Korostelev Lab
@korostelevlab.bsky.social
We are interested in life sciences, structural biology, translation, ribosomes, neurobiology and RNA therapeutics.
Location: RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA
https://www.umassmed.edu/korostelev-lab/
Location: RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA
https://www.umassmed.edu/korostelev-lab/
ROOL monomers entangle with other monomers via strand swapping to form octameric RNA nanocages.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 16, 2025 at 6:03 PM
ROOL monomers entangle with other monomers via strand swapping to form octameric RNA nanocages.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
With our @RTI-UMassChan.bsky.social colleagues Xiaobin Ling and Wenwen Fang, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 16, 2025 at 6:01 PM
With our @RTI-UMassChan.bsky.social colleagues Xiaobin Ling and Wenwen Fang, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How do Dicer-1 and Loqs-PB make miRNA?
We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00853-X
Fun collab. with @zamore_lab and Traci Hall...
We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00853-X
Fun collab. with @zamore_lab and Traci Hall...
November 24, 2024 at 6:16 PM
How do Dicer-1 and Loqs-PB make miRNA?
We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00853-X
Fun collab. with @zamore_lab and Traci Hall...
We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00853-X
Fun collab. with @zamore_lab and Traci Hall...
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
November 24, 2024 at 6:16 PM
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9