Kyle MacLea 🦠
@kmaclea.bsky.social
1.4K followers 1.5K following 110 posts
I study microbes (#Bacteria, #Phages) but love the whole #TreeOfLife @UofNH @UNHManchester associate professor #MicrobialGenomics #ScienceEd (he/him/his)
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Reposted by Kyle MacLea 🦠
evgenii-protasov.bsky.social
Polysaccharide-degrading archaea dominate acidic hot springs: genomic and cultivation insights into a novel Thermoproteota lineage
Candidatus Marsarchaeota is now isolated and renamed as Tardisphaerales (phylum Thermoproteota) 🤓
@asm.org
journals.asm.org/doi/10.1128/...
kmaclea.bsky.social
Is there an Omaha of the Rockies or something? :) That circle for Omaha (if Nebraska) seems way far west, unless it’s not to scale.
Reposted by Kyle MacLea 🦠
ryanmarino.bsky.social
~40% of Hepatitis B infections are caught in childhood. It is contagious enough that it can be spread just from sharing common household objects.

The chance of chronic infection (ie does not clear, and is associated with high rates of liver failure and cancer) ranges from 50%-90% in this age group.
Reposted by Kyle MacLea 🦠
quantamagazine.bsky.social
Lokiarchaea are tricky to work with in the lab: they grow very slowly, exclusively in an oxygen free environment with the presence of symbiotic bacteria. But with careful nurturing, scientists hope to witness their cell division at work.
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
www.quantamagazine.org
kmaclea.bsky.social
Sometimes I find myself in some kind of teaching fugue State where the metaphors and analogies come fast and furious too! Sometimes I feel like I could never really capture all of those a second time!
Reposted by Kyle MacLea 🦠
jimshaw.bsky.social
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!

Nanopore's getting accurate, but

1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?

with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social

1 / N
biorxiv-bioinfo.bsky.social
High-resolution metagenome assembly for modern long reads with myloasm https://www.biorxiv.org/content/10.1101/2025.09.05.674543v1
Reposted by Kyle MacLea 🦠
jomcinerney.bsky.social
Extraordinary paper. I LOVE this sentence:

“This translates to a net lateral gene transfer rate of ~250 genes L−1 seawater day−1 and involves both “flexible” and “core” genes. “

Must read in detail, but these numbers are amazing. academic.oup.com/ismej/advanc...
Net rate of lateral gene transfer in marine prokaryoplankton
Abstract. Lateral gene transfer is a major evolutionary process in Bacteria and Archaea. Despite its importance, lateral gene transfer quantification in na
academic.oup.com
Reposted by Kyle MacLea 🦠
andrewjroger.bsky.social
I gave a symposium talk at the European Society for Evolutionary Biology 2025 (#eseb2025) meeting last week and this was my title slide showcasing how I was speaking as an independent scientist because @dalhousieu.bsky.social @dalhousie.bsky.social has locked us out.
Reposted by Kyle MacLea 🦠
nizet.bsky.social
Saddened to learn of the passing of Moselio "Elio" Schaechter—Distinguished Professor at Tufts, SDSU and UCSD—humanist and visionary leader in the fields of microbiology and scientific communication—mentor, friend, and inspiration to me and so many others

Small Things Considered
Big Things Achieved
Reposted by Kyle MacLea 🦠
davidimiller.bsky.social
🧪 Update: NSF will *appeal* an earlier court order that blocked 15% indirect rates.

I'm mostly surprised it took this long for them to file an appeal. So the fight continues. See: storage.courtlistener.com/recap/gov.us...

Article from June as context: www.insidehighered.com/news/quick-t...
storage.courtlistener.com
Reposted by Kyle MacLea 🦠
jacquelyngill.bsky.social
Do you love alpine plants, ancient DNA, and/or population genetics? My lab will be hiring a postdoc soon to be based at the University of Maine! We’re looking for someone who uses genetic tools and thinks like a community ecologist. Happy to chat at #ESA2025 if you’re interested.
Reposted by Kyle MacLea 🦠
michalis-averof.bsky.social
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
Reposted by Kyle MacLea 🦠
philplait.bsky.social
W
T
A
F

This country is a joke. A very, very terrible joke.
joshgerstein.bsky.social
JUST IN: Senate confirms Jeanine Pirro as US Atty for DC, 50-45
kmaclea.bsky.social
History of the English Language was fascinating. Intro to Linguistics too!
Reposted by Kyle MacLea 🦠
laurahelmuth.bsky.social
Bacteria from a Yellowstone hot spring do something no other organism has been found to do: breathe oxygen and sulfur at the same time. 🧪 It's both aerobic and anaerobic, a beautiful freaky creature from a beautiful freaky place
The Cells That Breathe Two Ways | Quanta Magazine
In a hot spring at Yellowstone National Park, a microbe does something that life shouldn’t be able to do: It breathes oxygen and sulfur at the same time.
www.quantamagazine.org
Reposted by Kyle MacLea 🦠
audeber.bsky.social
🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...
www.science.org
Reposted by Kyle MacLea 🦠
katelynburns.com
it's never been about antisemitism
atrupar.com
Linda McMahon on Columbia settlement: "This is a monumental victory for conservatives who wanted to do things on these elite campuses for a long time because we had such far left-leaning professors."
kmaclea.bsky.social
Once as postdoc/lab manager I asked the PI for help with setting the large floor centrifuge that I hadn’t used before. He set the rotor wrong and sheared off the pins, and centrifuge was out of commission for months. VERY glad it wasn’t me! 😅
kmaclea.bsky.social
Very cool! One of my last pups was very picky as he got older and this would have been helpful I think!
kmaclea.bsky.social
Wow didn’t know this kind of stuff existed for dogs!
Reposted by Kyle MacLea 🦠
gretchentg.bsky.social
Terrible Friday news dump.The wealth of expertise. The decades of scientific progress. The emerging and urgent challenges we were focused on tackling. It is all so short-sided and cruel. www.nytimes.com/2025/07/18/c...
E.P.A. Says It Will Eliminate Its Scientific Research Arm
www.nytimes.com
Reposted by Kyle MacLea 🦠
nizet.bsky.social
M⃣I⃣S⃣S⃣I⃣N⃣G⃣ L⃣I⃣N⃣K⃣S⃣

𝙉𝙖𝙩𝙪𝙧𝙚 paper by Sikora et al: metagenomic data from 1,313 ancient human remains over 37,000 years

Identified >3,000 instances of known human pathogens

Zoonotic pathogens begin to appear ~6,500 years ago coinciding with the rise of livestock domestication—major epidemiological shift
The spatiotemporal distribution of human pathogens in ancient Eurasia - Nature
Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and zoonotic pathogens coi...
www.nature.com