Julie la Cour Karottki, PhD.
kjlck.bsky.social
Julie la Cour Karottki, PhD.
@kjlck.bsky.social
Biotechnologist.
Reposted by Julie la Cour Karottki, PhD.
There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
Reposted by Julie la Cour Karottki, PhD.
After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!

www.nature.com/articles/s42...

#science #biotech #cancermetabolism
Thread below:
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism
Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...
www.nature.com
January 20, 2025 at 9:41 AM
Reposted by Julie la Cour Karottki, PhD.
I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...
January 14, 2025 at 3:05 PM