labthoma.bsky.social
Thomä lab
@labthoma.bsky.social
290 followers 140 following 3 posts
We are a structural biology lab located both at EPFL in Lausanne and at the Friedrich Miescher Institute in Basel. thomalab.org www.epfl.ch/labs/upthomae
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fmiscience.bsky.social
FMI science @fmiscience.bsky.social · Jul 31
Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...
How DNA packaging controls the “genome’s guardian”
Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...
www.fmi.ch
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labthoma.bsky.social
Thomä lab @labthoma.bsky.social · Jul 31
Stay tuned for @csandate.bsky.social's thread to come!
@deyasinic.bsky.social
Thanks for all the support! #EPFL @fmiscience.bsky.social @erc.europa.eu @snsf.ch @krebsliga.bsky.social
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labthoma.bsky.social
Thomä lab @labthoma.bsky.social · Jul 31
Congrats to all the authors on our latest work! We reveal how p53 interacts with chromatin and show, via ubiquitin-related factors USP7 and E6-E6AP, that only specific cofactors can co-reside on nucleosomes together with p53.
tinyurl.com/2feuezvj
@csandate.bsky.social
@deyasinic.bsky.social
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labthoma.bsky.social
Thomä lab @labthoma.bsky.social · May 8
📝 🚨 Review alert from the Thomä Lab

@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky
Primed for degradation: How weak protein interactions enable molecular glue degraders
Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…
tinyurl.com
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