, Selamat Datang, 欢迎, வருக வருக. On behalf of InSIGHT, we are delighted to invite....

insight2026.org

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Kevin Monahan @kevinmonahan.bsky.social · Jun 10

On behalf of InSiGHT, we are delighted to welcome you to the #InSiGHT2026 meeting in Singapore, taking place from 4 – 7 March 2026 #LynchSyndrome #Polyposis @cgaigc.com @stmarksgenomics.bsky.social

insight2026.org

InSIGHT 2026

REGISTRATION NOW OPEN Register NowCall for Abstracts Now Open! Submit Your AbstractWelcome MessageWelcome to Singapore, Selamat Datang, 欢迎, வருக வருக. On behalf of InSIGHT, we are delighted to invite....

insight2026.org

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