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Lead-DBS @lead-dbs.org · Sep 3

From Adaptive DBS to Adaptive Circuit Targeting 👇👇

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

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Reposted by Lead-DBS

Stimulating Brains @stimulatingbrains.org · Sep 3

Next steps ahead for DBS! 👇👇

Andreas Horn @andreashorn.org · Sep 3

In #DeepBrainStimulation

the two major developments across the last decade have been

1. Adaptive DBS and
2. Connectomic DBS

In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:

Could the two be united into a common framework?

www.nature.com/articles/s41...

A 🧵

3 3

Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Aug 22

Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇

Lead-DBS @lead-dbs.org · Aug 22

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

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Reposted by Lead-DBS

Network Stimulation Institute @netstim.org · Aug 22

New Institute paper out 👇👇

Lead-DBS @lead-dbs.org · Aug 22

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

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Lead-DBS @lead-dbs.org · Aug 22

Unfortunately, there is no simple answer and as always, the method depends on the research question. However, these four methods have now all been included into Lead-DBS/OSS-DBS and can be conveniently analyzed on group level using the FiberFiltering Explorer (www.lead-dbs.org).

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Lead-DBS @lead-dbs.org · Aug 22

Should we use
• Electric Field Magnitude
• Electric Field projections onto fibers
• Pathway Activation Modeling
• probabilistic Pathway Activation Modeling?

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Lead-DBS @lead-dbs.org · Aug 22

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

1 5 10

Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Aug 18

Super excited for Ningfei Li to receive the highly prestigious NSFC Excellent Young Scientists Fund – as of yesterday, Ningfei is Full Professor at the Xian University and has joined a new AI institute! We are both excited to continue our collaboration on @lead-dbs.org and connectomic DBS!

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Reposted by Lead-DBS

Stimulating Brains @stimulatingbrains.org · Aug 1

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Aug 1

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?

Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

Stimulating Brains @stimulatingbrains.org · Aug 1

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Jun 24

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Lead-DBS

Lauren Hart @laurenahart.bsky.social · Jun 24

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Jun 20

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!

lnkd.in/eEbnXByJ

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · Jun 2

@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!

@braincircuits.bsky.social

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Reposted by Lead-DBS

Network Stimulation Institute @netstim.org · May 29

Hard to keep track about all the great things our labmembers have achieved recently:

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Reposted by Lead-DBS

Stimulating Brains @stimulatingbrains.org · May 29

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.

Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET

Register here: partners.zoom.us/webinar/regi...

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Reposted by Lead-DBS

Michael Okun @michaelokun.bsky.social · May 24

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

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Reposted by Lead-DBS

Isaiah Kletenik @isaiahneuro.bsky.social · May 23

Can brain injury cause the loss of visual imagination?

We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social

www.medrxiv.org/content/10.1...

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Reposted by Lead-DBS

Michael Fox @foxmdphd.bsky.social · May 24

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

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Reposted by Lead-DBS

The Science of Parkinson's @scienceofpd.bsky.social · May 23

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...

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Reposted by Lead-DBS

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · May 23

Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇

Lukas Goede @lukasgoede.bsky.social · May 22

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

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Reposted by Lead-DBS

Lukas Goede @lukasgoede.bsky.social · May 19

Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?

In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.

doi.org/10.1002/acn3...

A thread. 🧵

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...

doi.org

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Reposted by Lead-DBS

Andreas Horn @andreashorn.org · May 19

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?

@lukasgoede.bsky.social says yes – new study here:

onlinelibrary.wiley.com/doi/10.1002/...

A 🧵

@netstim.org @braincircuits.bsky.social @lead-dbs.org

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Lead-DBS @lead-dbs.org · May 14

First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇

Andreas Horn @andreashorn.org · May 14

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?

@science.org @braincircuits.bsky.social @netstim.org

– a thread🧵!

www.science.org/doi/10.1126/...

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