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koolchemistry.bsky.social @koolchemistry.bsky.social · 10d

Using a DNA-catalyst conjugate to place aryl groups at specific sequences in RNA -
Congrats to Sumon Pratihar for leading the work!

doi.org/10.1002/anie.202515681

Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates

DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence-speci...

doi.org

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koolchemistry.bsky.social @koolchemistry.bsky.social · Sep 5

New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method

Great work by Linglan Fang and Wenrui Zhong in our lab!

doi.org/10.1021/jacs.5c11900

Localized 2′-OH Acylation at Poly(A) Extends RNA Translation

The potential of coding RNAs as a general therapeutic modality is limited by their short intracellular lifetime. Here, we investigate the effects of localized post-transcriptional RNA modification on ...

doi.org

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koolchemistry.bsky.social @koolchemistry.bsky.social · Mar 26

Peter was a huge influence on me - he made it cool to combine organic chem and nucleic acids. I was lucky to have him as a postdoc mentor

koolchemistry.bsky.social @koolchemistry.bsky.social · Mar 26

Spoke at Monday's ACS symposium in honor of Peter Dervan's birthday - it was a great time seeing Peter, Jackie, and the many alums who he trained

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koolchemistry.bsky.social @koolchemistry.bsky.social · Feb 2

thanks also to our collaborators in the Ford Lab!

Long term goal is to activate DNA repair to suppress mutagenesis...

koolchemistry.bsky.social @koolchemistry.bsky.social · Feb 2

Congratulations to Yixuan (Edward) Gao for publication of his paper on the first SMUG1 small molecule activator - it upregulates pyrimidine repair in cellular models. doi.org/10.1016/j.dnarep.2025.103809