Kirti
LightNews LightNews
banner
kirtijn1.bsky.social
Kirti
@kirtijn1.bsky.social
26 followers 93 following 2 posts
Interested in studying gene regulation, use bacteria (in lab) to understand how regulation evolves (in nature),
| Microbiology | Bacterial Ecology | Decoding gene regulation with bacteria 🧬 | Want to learn how microbes will evolve to outlive us all 🦠💀
Posts Replies Media Videos
Reposted by Kirti
plosbiology.org
Mutations generate variation, critical for #evolution, but #MutationBias restricts the choice of mutation type. @deepaagashe.bsky.social &co use #Ecoli strains with different mutation biases to show that changing an old bias should yield more beneficial mutations @plosbiology.org 🧪 plos.io/46LjCRt
Schematic of the key prediction tested in this work. As the transversion (Tv) mutation bias of WT E. coli is shifted away from the ancestral bias, the resulting distribution of fitness effects (DFE) is predicted to change. Specifically, it should shift left with a bias reinforcement, with a lower fraction of beneficial mutations. In contrast, reversing the ancestral bias is predicted to cause right-shifted DFEs with higher proportions of beneficial mutations.
July 15, 2025 at 4:36 PM
Reposted by Kirti
istaresearch.bsky.social
Could gut microbes have evolved molecular clockwork just for antibiotic resistance?

Read more: ista.ac.at/en/news/cloc...

New paper by former ISTA postdoc Kirti Jain and Professor Calin Guet in @pnas.org.

#Antibiotics #AntibioticResistance #GeneRegulatoryNetwork #Ecoli #Homeostasis #Evolution
Pulsing genes and nuances in expression. Differences in the pulsatile expression of the mar system visualized in various engineered E. coli bacteria using fluorescence. © Guet group
April 10, 2025 at 1:05 PM
kirtijn1.bsky.social
doi.org/10.1073/pnas... Can basal (uninduced) gene expression play a role in fitness? I am excited to share findings from my postdoctoral project, where we investigated the basal expression of the mar operon—a key regulator of antibiotic resistance in enteric bacteria (E. coli) 1/2
Pulsatile basal gene expression as a fitness determinant in bacteria | PNAS
Active regulation of gene expression, orchestrated by complex interactions of activators and repressors at promoters, controls the fate of organism...
doi.org
April 8, 2025 at 12:47 PM