Kevin Coombes
@krc77.bsky.social
Husband, father, grandfather, cyclist, tifoso, mathematician, biostatistician, bioinformatician. Reader of books, watcher of movies, listener to music, wanderer through museums. Appreciator of foreign travel.
How much credit do I get for: Stuey O'Grady, Simon Gerrans, Richie Porte, and Daryl Impey?
January 17, 2026 at 1:35 PM
How much credit do I get for: Stuey O'Grady, Simon Gerrans, Richie Porte, and Daryl Impey?
From Pairwise Distances to Neighborhood Preservation: Benchmarking Dimensionality Reduction Algorithms for CyTOF, scRNA-seq, and CITE-seq | bioRxiv share.google/qdnPleqsl5B0...
We're in the middle of revising this to respond to the first round of reviewer comments.
We're in the middle of revising this to respond to the first round of reviewer comments.
From Pairwise Distances to Neighborhood Preservation: Benchmarking Dimensionality Reduction Algorithms for CyTOF, scRNA-seq, and CITE-seq
Dimensionality reduction algorithms are essential tools for visualizing high-dimensional biological data, such as single-cell transcriptomics, mass cytometry by time of flight, and cellular indexing o...
share.google
January 9, 2026 at 4:35 PM
From Pairwise Distances to Neighborhood Preservation: Benchmarking Dimensionality Reduction Algorithms for CyTOF, scRNA-seq, and CITE-seq | bioRxiv share.google/qdnPleqsl5B0...
We're in the middle of revising this to respond to the first round of reviewer comments.
We're in the middle of revising this to respond to the first round of reviewer comments.
Wait. I thought Ernesto Colnago was the most famous bike mechanic in history. And Eddy Merckx might back me up on that claim.
January 7, 2026 at 3:52 AM
Wait. I thought Ernesto Colnago was the most famous bike mechanic in history. And Eddy Merckx might back me up on that claim.
Just yesterday. I figured out that 18 year olds were born in 2008. Which, of course, makes no sense, since as far as I can tell, 2008 is indistinguishable from yesterday.
January 7, 2026 at 3:40 AM
Just yesterday. I figured out that 18 year olds were born in 2008. Which, of course, makes no sense, since as far as I can tell, 2008 is indistinguishable from yesterday.
Has he told UAE that?
January 6, 2026 at 6:15 PM
Has he told UAE that?
Repeat after me: There is no bottom.
January 6, 2026 at 3:50 AM
Repeat after me: There is no bottom.
How did survivors describe tornados before there were freight trains?
January 6, 2026 at 3:48 AM
How did survivors describe tornados before there were freight trains?
What does it say about the sport that two of your five "future GT winners" are on UAE (home of the most successful current GT winner), and a third just left that team to get more opportunities?
January 1, 2026 at 12:45 PM
What does it say about the sport that two of your five "future GT winners" are on UAE (home of the most successful current GT winner), and a third just left that team to get more opportunities?
In the USA, cycling fans have hardly ever been able to watch free, live cycling. Decades ago, all we saw was four Sundays of highlights of the TdF on ABC. In the Armstrong era, we got free daily coverage of TdF. Now I can cobble together 3 paid subscriptions to cover the season. Until HBO/MAX dies.
December 27, 2025 at 1:20 PM
In the USA, cycling fans have hardly ever been able to watch free, live cycling. Decades ago, all we saw was four Sundays of highlights of the TdF on ABC. In the Armstrong era, we got free daily coverage of TdF. Now I can cobble together 3 paid subscriptions to cover the season. Until HBO/MAX dies.
Yes; Gianni Savio would be out there hustling full time to sell the rights to fill in those empty spaces.
December 23, 2025 at 12:16 PM
Yes; Gianni Savio would be out there hustling full time to sell the rights to fill in those empty spaces.
Actually, they look exactly like the chocolate sambuca cookie/biscuit recipe from the Gourmet Coolbook. I do hope you included the sambuca.
December 14, 2025 at 1:17 AM
Actually, they look exactly like the chocolate sambuca cookie/biscuit recipe from the Gourmet Coolbook. I do hope you included the sambuca.
My favorite cycling story about long_time managers, sponsors, and loyalty is 2010-2011 as JRB hunted new sponsors, team almost folded, until Europcar came along requiring Thomas Voeckler to stay. So Tommy turned down a big salary increase to save the team. Then wore yellow at the TdF for 11 days
November 21, 2025 at 12:45 PM
My favorite cycling story about long_time managers, sponsors, and loyalty is 2010-2011 as JRB hunted new sponsors, team almost folded, until Europcar came along requiring Thomas Voeckler to stay. So Tommy turned down a big salary increase to save the team. Then wore yellow at the TdF for 11 days
Sometimes you can manipulate the data frame to write the fomula as "Y ~ .". Then fit the model and extract the formula from the result.
November 17, 2025 at 12:19 PM
Sometimes you can manipulate the data frame to write the fomula as "Y ~ .". Then fit the model and extract the formula from the result.
"We've always been at war with Eurasia."
November 15, 2025 at 11:12 AM
"We've always been at war with Eurasia."
Or they steer healthier patients to trials A and sicker patients to trial B. Drug A succeeds; drug B fails. But they may be equivalent
November 11, 2025 at 12:11 PM
Or they steer healthier patients to trials A and sicker patients to trial B. Drug A succeeds; drug B fails. But they may be equivalent
Imagine two trials. Same inclusion/exclusion. Drugs with different mechanisms. MDs steer patients to different trials based on information not formally assessed in the trials. I can imagine both trials getting better results than would hold in the general population defined by inc/exc.
November 11, 2025 at 12:09 PM
Imagine two trials. Same inclusion/exclusion. Drugs with different mechanisms. MDs steer patients to different trials based on information not formally assessed in the trials. I can imagine both trials getting better results than would hold in the general population defined by inc/exc.
What caught my eye in your excerpt was the idea of physicians picking the trial patients. I noticed at both MDACC and OSU James that disease groups always had multiple trials running. Patients eligible for multiple trials weren't offered all of them. How does this affect RCT assumptions or analysis?
November 9, 2025 at 10:53 PM
What caught my eye in your excerpt was the idea of physicians picking the trial patients. I noticed at both MDACC and OSU James that disease groups always had multiple trials running. Patients eligible for multiple trials weren't offered all of them. How does this affect RCT assumptions or analysis?
Well, actually, those are LLMs, which are merely the latest impersonators of AI.
November 6, 2025 at 10:50 AM
Well, actually, those are LLMs, which are merely the latest impersonators of AI.
D'you think they ever considered hyphenating their last names?
November 4, 2025 at 12:47 PM
D'you think they ever considered hyphenating their last names?
I've been trying to keep the code for ny papers in GitLab projects for a long time. Probably since Keith Baggerly and I started pointing out the flaws in the Potti-Nevins series of papers from Duke in around 2008. How "historical" can papers be to be posted to the papers-with-code feed?
November 3, 2025 at 3:33 PM
I've been trying to keep the code for ny papers in GitLab projects for a long time. Probably since Keith Baggerly and I started pointing out the flaws in the Potti-Nevins series of papers from Duke in around 2008. How "historical" can papers be to be posted to the papers-with-code feed?
A man after my own heart. I've been fighting this battle with trainees for decades. Also trying to convince them that active voice is better than passive. "Analyses were performed...".
November 3, 2025 at 11:49 AM
A man after my own heart. I've been fighting this battle with trainees for decades. Also trying to convince them that active voice is better than passive. "Analyses were performed...".
The chart shown already subtracted Pogi's points from UAE. They actually have 40,802 total for the year.
October 23, 2025 at 10:02 AM
The chart shown already subtracted Pogi's points from UAE. They actually have 40,802 total for the year.
Perhaps more importantly, if you took Pogačar's points away to create a new (virtual, one-man) team, then UAE would still be number one.
October 22, 2025 at 12:11 PM
Perhaps more importantly, if you took Pogačar's points away to create a new (virtual, one-man) team, then UAE would still be number one.
Is there something magical about a 60-year anniversary?
October 20, 2025 at 1:20 AM
Is there something magical about a 60-year anniversary?