Oh what a fabulous question. The Annabel Lee tavern in Baltimore- it was in a corner at the end of a block of row houses, with gloomy Poe themed decor. I always ordered the salad (beet and goat cheese and greens, I think) and duck fat fries.

Neal Stephenson’s “Fall: Dodge in Hell” has some interesting ideas about the possible near future of our shared information space.

Book World is the #1 reason I subscribe to the Post, and your column is always a favorite. Thanks for recommending some of my favorite reads of 2025!

The original study, and my story on it, both emphasize that the pictured molecule is a tool compound lacking important drug-like properties. Still, a cool mechanism for molecules to work by!

This is super esoteric biochemistry! But, researchers in Laura Bohn and Ed Stahl's USF labs found, you can exploit that GTP catch-and-release side reaction w/ ligands that promote it.

And in the case of opioid receptors, those ligands could do a kind of biased agonism.

cen.acs.org/biological-c...

It just seems strange to not trust drug companies and actual research and to instead trust "med spas" with iv's, people making peptides in their garages, and formulating pharmacies with the cleanliness standards of Boar's Head plants.

Classic caretaker dilemma. I try to alternate the post-bedtime self care: sleep day, run day. But there’s never enough of either.