LabVogeli
@labvogeli.bsky.social
NMR spectroscopy for the elucidation of conformation and communication networks within and between proteins and nucleic acids. University of Colorado, USA
Reposted by LabVogeli
We uncover the first evidence that the long-mysterious Zβ domain of #ADAR1 binds G-quads, a surprising twist that reshapes how we think about ADAR targeting—opening new directions for understanding the links between innate immunity and splicing regulation. #NMR #RNA
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Zα and Zβ domains of ADAR1 and ZBP1 bind to G-quadruplexes with low micromolar affinity
While it is well established that the Zα domains of ADAR1 and ZBP1 proteins bind Z-form prone nucleic acid, it has also been shown that the Zα domain of ADAR1 binds DNA G-quadruplexes. However, no bin...
www.biorxiv.org
November 20, 2025 at 5:33 PM
We uncover the first evidence that the long-mysterious Zβ domain of #ADAR1 binds G-quads, a surprising twist that reshapes how we think about ADAR targeting—opening new directions for understanding the links between innate immunity and splicing regulation. #NMR #RNA
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...