Our growing team at @uchicagocancer.bsky.social is building on these concepts, with the goal of translating this knowledge to improved therapies for metastatic cancers. More to come! (4/4)

Huge thanks to everyone who contributed to this team effort #LoweLabMSKCC #LabMassague @danapeer.bsky.social #ChristineIacobuzio #CPCRMSK @ronanchaligne.bsky.social #SAIL #RichardKoche #ERIL, and key funding support from #NCI @jcchildsfund.bsky.social #KatzmanFellowship #GMTEC! (3/4)

As mechanism, we identify distinct epigenomic states that are favored by different metastatic organs and begin to emerge even in premalignant cells. This may be a broader principle w/ implications for the interpretation of tumor genetics & therapeutic targeting of metastatic disease. (2/4)

🚨Location, location, location! Now out @natcancer.nature.com, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation as in pancreatic cancer as a clinically relevant example: nature.com/articles/s43.... (1/4)

Thank you! Yes, I think I am overdue to renew so that is a good reminder.

Me too! New PI, laser-focused on metastasis (and just getting started on bluesky...) 🙂

Congratulations, Julio!

Thank you so much for all your support, Dana!! Just starting on bluesky -- apologies for the delay... And greetings from Chicago! 🙂

Thanks so much!! Just starting on bluesky -- apologies for the delay... And greetings from Chicago! 🙂