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Reposted by Kitty Murphy

Erin Sikorsky @erinsikorsky.bsky.social · 8d

Oof, one of my heroes.

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

www.nytimes.com

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Kitty Murphy @kittybmurphy.bsky.social · 16d

@evoldir.bsky.social

Reposted by Kitty Murphy

Seth Chagi (World of Paleoanthropology🏺) @sethchagi.bsky.social · 26d

🚨 WOPA needs a volunteer website admin! If you know WordPress & want to help keep paleoanthropology accessible, get in touch. DM/email for details. #volunteer #WordPress #Paleoanthropology

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Kitty Murphy @kittybmurphy.bsky.social · Sep 1

As someone who recently moved to Copenhagen to start a postdoc with @lauritsskov.bsky.social, I can highly recommend the city, the supervisor, and the research 🧬

Join us!

Laurits Skov @lauritsskov.bsky.social · Aug 28

Are you interested in doing a PhD in Copenhagen? Interested in studying Neanderthals and Denisovans which live on in our genomes?
Than you are more than welcome to apply to join my group starting Jan 2026 :)

candidate.hr-manager.net/ApplicationI...

Please reach out if you have any questions!

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Kitty Murphy @kittybmurphy.bsky.social · Jul 29

Computational biologists, sign up! 👩‍💻🧑‍💻

Don’t miss out on the chance to share your work and exchange ideas. Abstract deadline: 12th August

See you there 🤓

londonomics.bsky.social @londonomics.bsky.social · Jul 29

Are you an Early Career Researcher in bioinformatics? Then this symposium is for you 💡

Join us for a day of talks, networking and career discussions. Present your work to get fresh new ideas and the chance to win prizes 💸

Featuring @avsecz.bsky.social of Google DeepMind as our keynote speaker⚡️

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Kitty Murphy @kittybmurphy.bsky.social · Jun 5

Super excited to see them at Glastonbury this year! 🎪

Kitty Murphy @kittybmurphy.bsky.social · Jun 2

Londonomics is back with its second workshop of the year: computer science for bioinformaticians 💡

4 pm @ UCL, with a pizza and drinks social after for an opportunity to network with fellow computational ECRs dotted around London ⚡️

londonomics.bsky.social @londonomics.bsky.social · Jun 2

Join us today for a workshop on computer science for Bioinformaticians! 🧑‍💻👩‍💻👨‍💻

More info and tickets (only a few left!) here: www.eventbrite.com/e/londonomic...

Londonomics presents: Computer Science for Bioinformaticians

The second in a series of Londonomics workshops for early-career computational researchers in London, with Mithun Srinavaratnarajah.

www.eventbrite.com

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Kitty Murphy @kittybmurphy.bsky.social · May 28

This was a true team effort, and huge thanks go to everyone involved: @sj-marzi.bsky.social, Di Hu, @bartdestrooper.bsky.social, @mancusorenzo.bsky.social, Leen Wolfs, @susanrohde.bsky.social, Gonzalo Leguía Fauró, and Ivana Geric ✨

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Kitty Murphy @kittybmurphy.bsky.social · May 28

Lastly, we were excited to find that regions with increased chromatin accessibility in APOE2 microglia were enriched for vitamin D receptor binding, suggesting vitamin D signalling as a potential protective mechanism and therapeutic avenue.

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Kitty Murphy @kittybmurphy.bsky.social · May 28

Comparison with independent studies showed that APOE2 microglia were enriched for plaque-phagocytosing genes, prompting us to test their phagocytic activity. Using E. coli and myelin, we found that they were indeed more phagocytic than APOE4 microglia.

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Kitty Murphy @kittybmurphy.bsky.social · May 28

Genes downregulated in APOE4-expressing microglia were enriched in putatively protective microglial states, suggesting a failure to transition into these states.

Additionally, cytokine expression was elevated, consistent with previous findings in mouse microglia expressing APOE4.

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Kitty Murphy @kittybmurphy.bsky.social · May 28

We observed consistent differences in gene expression and chromatin accessibility. For example, the cellular migration-related gene CHCHD2 showed higher expression and increased chromatin accessibility near its transcription start site in APOE2 microglia.

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Kitty Murphy @kittybmurphy.bsky.social · May 28

As anticipated, the most pronounced differences were observed between APOE4 (risk-increasing in some populations) and APOE2 (protective).

Expression changes were partly driven by loss of function, but only genes downregulated in APOE4 and KO microglia were enriched for AD risk variants.

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Kitty Murphy @kittybmurphy.bsky.social · May 28

Excited to share that a chapter of my PhD has just been published in Nature Communications!

We profiled the transcriptomic and chromatin landscapes of microglia expressing the different APOE variants, which were xenografted into the brains of an Alzheimer's disease (AD) mouse model 🧠🧬

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Kitty Murphy @kittybmurphy.bsky.social · May 15

And just like that, 5 years in the Marzi lab @sj-marzi.bsky.social have come to an end. Couldn’t have asked for a better team ✨

Super excited to say, I’m switching fields and will be working with ancient human genomes in the Skov lab @lauritsskov.bsky.social in Copenhagen 🇩🇰

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Kitty Murphy @kittybmurphy.bsky.social · Apr 29

Excited to see a part of my PhD work out in the 🌍

We developed CHAS using 🧠 acetylation profiles, but it can be extended! Would love to hear from you if you try it with other tissues and cell types 🫁 🩸🫀

Lucky to have worked on this with an excellent team, more details below 👇🏻

Sarah Marzi @sj-marzi.bsky.social · Apr 28

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders".

www.cell.com/cell-reports...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders

Murphy et al. develop CHAS, a computational tool that uncovers cell type-specific patterns in bulk tissue histone acetylation data. Applying CHAS to brain disorders reveals distinct cell type targets ...

www.cell.com

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Reposted by Kitty Murphy

Maxim Greenberg @maxvcg.bsky.social · Apr 4

This is a devastating and essential read. Here is a gift link for those without subs. The part about outside perceptions of scientists compared with almost a blue-collar reality is spot on (without even mentioning meager salaries). www.nytimes.com/2025/04/03/o...

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Kitty Murphy @kittybmurphy.bsky.social · Apr 2

Londonomics is back! ⚡️

Join us next Thursday 4pm @ The Francis Crick Institute.

Don’t sleep on this - only one ticket left!

londonomics.bsky.social @londonomics.bsky.social · Apr 2

We’re excited to bring you a series of talks and workshops 💥

Kicking things off with all things single-cell analysis with Dr @kristinaulicna.bsky.social 👩‍💻 🧬

More info and FREE tickets (only 1 left!) here: www.eventbrite.com/e/londonomic...

Talk followed by a networking social 🍕

Londonomics presents: Single-cell analysis with Dr Kristina Ulicna

The first of a series of Londonomics workshops for early-career computational researchers in London. This month, single-cell analysis!

www.eventbrite.com

Reposted by Kitty Murphy

londonomics.bsky.social @londonomics.bsky.social · Apr 2

We’re excited to bring you a series of talks and workshops 💥

Kicking things off with all things single-cell analysis with Dr @kristinaulicna.bsky.social 👩‍💻 🧬

More info and FREE tickets (only 1 left!) here: www.eventbrite.com/e/londonomic...

Talk followed by a networking social 🍕

Londonomics presents: Single-cell analysis with Dr Kristina Ulicna

The first of a series of Londonomics workshops for early-career computational researchers in London. This month, single-cell analysis!

www.eventbrite.com

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Reposted by Kitty Murphy

Cathryn Lewis @cathrynlewis.bsky.social · Mar 27

📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...

Picture of Cathryn Lewis' research group at the SGDP Centre, waving and smiling.

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Reposted by Kitty Murphy

openRxiv @openrxiv.bsky.social · Mar 11

openRxiv has arrived!

We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...

#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

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Kitty Murphy @kittybmurphy.bsky.social · Mar 7

What a line-up! Just in time for international women’s day 💫 congrats!

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Reposted by Kitty Murphy

Chris Stringer @chrisbstringer.bsky.social · Feb 27

Comparative characterization of human accelerated regions in neurons [including brain evolution] www.nature.com/articles/s41...

Comparative characterization of human accelerated regions in neurons - Nature

The cis-regulatory functions of human accelerated regions of genomic loci and their potential contribution to human brain evolution are revealed.

www.nature.com

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Kitty Murphy @kittybmurphy.bsky.social · Feb 22

Thanks to the discovery of sodium channels and experiments in giant squid 🦑 and much more in between, we now have a non-addictive pain treatment 💊

Brilliant storytelling of why long term funding of basic science across disciplines is critical.

Jeremy Berg @jeremymberg.bsky.social · Feb 22

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.

This helps me remember what this is all about.

Ironically, it is about the treatment of pain.

the word irony is written on a white background

ALT: the word irony is written on a white background

media.tenor.com

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Kitty Murphy @kittybmurphy.bsky.social · Feb 22

I was part of the Marzi lab for my masters, PhD, and now postdoc. @sj-marzi.bsky.social is an enthusiastic scientist and supportive mentor. The science is cool and the people are even cooler. Can’t recommend enough!!! 🤓

Apply apply apply 👇🏻

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