Kathleen Watt
@kwattever.bsky.social
Postdoctoral fellow at Karolinska Institutet / Queen's University | Cancer plasticity, mRNA translation, and all things 5'UTR
Reposted by Kathleen Watt
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
bit.ly
November 16, 2025 at 8:23 AM
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
Reposted by Kathleen Watt
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
www.nature.com
October 16, 2025 at 9:47 PM
Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...