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Reposted by Lorenzo de la Rica

Belkaid Lab @belkaidlab.bsky.social · 7d

Incredible science was shared at the #TeamPROSPECT scientific retreat this week bringing together experts in epidemiology, oncology, immunology, computational biology & more. A global effort to understand and reverse the rapid rise of early-onset colorectal cancer.
#CancerResearch #ColorectalCancer

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Reposted by Lorenzo de la Rica

Cancer Grand Challenges @cancergrand.bsky.social · 2d

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.

Read more: www.cancergrandchallenges.org/news/early-c...

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Lorenzo de la Rica @ldelarica.bsky.social · 12d

So.. who won the CGC Open?? 😂

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Science Magazine @science.org · 28d

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3

Weird rings of DNA fuel cancers. This scientist leads the effort to target them

Paul Mischel and others are testing therapies for rogue genetic loops that drive tumor evolution and growth

scim.ag

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Lorenzo de la Rica @ldelarica.bsky.social · Jun 25

We are hiring! 🚨
Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week).
Apply by: 1 July 2025
Get in touch📩
More info 👇
cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...

Research Portfolio Manager (Cancer Grand Challenges)

4,000 professionals, 0 days wasted, 1 incredible purpose. Together we are beating cancer. Research Portfolio Manager (Cancer Grand Challenges) Salary: £46,000 - £54,000 depending on experience plus be...

cancerresearchuk.wd3.myworkdayjobs.com

Lorenzo de la Rica @ldelarica.bsky.social · Jun 9

#ICYMI from team eDyNAmiC: SPACE-seq!
Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.

Julia Belk @juliabelk.bsky.social · Apr 18

Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in @pnas.org! 🧵(1/5)

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Lorenzo de la Rica @ldelarica.bsky.social · Jun 9

Last week, Regina Barzilay's group @mit.edu released Boltz-2.

With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity.

Crucially, Boltz-2 is open source.

Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).

Boltz-2: democratising the future of drug design

Open source structure prediction with binding affinity

bit.ly

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Lorenzo de la Rica @ldelarica.bsky.social · May 2

💡 ecDNA Conference
🗓️ 11–13 June 2025
📍 London, UK
🚨 Register by Monday 5th May (3 days left!!)

The full programme for our conference on ecDNA is now confirmed!

You can view all the details and register here:
www.cancergrandchallenges.org/ecDNA-2025

Reposted by Lorenzo de la Rica

Cancer Research UK @cancerresearchuk.org · May 1

🚨 New transatlantic research funding! 🚨

We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams.

Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO

Webinar: Biology to Prevention Award co-funded with American Cancer Society

Join our webinar on 21 May to learn about this new partnership and how to apply for co-funding through the Biology to Prevention Award

bit.ly

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

To keep the momentum going: check out the final programme for our #CancerGrandChallenges ecDNA conference — just released all invited and selected talk titles!. Registration closes 5 May and spots are almost gone!
🔗 www.cancergrandchallenges.org/ecDNA-2025#p...

Cancer Grand Challenges Conference: extrachromosomal DNA

Taking place on 11 - 13 June 2025 in London, UK. Registration is now open.

www.cancergrandchallenges.org

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

🌟 Hello from #AACR25 🌟

At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available.

Come by booth 2327 to learn more 💭
We're about to open!

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

Would it even be #AACR25 without the mandatory photo at their "selfie 🤳 station"???

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

Oh and @cancergrand.bsky.social even got a mention, as Nicola is part of our PROSPECT team, tackling the early onset cancers challenge, specifically Colorectal cancer #crc, led by @yincaoscd.bsky.social and Andy Chan !!

Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

The #AACR25 Discovery Sciences Plenaries, discussed interplay of somatic mutations in normal tissue (@imartincorena.bsky.social), metabolism targeting of liver cancer (Celeste Simon), epigenetic therapies (Yang Shi), and the microbiome (PROSPECT's Nicola Sagata)

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 27

Fantastic science at #AACR25 yesterday! So inspiring to see @cancergrand.bsky.social Challenges like extrachromosomal DNAs #ecDNAs 🧬⭕ (team eDyNAmiC!) and transposable elements 🦘🧬 (key for the Dark Proteome!) highlighted in the 🎓educational sessions. Really cool science being discussed 🔬!

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 25

If you want to know more about these £20m awards for bold, interdisciplinary, global teams, come by our booth (#2327) from Sunday!
Applications are open until 18 June. 🌍🔬
More info 👇
bit.ly/4iAMKgK

New challenges

Explore the challenges currently open for Expressions of Interest.

bit.ly

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 25

#AACR25 has officially started! I presented at the Professional Development Session "Grant Writing Workshop", sharing UK🇬🇧 & European🇪🇺 funding opportunities in #CancerResearch, and spotlighting our 7 #CancerGrandChallenges. @theaacr.bsky.social @cancerresearchuk.org

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Reposted by Lorenzo de la Rica

Rebecca Eccles @rebeccaeccles.bsky.social · Apr 24

The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!

Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges

features.cancerresearchuk.org/cancergrandc...

DFS 0161 CGC Discover mag 2024

A year of scientific creativity

features.cancerresearchuk.org

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 23

And the @financialtimes.com too (££)!
"Gut toxin exposure linked to rising bowel cancer cases"

www.ft.com/content/df0f...

Gut toxin exposure linked to rising bowel cancer cases

Bowel cancer is projected to become the biggest cause of cancer deaths among young adults by 2030

www.ft.com

Lorenzo de la Rica @ldelarica.bsky.social · Apr 23

@cancergrand.bsky.social funded research featured in The Guardian "Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’ "

The Guardian @theguardian.com · Apr 23

Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’

Researchers say mutations more often found in younger patients’ tumours caused by toxin secreted by E coli strains Childhood exposure to a toxin produced by bacteria in the bowel may be contributing to the rise of colorectal cancer in under-50s around the world, researchers say. Countries, including some in Europe and Oceania, have witnessed an increase in young adults with bowel cancer in recent decades, with some of the steepest increases reported in England, New Zealand, Puerto Rico and Chile. Continue reading...

www.theguardian.com

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 23

Find the full paper 📝 "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandrov @ucsdmedschool.bsky.social, here:
doi.org/10.1038/s415...

Geographic and age variations in mutational processes in colorectal cancer - Nature

Nature - Geographic and age variations in mutational processes in colorectal cancer

doi.org

Lorenzo de la Rica @ldelarica.bsky.social · Apr 23

🚨New in @nature.com
@cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases.

Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68

DFS 0161 CGC Discover mag 2024 — Early-onset cancers

A year of scientific creativity

features.cancerresearchuk.org

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Lorenzo de la Rica @ldelarica.bsky.social · Apr 15

We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇
www.cancergrandchallenges.org/ecDNA-2025

Cancer Grand Challenges Conference: extrachromosomal DNA

Taking place on 11 - 13 June 2025 in London, UK. Registration is now open.

www.cancergrandchallenges.org

Lorenzo de la Rica @ldelarica.bsky.social · Apr 15

A big congratulations to #CancerGrandChallenges Scientific Committee member, Karen Vousden for her AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research and to OPTIMISTICC co-team lead Matthew Meyerson on his AACR Award for Outstanding Achievement in Pathology in Cancer Research! 🙌👏🧬 #AACR

American Association for Cancer Research (AACR) @theaacr.bsky.social · Apr 15

Congratulations to the recipients of the 2025 AACR Scientific Achievement Awards and Lectureships. This year’s distinguished class of awardees will be recognized at #AACR25 in Chicago. www.aacr.org/about-the-aa...

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