Ryan Langlois
@langloislab.bsky.social
Professor of Microbiology and Immunology at the University of Minnesota. Interested in virus-host interactions, antiviral immunity, and virus evolution.
Apologies to @samjwilsonphd.bsky.social who had a beautiful paper on febrile temperature and avian flu replication come out after this was in press: www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
December 15, 2025 at 3:20 PM
Apologies to @samjwilsonphd.bsky.social who had a beautiful paper on febrile temperature and avian flu replication come out after this was in press: www.science.org/doi/10.1126/...
Comparative studies in species with different baseline temperatures and lifestyles could offer a window into temperature-dependent antiviral gene function. This is challenging to study as temp as a significant impact on pathogen replication.
December 15, 2025 at 3:20 PM
Comparative studies in species with different baseline temperatures and lifestyles could offer a window into temperature-dependent antiviral gene function. This is challenging to study as temp as a significant impact on pathogen replication.
I speculate that selection for antiviral gene function may occur at febrile temps yet most mechanistic studies evaluate function at basal temps. This could leave us with a blind spot in how antiviral genes function and have evolved.
December 15, 2025 at 3:20 PM
I speculate that selection for antiviral gene function may occur at febrile temps yet most mechanistic studies evaluate function at basal temps. This could leave us with a blind spot in how antiviral genes function and have evolved.
This is the exact kind of outside the box thinking we're looking for! You're double hired!
November 23, 2024 at 12:47 AM
This is the exact kind of outside the box thinking we're looking for! You're double hired!