生物のすべての細胞は、代謝活動をするのに「酸素」を必要としています。特に、脳の細胞のエネルギー要求は高いので、脳内でどのように酸素が分布するかに従って、脳内での情報処理の特性、こころのあり様が大きく影響を受けることが予想されます。
www.felixbeinlich.de

これまで、生体組織での酸素をイメージングすることは困難でしたが、Felix Beinlich 先生らは、新たなテクノロジーを開発して、生きているマウスの脳内酸素イメージングに成功しました（Beinlich et al., Science 2024）。
www.science.org/doi/10.1126/...

東北大学 大学院生命科学研究科 超回路脳機能分野
松井広教授研究室
www.ims.med.tohoku.ac.jp/matsui/

Furukawa K, Ikoma Y, Niino Y, Hiraoka Y, Tanaka K, Miyawaki A, Hirrlinger J, Matsui K (2025) Dynamics of neuronal and astrocytic energy molecules in epilepsy. Journal of Neurochemistry, 169: e70044.
doi.org/10.1111/jnc....
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The brain process information efficiently with far less energy compared to computers. This study aimed to elucidate the mechanisms that regulate metabolic energy dynamics and deepen our understanding of the systems that support biological information processing.
www.ims.med.tohoku.ac.jp/matsui/

With repeated hippocampal stimulation, seizures intensify. Interestingly, while the reduction in ATP levels decreased, an increase in blood volume increase was observed. This rise in metabolic energy supply may partially compensate for the loss of ATP in neurons.
doi.org/10.1111/jnc....

The duration of epileptic neuronal hyperactivity varied in the same animals. However, the reduction in intracellular neuronal ATP remained constant, suggesting that the varying degree of ATP consumption during neuronal hyperactivity has little impact on net ATP levels.
doi.org/10.1111/jnc....

The brain was subjected to an epileptic metabolic load. During an epileptic seizure, pyruvate levels in astrocytes increased, while ATP levels in neurons decreased. The transfer of metabolic energy molecules may be temporarily disrupted during an epileptic episode.
doi.org/10.1111/jnc....

Furukawa K, Ikoma Y, Niino Y, Hiraoka Y, Tanaka K, Miyawaki A, Hirrlinger J, Matsui K (2025) Dynamics of neuronal and astrocytic energy molecules in epilepsy. Journal of Neurochemistry, 169: e70044.
doi.org/10.1111/jnc....
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