laklab.bsky.social
Armin Lak
@laklab.bsky.social
1.4K followers 810 following 44 posts
Neuroscientist investigating neuronal bases of reward and learning. Associate Prof at Oxford University. www.laklab.org
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 11
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
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Reposted by Armin Lak
lhuntneuro.bsky.social
Laurence Hunt @lhuntneuro.bsky.social · 13d
Looking for a PhD next year? Want to come and work on the next generation of OPM-MEG/EEG biomarkers in computational psychiatry?

Apply for our MRC iCase studentship with @mkflugge.bsky.social, collabs with @lilweb.bsky.social + industrial placement at P1Vital:
www.medsci.ox.ac.uk/study/gradua...
Development of robust, single-subject markers of predictive inference for computational psychiatry
www.medsci.ox.ac.uk
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laklab.bsky.social
Armin Lak @laklab.bsky.social · 19d
Beautiful and clear results showing that temporal difference error calculation is hardwired in the dopamine/striatum mircocircuits: www.biorxiv.org/content/10.1...
from @malcolmgcampbell.bsky.social and @naoshigeuchida.bsky.social
A hardwired neural circuit for temporal difference learning
The neurotransmitter dopamine plays a major role in learning by acting as a teaching signal to update the brain's predictions about rewards. A leading theory proposes that this process is analogous to...
www.biorxiv.org
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Reposted by Armin Lak
cmc-lab.bsky.social
CMC lab @cmc-lab.bsky.social · 21d
In our Learning Club @cmc-lab.bsky.social today (Aug 18, Thu, 2pm CET), Samuel Liebana will tell us about his paper (www.cell.com/cell/fulltex... [joint work w/ @saxelab.bsky.social & @laklab.bsky.social]. Want to attend, send an empty email to [email protected] to get the link!
www.cell.com
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laklab.bsky.social
Armin Lak @laklab.bsky.social · 29d
Concise and informative highlight on our recent paper, thanks to Seung Chan Kim, Sehwan Kim & Sang Ryong Kim. www.nature.com/articles/s41...
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Reposted by Armin Lak
andrewtanyongyi.bsky.social
Andrew Tan @andrewtanyongyi.bsky.social · Aug 17
Hagai Bergman - whose celebrated work was a critical step in identifying the subthalamic nucleus as a target for deep brain stimulation in Parkinson's disease - & Josh Goldberg, both of the Hebrew University of Jerusalem, helping to stop traffic (posted by Josh on X): Stop the war! Bring them home!
From https://x.com/GoldbergLab/status/1956980620124475611
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Reposted by Armin Lak
peterkok.bsky.social
Peter Kok @peterkok.bsky.social · Aug 8
We are recruiting a new PI at the FIL @imagingneuroucl.bsky.social, Associate or Full Professor. This is an amazing place to do cognitive neuroscience, in the heart of London. If you or someone you know might be interested, please pass it on. #neuroskyence

www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
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Reposted by Armin Lak
alexkwan.bsky.social
Alex Kwan @alexkwan.bsky.social · Aug 7
New preprint + thread 🧵

#Psychedelics induce the formation of new synapses, but where do they connect?

Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.

www.biorxiv.org/content/10.1...

1/12
Summary figure for study of psilocybin's effect on cortical network connectivity.
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Reposted by Armin Lak
melgaby.bsky.social
Mohamady El-Gaby @melgaby.bsky.social · Aug 7
Can we use what we’ve learned about cognitive maps to understand social cognition, including theory of mind?
If you’re interested in answering this question then this is a fantastic postdoc opportunity with @mkwittmann.bsky.social in collaboration with @summerfieldlab.bsky.social and my lab.
mkwittmann.bsky.social
Marco K Wittmann @mkwittmann.bsky.social · Aug 7
📢 Job announcement: Two (!) 3-year postdoc jobs in our lab at UCL 📢

🧠💫🔊 We are looking for postdocs interested in the abstract mechanisms underlying social cognition. Modelling, fMRI and non-invasive ultrasound, a new deep-brain stimulation method.

Please RT

www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
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Reposted by Armin Lak
malcolmgcampbell.bsky.social
Malcolm Campbell @malcolmgcampbell.bsky.social · Aug 7
Our paper on foraging is now published in Neuron! Read it here:

www.cell.com/neuron/fullt...

This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics
Bukwich and Campbell et al. show that mice integrate elapsed time and reward intake, scaled by a latent patience variable, to decide when to leave virtual “patches.” Frontal cortex ramping activity ma...
www.cell.com
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Reposted by Armin Lak
guidomeijer.com
Guido Meijer @guidomeijer.com · Aug 5
🚨Pre-print alert🚨

We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭

How is this possible? Strap in! (1/9) 👇🧵

doi.org/10.1101/2025...
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
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Reposted by Armin Lak
ilanawitten.bsky.social
Ilana Witten @ilanawitten.bsky.social · Aug 5
We're looking for a research assistant to work in our neuroscience lab at @princetonneuro.bsky.social @hhmi.org where we study learning and decision-making circuitry.

Apply here: research-princeton.icims.com/jobs/21001/r...

Pls share w/ anyone who might be interested!
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Reposted by Armin Lak
aidanhorner.bsky.social
Aidan Horner @aidanhorner.bsky.social · Jul 21
2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department!

#neuroskyence #cognition #psychscisky #neurojobs

jobs.york.ac.uk/vacancy/lect...
Jobs - The University of York
jobs.york.ac.uk
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Reposted by Armin Lak
carandinilab.net
Matteo Carandini @carandinilab.net · Jul 18
A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.

Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...
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Reposted by Armin Lak
rberrens.bsky.social
Rebecca Berrens @rberrens.bsky.social · Jul 16
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols
Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...
doi.org
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Reposted by Armin Lak
vikaassohal.bsky.social
Vikaas Sohal @vikaassohal.bsky.social · Jun 30
New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...
Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility
While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...
www.biorxiv.org
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jul 11
More of a coach than a fan!
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jul 11
thanks for the shout-out!
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jul 4
Very nice review!
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jul 2
Really awesome results. Congratulations all
Reposted by Armin Lak
mkbholt.bsky.social
Marie K Holt @mkbholt.bsky.social · Jun 16
Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩‍🔬👨‍🔬

My department is hiring! Closing on June 30th.

Please repost widely!

www.jobs.ac.uk/job/DNK944/a...
Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 12
Thanks!
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 12
Oh thanks Tim!
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 12
Thanks
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laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 12
Thanks
laklab.bsky.social
Armin Lak @laklab.bsky.social · Jun 12
Thanks