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Reposted by Kevin Murach

PNAS Nexus @pnasnexus.org · 6d

Issue 9 (2025) of PNAS Nexus is now available! Discover how satellite cells orchestrate immune-fibrogenic circuits in aging muscle, machine learning for long-term scratching in mice, and more. Read here: https://ow.ly/bLeP50X5JVE

PNAS Nexus – Issue 9 (2025) is now available. PNASnexus.org

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Kevin Murach @kevinmurachphd.bsky.social · 24d

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.

onlinelibrary.wiley.com

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Kevin Murach @kevinmurachphd.bsky.social · Sep 1

Final version in @pnasnexus.org “Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” academic.oup.com/pnasnexus/ar...

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle

Abstract. Muscle stem cells, or satellite cells (SCs), decline in number throughout the lifespan and may become senescent in very old age. Whether and how

academic.oup.com

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Reposted by Kevin Murach

Aneesha Dasgupta @aneedasgupta.bsky.social · Aug 23

Dasgupta Lab at UNC Charlotte is hiring!
This space needs to be filled with laughter, breakthroughs, failures, high fives and everything in between! (Of course equipment!😛)
We will be studying cancer-induced muscle wasting!
DM or email for more info!
@cancercachexia.bsky.social
#myoblue

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Kevin Murach @kevinmurachphd.bsky.social · Aug 13

Prioritizing skeletal muscle health for successful aging “The beneficial effects of exercise on skeletal muscle cannot be overstated, and the impact of healthy skeletal muscle on successful aging should not be underestimated.” www.openaccessgovernment.org/article/prio...

Prioritizing skeletal muscle health for successful aging

Kevin A. Murach talks us through prioritizing skeletal muscle health for successful aging, beginning with a primer on skeletal muscle aging

www.openaccessgovernment.org

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Kevin Murach @kevinmurachphd.bsky.social · Aug 6

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Kevin Murach @kevinmurachphd.bsky.social · Aug 6

“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...

Muscle memory theory: A critical evaluation

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Kevin Murach @kevinmurachphd.bsky.social · Aug 1

Our Special Issue is live in J Physiology! w/ @mvfranchi.bsky.social & Prof. Paul Greenhaff “Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity”. So many great contributions! Add it to your reading list #myotwitter physoc.onlinelibrary.wiley.com/toc/14697793...

Special Issue: Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity: The Journal of Physiology: Vol 603, No 13

<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach @kevinmurachphd.bsky.social · Jul 30

😛

Kevin Murach @kevinmurachphd.bsky.social · Jul 28

“Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” @myoblue.bsky.social @pnasnexus.org academic.oup.com/pnasnexus/ad...

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle

Abstract. Muscle stem cells, or satellite cells, decline in number throughout the lifespan and may become senescent in very old age. Whether and how remain

academic.oup.com

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Kevin Murach @kevinmurachphd.bsky.social · Jul 25

“Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude” journals.physiology.org/doi/abs/10.1...

Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude | American Journal of Physiology-Cell Physiology | American Physiological Society

journals.physiology.org

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Kevin Murach @kevinmurachphd.bsky.social · Jun 7

A tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...

microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism

Metabolic flexibility refers to the ability of a tissue to adjust cellular fuel choice in response to conditional changes in metabolic demand and acti…

www.sciencedirect.com

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Reposted by Kevin Murach

Longhua Guo @longhuaguo.bsky.social · May 20

Rejuvenation in planarians. Check out the details in this link: www.nature.com/nataging?gcl... @nataging.nature.com

Nature Aging

How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the ...

www.nature.com

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Kevin Murach @kevinmurachphd.bsky.social · May 7

Nice!!!

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Reposted by Kevin Murach

Abigail Mackey @abigailmackey1.bsky.social · May 5

Our latest review is out now in @jphysiol.bsky.social

The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social

doi.org/10.1113/JP28...

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Kevin Murach @kevinmurachphd.bsky.social · Apr 27

Might have had to do with the age gap of the mice and/or the fiber type transition. We and others see growth in >4 month old C57s.

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Reposted by Kevin Murach

Dada Pisconti @dadapisconti.bsky.social · Apr 24

If you too are experiencing mental health issues due to the ongoing shitshow, please DM me or Signal me at ziadadina.19, I am trying to build a community to help each other.

Y'all, please repost and help me out, this is serious stuff

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Kevin Murach @kevinmurachphd.bsky.social · Apr 25

Myocellular adaptations to short-term weighted
wheel-running exercise are largely conserved during
C26-tumour induction in male and female mice #myoblue physoc.onlinelibrary.wiley.com/doi/epdf/10....

Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice

You have to enable JavaScript in your browser's settings in order to use the eReader.

physoc.onlinelibrary.wiley.com

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Kevin Murach @kevinmurachphd.bsky.social · Apr 23

Final Version: “A history of omics discoveries reveals the correlates and mechanisms of
loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young
investigator award invited review” #myoblue journals.physiology.org/doi/epdf/10....

A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review

journals.physiology.org

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Kevin Murach @kevinmurachphd.bsky.social · Apr 22

Seems to go along with recent work from @longhuaguo.bsky.social www.nature.com/articles/s43...

Aging, regeneration and whole-body rejuvenation in long-lived planarians - Nature Aging

We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotyp...

www.nature.com

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Kevin Murach @kevinmurachphd.bsky.social · Apr 22

Chambers et al. “At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle” #myoblue onlinelibrary.wiley.com/doi/full/10....

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...

onlinelibrary.wiley.com

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Kevin Murach @kevinmurachphd.bsky.social · Apr 13

Cool data here. We have some mouse data (regeneration, not amputation) that supports this! Stay tuned and great stuff @longhuaguo.bsky.social #myoblue @natureaging.bsky.social

Longhua Guo @longhuaguo.bsky.social · Apr 12

We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotypes were reversed to youthful states.

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Kevin Murach @kevinmurachphd.bsky.social · Apr 2

Thanks Dada! It was a nontrivial amount of work haha

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Kevin Murach @kevinmurachphd.bsky.social · Apr 2

Nice call. We can still fix it at proof stage!

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Kevin Murach @kevinmurachphd.bsky.social · Apr 2

This was a real labor of love: “A History of Omics Discoveries Reveals the Correlates and Mechanisms of Loading-Induced Hypertrophy in Adult Skeletal Muscle” w/Toby Chambers. #myoblue journals.physiology.org/doi/abs/10.1...

A History of Omics Discoveries Reveals the Correlates and Mechanisms of Loading-Induced Hypertrophy in Adult Skeletal Muscle | American Journal of Physiology-Cell Physiology | American Physiological S...

Since the early 2000s, omics approaches to study skeletal muscle hypertrophy consequent to loading (e.g. resistance exercise) have expanded dramatically. Beginning with genomics and transcriptomics, t...

journals.physiology.org

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