Keying ZHU
@keyinglia.bsky.social
Microglia~Myelin
Postdoc @UCSF (San Francisco)
PhD @Karolinska Institutet (Stockholm)
MSc @Fudan University (Shanghai)
Swedish Research Council (Vetenskapsrådet) Fellow
Postdoc @UCSF (San Francisco)
PhD @Karolinska Institutet (Stockholm)
MSc @Fudan University (Shanghai)
Swedish Research Council (Vetenskapsrådet) Fellow
Reposted by Keying ZHU
Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠
January 8, 2026 at 9:55 AM
Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠
Reposted by Keying ZHU
This paper represents a massive undertaking (6+ years!) led by then PhD student, now Postdoc Keying @keyinglia.bsky.social in collaboration with the Bob Harris lab and many amazing contributors. Thanks to everyone involved!
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January 2, 2026 at 10:16 AM
This paper represents a massive undertaking (6+ years!) led by then PhD student, now Postdoc Keying @keyinglia.bsky.social in collaboration with the Bob Harris lab and many amazing contributors. Thanks to everyone involved!
🧵3/3
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Reposted by Keying ZHU
Short summary
-Aging causes region-specific myelin degeneration in the spinal cord
-Microglia activate a protective TGFβ1 autocrine loop
-Disrupting microglial Tgfb1/Tgfbr2 leads to myelin loss and behavioral deficits that worsen with age
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-Aging causes region-specific myelin degeneration in the spinal cord
-Microglia activate a protective TGFβ1 autocrine loop
-Disrupting microglial Tgfb1/Tgfbr2 leads to myelin loss and behavioral deficits that worsen with age
🧵2/3
January 2, 2026 at 10:16 AM
Short summary
-Aging causes region-specific myelin degeneration in the spinal cord
-Microglia activate a protective TGFβ1 autocrine loop
-Disrupting microglial Tgfb1/Tgfbr2 leads to myelin loss and behavioral deficits that worsen with age
🧵2/3
-Aging causes region-specific myelin degeneration in the spinal cord
-Microglia activate a protective TGFβ1 autocrine loop
-Disrupting microglial Tgfb1/Tgfbr2 leads to myelin loss and behavioral deficits that worsen with age
🧵2/3
Reposted by Keying ZHU
Microglia checkpoints promote healthy myelin aging
Our new paper is out in Nature Neuroscience @natneuro.nature.com
www.nature.com/articles/s41...
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Our new paper is out in Nature Neuroscience @natneuro.nature.com
www.nature.com/articles/s41...
🧵1/3
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience
Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.
www.nature.com
January 2, 2026 at 10:16 AM
Microglia checkpoints promote healthy myelin aging
Our new paper is out in Nature Neuroscience @natneuro.nature.com
www.nature.com/articles/s41...
🧵1/3
Our new paper is out in Nature Neuroscience @natneuro.nature.com
www.nature.com/articles/s41...
🧵1/3